325 research outputs found
POLO Kinase Regulates the Drosophila Centromere Cohesion Protein MEI-S332
No full textAbstractAccurate segregation of chromosomes is critical to ensure that each daughter cell receives the full genetic complement. Maintenance of cohesion between sister chromatids, especially at centromeres, is required to segregate chromosomes precisely during mitosis and meiosis. The Drosophila protein MEI-S332, the founding member of a conserved protein family, is essential in meiosis for maintaining cohesion at centromeres until sister chromatids separate at the metaphase II/anaphase II transition. MEI-S332 localizes onto centromeres in prometaphase of mitosis or meiosis I, remaining until sister chromatids segregate. We elucidated a mechanism for controlling release of MEI-S332 from centromeres via phosphorylation by POLO kinase. We demonstrate that POLO antagonizes MEI-S332 cohesive function and that full POLO activity is needed to remove MEI-S332 from centromeres, yet this delocalization is not required for sister chromatid separation. POLO phosphorylates MEI-S332 in vitro, POLO and MEI-S332 bind each other, and mutation of POLO binding sites prevents MEI-S332 dissociation from centromeres
Correction: Tse et al. How COVID-19 Ceases All Older Adult Services & the Way Out for Community-Dwelling Older Adults with Chronic Pain. OBM Neurobiology 2023; 7: 183
No full textCorrectionCorrection: Tse et al. How COVID-19 Ceases All Older Adult Services & the Way Out for Community-Dwelling Older Adults with Chronic Pain. OBM Neurobiology 2023; 7: 183Mimi Mun Yee Tse 1, *, Shamay Sheung Mei Ng 2, Vivian Lou 3, Raymond SK Lo 4, Daphne Sze Ki Cheung 5, Paul H Lee 6, Shuk Kwan Tang 7, Siu Hang Leung 1, Percy Poo-See Tse 1* Correspondence: Mimi Mun Yee Tse; E-Mail: [email protected] Editors: Ines Testoni, Adriano Zamperini and Lorenza PalazzoSpecial Issue: How COVID-19 Changed Individual and Social Life: Psychological and Mental illness Studies on the Pandemic OutcomesOBM Neurobiology2024, volume 8, issue 1doi:10.21926/obm.neurobiol.2401213Received: March 11, 2024Accepted: March 11, 2024Published: March 12, 2024The authors wish to make the following correction to the paper [1]
sj-docx-2-tam-10.1177_17588359221087555 – Supplemental material for A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies
No full textSupplemental material, sj-docx-2-tam-10.1177_17588359221087555 for A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies by Jingshan Ho, Valerie Heong, Wei Peng Yong, Ross Soo, Cheng Ean Chee, Andrea Wong, Raghav Sundar, Yee Liang Thian, Anil Gopinathan, Mei Yan Pang, Priscillia Koe, Santhiay Nathan Jeraj, Phyu Pyar Soe, Mu Yar Soe, Tiffany Tang, Matthew C.H. Ng, David W.M. Tai, Tira J.Y. Tan, Hongmei Xu, Hua Chang, Yosef Landesman, Jatin Shah, Sharon Shacham, Soo Chin Lee, Daniel S.W. Tan, Boon Cher Goh and David S.P. Tan in Therapeutic Advances in Medical Oncology</p
sj-docx-1-tam-10.1177_17588359221087555 – Supplemental material for A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221087555 for A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies by Jingshan Ho, Valerie Heong, Wei Peng Yong, Ross Soo, Cheng Ean Chee, Andrea Wong, Raghav Sundar, Yee Liang Thian, Anil Gopinathan, Mei Yan Pang, Priscillia Koe, Santhiay Nathan Jeraj, Phyu Pyar Soe, Mu Yar Soe, Tiffany Tang, Matthew C.H. Ng, David W.M. Tai, Tira J.Y. Tan, Hongmei Xu, Hua Chang, Yosef Landesman, Jatin Shah, Sharon Shacham, Soo Chin Lee, Daniel S.W. Tan, Boon Cher Goh and David S.P. Tan in Therapeutic Advances in Medical Oncology</p
the Way Out for Community-Dwelling Older Adults with Chronic Pain
No full textThe COVID-19 pandemic started at the beginning of 2020. It significantly impacted the older adults in Hong Kong, with most of the community centers and elderly centers being closed down under various restrictive measures. Thus, community-based health promotion activities were temporarily paused, which decreased older adults’ health-promoting behaviors and motivation to stay active. This research aimed to improve the quality of life and the health of older adults with chronic pain through the pain management program. This study was conducted face-to-face on the campus of Hong Kong Metropolitan University. This dyadic pain management program (DPM) was an 8-week group-based program. The DPM comprised 4 weeks of campus-based activities and 4 weeks of digital-based activities delivered via a WhatsApp group. An 80% participation rate in the campus-based activities was regarded as completing the DPM. The control group only received lesson leaflets. Pain intensity, pain self-efficacy, psychological health of pain victims, caregiver burden inventory, and a semi-structured interview were evaluated at week 1 (T0), week 8 (T1), and week 12 (T2) after randomization. The IBM-SPSS version 22 was used to perform statistical analyses. Using non-pharmacological methods and regular exercise for 12 weeks improved physical health in terms of pain intensity, pain self-efficacy, and psychological health in anxiety, depression, and stress. For caregivers, their burden decreased after the pain management program. These findings indicated that Pender’s Health Promotion Model is helpful to empower the participants and their caregivers with knowledge, skills, and power to manage their chronic pain situations. Utilizing this model as a framework, Researchers can design more effective non-pharmacological interventions for older adults to increase their engagement in health-promoting activities in the community
Dendrimers Containing Luminescent Gold (III) Compounds for Organic Light-Emitting Devices and Their Preparation
No full textA novel class of saturated or conjugated dendrimers containing at least one strong sigma-donating group coordinated to cyclometalated tridentate gold(III) compounds having the chemical structure depicted by generic formula: wherein: (a) [Au] is a cyclometalated tridentate gold(III) group; (b) Unit A is a sigma-donating chemical group; (c) Unit B is a central part of the dendrons comprising a branch point of component dendrimers; (d) Unit C is optional surface groups or dendrons of the dendrimers; (e) n=0 or 1.published_or_final_versio
MAINTENANCE MANAGEMENT AND MARKETING OF TWO SHOPPING CENTRES IN HONG KONG
No full textBachelor'sBACHELOR OF SCIENCE (REAL ESTATE
Wind and water of two villages : investigating a possible connection between fungshui and prosperity of two villages in Ping Shan : the case of Hang Tau Tsuen and Hang Mei Tsuen
No full textAs someone who have studied Fungshui and offers Fungshui advice, I am aware that the collective success of a village is often qualified, traditionally, by the number of wealthy landlords, accomplished scholars, illustrious officials, male offspring, and long-life people. In modern times, the attribution to good Fungshui in a village is similar: by the number of rich businessmen and landowners, accomplished professionals, high-ranking government officials and high-profile celebrities. The emphasis is still on men, even though there are more clanswomen and many successful clanswomen. Based on this notion of attributing the success of clansmen to good Fungshui, I wonder if this could provide a means of measuring how “good” is good Fungshui of a village.
The Tang clan is one of the five great clans (i.e. Tang, Hau (侯), Pang (彭), Liu (廖) and Man (文)) residing in Hong Kong. Since the migration and settlement of the family to Ping Shan in the 12th Century by the 92nd generation ancestor Tang Yuen-ching (鄧元禎) with his son Tang Chung-kwong (alias Tang Man-lei) (鄧從光, 字萬里), the Tang clan of Ping Shan has been evolved for more than 800 years with a long period of economic prosperity and social achievements. Many villagers in Ping Shan attribute this success to good Fungshui in and around the villages. In what ways does Fungshui contribute to the economic and social success in villages in Ping Shan? How can this seemingly unmeasurable Fungshui qualification of success in Ping Shan be measured in more concrete terms? These are the research questions for this dissertation.
This is an investigative research into the land and the people of villages in Ping Shan, with focus on tracing notable clansmen from past to present as a measure of the reputed good Fungshui of the land.
It is with my interest in heritage and my lifelong dedication to the understanding of Fungshui that I attempt this unconventional research in making a connection between two pedagogies – the intangible cultural heritage of Fungshui and the cultural landscape of Ping Shan. The place Ping Shan, after all, is where I grew up, and this is a place to which I have strong emotional attachment. As such, I feel obligated to find out more about Ping Shan. I did not know the outcome of the research, and my expectation was that even if I did not find the connection, I would at least find out more about the history of the people and the geography of the place and contribute towards the understanding of the cultural landscape of two villages in Ping Shan.published_or_final_versionConservationMasterMaster of Science in Conservatio
Report on professional attachment with SAP Asia Pte Ltd.
No full textThe report will explain in detail of author daily involvement with the Human Resource adminstration as well as the workplace health promotion project
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