9,098 research outputs found
Near-Infrared Phosphors with Persistent Luminescence over 1000 nm for Optical Imaging
No full textPersistent phosphors with “self-sustained” light emission are considered to be one of the most promising candidates for the new-generation “background-free” optical imaging. In particular, near-infrared (NIR) persistent luminescence (PersL) over 1000 nm has demonstrated the superior power to obtain deep penetration depth and high-fidelity imaging due to the avoidance of real-time external excitation. In this chapter, we will give comprehensive insights into the state-of-the-art of NIR (>1000 nm) persistent phosphors, starting from the introduction of basic principles of light-matter interactions, followed by the description of NIR autofluorescence phenomena of bio-tissues and related filtering approaches. Then, the mechanism of PersL, including charge carrier trapping-detrapping phenomena, persistent energy transfer (ET) process, and photostimulation-induced trap redistribution approaches, will be explained to give a general picture of how PersL works and how we can play with the information of energy-level locations of host bands, activators and traps. The reported over 1000-nm NIR-persistent phosphors, basically divided into lanthanide and transition-metal ions-activated ones will be summarized with highlighted examples to introduce design concepts of these phosphors. Finally, we draw a prospective of key challenges and feasible improvements in the future following the current trends of this research field
sj-docx-1-cix-10.1177_11769351221085064 – Supplemental material for Using Natural Language Processing Techniques to Detect Adverse Events From Progress Notes Due to Chemotherapy
No full textSupplemental material, sj-docx-1-cix-10.1177_11769351221085064 for Using Natural Language Processing Techniques to Detect Adverse Events From Progress Notes Due to Chemotherapy by Yukinori Mashima, Takashi Tamura, Jun Kunikata, Shinobu Tada, Akiko Yamada, Masatoshi Tanigawa, Akiko Hayakawa, Hirokazu Tanabe and Hideto Yokoi in Cancer Informatics</p
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Bem-estar | Fabiana Tanabe e Stéfani Schneider refletem sobre novos e velhos hábitos e a retomada gradual das atividades
No full textBreves apontamentos para a retomada das atividades após o período da enchente de 2024, no Rio Grande do Sul.Em primeiro plano, lousa de quadro negro em uma calçada, onde se lê: “Bom dia! Recomeços e confortos, estamos de volta." Ao fundo e em desfoque, rua urbana, com edifícios variados e um carro preto estacionado. Fonte: Secretaria de Comunicação Social/UFRGS, 2024. Colorida.Bem-esta
author
No full textauthorIn other places [Old Joe, the trapper] pointed out otter (or, as he pronounced it, "author") slidesPRINTED ITEM G.M.Story April 1959Not UsedNot UsedWithdrawn[see 'otter']Checked by Jordyn Hughes on Thu 09 Jun 201
Cortical Blood Flow Insufficiency Scores with Computed Tomography Perfusion can Predict Outcomes in Aneurysmal Subarachnoid Hemorrhage Patients: A Cohort Study
No full text藤田医科大学博士(医学)doctoral thesi
Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang
No full textWong, Chai Kwok = 加入聚合物對均勻湍流及均勻湍流對流的影響 / 黃濟國.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 89-91).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Wong, Chai Kwok = Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang / Huang Jiguo
Author Correction: Manipulating anion intercalation enables a high-voltage aqueous dual ion battery
No full textThe original version of this Article did not acknowledge Prof. Jun Fan as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.link_to_subscribed_fulltex
Philosophie japonaise : le néant, le monde et le corps /
No full textBibliogr. p. 427-468. Glossaire. Index.Archéologie de la pensée japonaise : Dôgen, Ogyû Sorai, Motoori Noronaga -- L'appropriation créatrice de la philosophie occidentale à l'époque de Meiji : Nishi Amane, Nakae Chômin -- La systématisation philosophique de l'École de Kyoto: Nishida Kitarô, Tanabe Hajime, Tosaka Jun -- Les nouveaux visages de la philosophie japonaise : Izutsu Toshihiko, Ômori Shôzô.Van Cutsem, Lauren
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