23,534 research outputs found
Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression
No full textPaul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.Peer reviewe
Lathrobium caiyujiei Lin, Tan & Peng, 2022, new species
No full textLathrobium caiyujiei X.-B. Lin and Peng, new species (Figs 1A, 2) Type material (4 ♂♂, 2 ♀♀). Holotype ♂: “ China: Guangxi, Huanjiang, Jiuwanshan N. R., Yangmeiao, 25°12’22.15’’N, 108°40’32.01’’E, 1250 m, 23.IV.2021, Tang, Peng, Cai & Song leg.” (SNUC); Paratypes: 1 ♂, 1 ♀: same data as holotype (SNUC); 1 ♂, 1 ♀: same data, except “ 08. V.2021” (SNUC); 1 ♂: same data, except “ 25. IV.2021 ” (SNUC). Description. Measurements (in mm) and ratios: BL 8.34–9.45, FL 3.61–3.83, HL 1.24–1.39, HW 1.24–1.30, AnL 2.61–2.84, PL 1.48–1.57, PW 1.35–1.42, EL 0.83–0.87, AL 1.40–1.42, HL/HW 0.96–1.07, HW/PW 0.91–0.96, HL/PL 0.79–0.88, PL/PW 1.10–1.16, EL/PL 0.53–0.59. Habitus as in Fig. 1A. Body blackish brown, legs brown, antennae dark brown to light brown. Head punctation moderately coarse and dense, distinctly sparser in median dorsal portion; interstices with distinct microreticulation. Eyes moderately small and composed of approximately 60 ommatidia. Pronotum with weakly convex lateral margins in dorsal view; punctation somewhat sparser than that of head; impunctate midline broad; interstices glossy and without microsculpture. Elytral punctation dense and defined. Hind wings completely reduced. Protarsi without appreciable sexual dimorphism, distinctly dilated. Abdomen with fine and dense punctation, punctation of tergite VII slightly less dense than that of anterior tergites; interstices with shallow microsculpture; posterior margin of tergite VII without palisade fringe; tergite VIII with weakly pronounced sexual dimorphism. Male. Sternites III–VI unmodified; sternite VII (Fig. 2D) with posterior margin shallowly concave in the middle, setae unmodified; posterior margin of sternite VIII (Fig. 2E) strongly convex and with moderately dense micropubescence, with sparse and short setae; aedeagus as in Figs 2F, G, with stout ventral process of highly distinctive shape; dorsal plate with long apical portion, and with very short basal portion; internal sac without sclerotized spines. Female. Posterior margin of tergite VIII (Fig. 2A) strongly convex. Posterior margin of sternite VIII (Fig. 2B) strongly convex and with moderately dense micropubescence; tergite IX (Fig. 2C) with short antero-median portion and slender postero-lateral processes; tergite X (Fig. 2C) 2.5 times as long as antero-median portion of tergite IX. Comparative notes. Based on the morphology of the aedeagus, this species may be allied to L. zhujianqingi Peng & Li, 2012, from which it is distinguished by somewhat smaller body size, lighter coloration of the body, the chaetotaxy of the male sternite VII, and a more slender aedeagus. For illustrations of L. zhujianqingi see Peng et al. (2012: figures 1F, 7). Etymology. The species is named after Yu-Jie Cai, who collected some of type specimens. Distribution and natural history. The type locality is situated in the Jiuwanshan Nature Reserve to the north of Huanjiang, northern Guangxi. The specimens were sifted from leaf litter and grass roots in shrub habitats at an altitude of 1250 m.Published as part of Lin, Xiao-Bin, Tan, Fei & Peng, Zhong, 2022, New data on the genus Lathrobium Gravenhorst (Coleoptera: Staphylinidae: Paederinae) of Guangxi, South China, pp. 593-600 in Zootaxa 5099 (5) on pages 594-596, DOI: 10.11646/zootaxa.5099.5.6, http://zenodo.org/record/611065
Lathrobium zhusha Lin, Tan & Peng, 2022, new species
No full textLathrobium zhusha X.-B. Lin and Peng, new species (Figs 1C, 4) Type material (1 ♂). Holotype ♂: “ China: Guangxi, Huanjiang, Jiuwanshan N. R., Yangmeiao, 25°12’22.15’’N, 108°40’32.01’’E, 1250 m, 25.IV.2021, Tang, Peng, Cai & Song leg.” (SNUC). Description. Measurements (in mm) and ratios: BL 7.51, FL 2.96, HL 0.96, HW 0.91, AnL 2.08, PL 1.32, PW 1.03, EL 0.68, AL 1.26, HL/HW 1.05, HW/PW 0.88, HL/PL 0.72, PL/PW 1.28, EL/PL 0.52. Habitus as in Fig. 2C. Body reddish brown, legs yellowish brown, antennae reddish brown to yellowish brown. Head punctation moderately fine and sparse, somewhat sparser in median dorsal portion; interstices with shallow microsculpture. Eyes small and composed of approximately 40 ommatidia. Pronotum nearly parallel-sided; punctation similar to that of head; impunctate midline broad; interstices glossy and without microsculpture. Elytral punctation moderately sparse and shallow. Hind wings completely reduced. Protarsomeres I–IV with weak sexual dimorphism. Abdomen with fine and dense punctation, punctation of tergite VII slightly less dense than that of anterior tergites; interstices with shallow microsculpture; posterior margin of tergite VII without palisade fringe; tergite VIII with weakly pronounced sexual dimorphism. Male. Sternite VII (Fig. 4A) with apical margin broadly concave, setae unmodified; sternite VIII (Fig. 4B) with V–shaped posterior excision, with numerous distinctly modified; aedeagus as in Figs 4C, D; ventral process weakly hooked apically in lateral view; dorsal plate with long apical portion and very short basal portion; internal sac with one sclerotized spine. Female. Unknown. Comparative notes. Based on the morphology of the aedeagus, this species may be allied to L. hujiayaoi, from which it is distinguished by somewhat smaller body size, the lighter coloration of the body, the chaetotaxy of the male sternite VIII and the nearly straight ventral process of the aedeagus. Lathrobium zhusha is distinguished from the syntopic L. jinxiuense by smaller body size, reddish coloration of the body, the broadly V–shaped posterior excision of the male sternite VIII, by the shape of ventral process and dorsal plate of the aedeagus, as well as the shape of the female tergite VIII. For illustrations of L. hujiayaoi see Peng et al. (2013: figures 2B, 4C–G). For illustrations of L. jinxiuense see Peng et al. (2015: figures 4A, 5). Etymology. The specific name is the Chinese noun “zhusha” (cinnabar) in apposition. It refers to the characteristic color of the body in comparison to the other species known from the Jiuwanshan Nature Reserve. Distribution and natural history. The type locality is situated in the Jiuwanshan Nature Reserve to the north of Huanjiang, northern Guangxi. The specimens were sifted from leaf litter and grass roots in shrub habitats at an altitude of 1250 m.Published as part of Lin, Xiao-Bin, Tan, Fei & Peng, Zhong, 2022, New data on the genus Lathrobium Gravenhorst (Coleoptera: Staphylinidae: Paederinae) of Guangxi, South China, pp. 593-600 in Zootaxa 5099 (5) on pages 599-600, DOI: 10.11646/zootaxa.5099.5.6, http://zenodo.org/record/611065
Lathrobium jiuwanshanense Lin, Tan & Peng, 2022, new species
No full textLathrobium jiuwanshanense X.-B. Lin and Peng, new species (Figs 1B, 3) Type material (2♂♂, 1♀). Holotype ♂:“ China: Guangxi,Huanjiang, Jiuwanshan N. R.,Yangmeiao, 25°12’22.15’’N, 108°40’32.01’’E, 1250 m, 25.IV.2021, Tang, Peng, Cai & Song leg.” (SNUC); Paratypes: 1 ♀: same data as holotype (SNUC); 1 ♂: “ China: Guangxi, Liuzhou City, Jiuwanshan N. R., Yangmei’ao, 25°11’42’’N, 108°38’51’’E, mixed leaf litter, sifted, 1200 m, 24–26.VII.2015, Li & Zhao leg.” (SNUC). Description. Measurements (in mm) and ratios: BL 6.67–7.62, FL 2.86–3.37, HL 0.99–1.22, HW 0.99–1.14, AnL 1.99–2.20, PL 1.24–1.40, PW 1.06–1.26, EL 0.61–0.76, AL 1.46–1.50, HL/HW 1.00–1.07, HW/PW 0.90–0.93, HL/PL 0.78–0.87, PL/PW 1.11–1.19, EL/PL 0.48–0.54. Habitus as in Fig. 1B. Body blackish brown, legs reddish brown, antennae dark brown to light brown. Head punctation coarse and moderately sparse, distinctly sparser in median dorsal portion; interstices with distinct microreticulation. Eyes moderately small and composed of approximately 60 ommatidia. Pronotum with weakly convex lateral margins in dorsal view; punctation similar to that of head; impunctate midline broad; interstices glossy and without microsculpture. Elytral punctation moderately dense and shallow. Hind wings completely reduced. Protarsomeres I–IV with weak sexual dimorphism. Abdomen with fine and dense punctation, punctation of tergite VII slightly less dense than that of anterior tergites; interstices with shallow microsculpture; posterior margin of tergite VII without palisade fringe; tergite VIII with weakly pronounced sexual dimorphism. Male. Sternite VII (Fig. 3D) with posterior margin truncate at middle, with modified black setae; sternite VIII (Fig. 3E) with wide triangular posterior excision; aedeagus as in Figs 3F, G, with stout ventral process of highly distinctive shape, hooked apically in lateral view; internal sac with one sclerotized spine. Female. Posterior margin of tergite VIII (Fig. 3A) strongly convex. Posterior margin of sternite VIII (Fig. 3B) strongly convex and with moderately dense micropubescence; tergite IX (Fig. 3C) with short antero-median portion and slender postero-lateral processes; tergite X (Fig. 3C) 2.5 times as long as antero-median portion of tergite IX. Comparative notes. The new species resembles L. maoershanense Peng & Li, 2012 in habitus and the similarly derived morphology of sternites VII–VIII, but differs from this species by the stouter ventral process and the simple internal sac of the aedeagus. For illustrations of L. maoershanense see Peng et al. (2012: figures 1B, 3). Etymology. The species is named for its type locality (Jiuwanshan Nature Reserve). Distribution and natural history. Two type localities are situated in the Jiuwanshan Nature Reserve to the north of Huanjiang, northern Guangxi. The specimens were sifted from leaf litter and grass roots in shrub habitats at an altitude of 1200–1250 m.Published as part of Lin, Xiao-Bin, Tan, Fei & Peng, Zhong, 2022, New data on the genus Lathrobium Gravenhorst (Coleoptera: Staphylinidae: Paederinae) of Guangxi, South China, pp. 593-600 in Zootaxa 5099 (5) on pages 596-597, DOI: 10.11646/zootaxa.5099.5.6, http://zenodo.org/record/611065
Lathrobium dayaoshanense Peng & Li 2012
No full textLathrobium dayaoshanense Peng and L.-Z. Li, 2012 Material studied. CHINA: Guangxi: 1 ♀, Guilin City, Huaping N. R., Yunxi Valley, 25°34’00.62’’N, 109°56’19.59’’E, 1460–1550 m, 23.IV.2021, sifting, Yin, Zhang, Pan & Shen leg. (SNUC). Comment. The distribution is confined to several localities in the Dayao Shan range in central Guangxi.Published as part of Lin, Xiao-Bin, Tan, Fei & Peng, Zhong, 2022, New data on the genus Lathrobium Gravenhorst (Coleoptera: Staphylinidae: Paederinae) of Guangxi, South China, pp. 593-600 in Zootaxa 5099 (5) on page 596, DOI: 10.11646/zootaxa.5099.5.6, http://zenodo.org/record/611065
Neogastromyzon brunei Tan 2006
No full textNeogastromyzon brunei Tan, 2006 BE (BR) Neogastromyzon nieuwenhuisii (non-Popta): Choy & Chin, 1994: 763 (Belalong-Temburong basin upstream of Kuala Belalong). Neogastromyzon nieuwenhuisi (non-Popta): Kottelat & Lim, 1995: 236 (Brunei). Neogastromyzon brunei Tan, 2006: 194, fig. 126-127 (Temburong basin: Sungai Enkabang, tributary of Sungai Belalong).Published as part of Sulaiman, Zohrah, Hui, Tan Heok & Lim, Kelvin Kok Peng, 2018, Annotated checklist of freshwater fishes from Brunei Darussalam, Borneo in Zootaxa 4379 (1), DOI: 10.11646/zootaxa.4379.1.2, http://zenodo.org/record/117231
Lathrobium hujiayaoi Peng & Li 2013
No full textLathrobium hujiayaoi Peng and L.-Z. Li, 2013 Material studied. CHINA: Guangxi: 1 ♂, Xing’an County, Maoer Mt., 25°54’05.08’’N, 110°28’13.51’’E, 1360 m, 07. V.2021, Yin, Zhang, Pan & Shen leg. (SNUC); Hunan: 1 ♂, Xinning County, Shunhuang Peak, 26°22’01.58’’N, 111°00’27.74’’E, 1710–1870 m, 01. V.2021, sifting, Yin, Zhang, Pan & Shen leg. (SNUC). Comment. The above record from Hunan represents a new province record.Published as part of Lin, Xiao-Bin, Tan, Fei & Peng, Zhong, 2022, New data on the genus Lathrobium Gravenhorst (Coleoptera: Staphylinidae: Paederinae) of Guangxi, South China, pp. 593-600 in Zootaxa 5099 (5) on page 596, DOI: 10.11646/zootaxa.5099.5.6, http://zenodo.org/record/611065
Lathrobium maoershanense Peng & Li 2012
No full textLathrobium maoershanense Peng and L.-Z. Li, 2012 Material studied. CHINA: Guangxi: 5 ♂♂, 5 ♀♀, Xing’an County, Maoer Shan, 25°51’57.56’’N, 110°24’46.19’’E, 2100 m, 05. V.2021, bamboo, broad-leaved bush, sifting, Yin, Zhang, Pan & Shen leg. (SNUC); 2 ♂♂, 5 ♀♀, same data, but Lijiangyuan, 25°53’32.64’’N, 110°25’41.68’’E, 1990–2030 m, 06. V.2021, sifting, Yin, Zhang, Pan & Shen leg. (SNUC); Hunan: 2 ♂♂, 1 ♀, Xinning County, Shunhuang Shan, 26°22’01.58’’N, 111°00’27.74’’E, 1710–1870 m, 01. V.2021, sifting, Yin, Zhang, Pan & Shen leg. (SNUC). Comment. The above record from Hunan represents a new province record.Published as part of Lin, Xiao-Bin, Tan, Fei & Peng, Zhong, 2022, New data on the genus Lathrobium Gravenhorst (Coleoptera: Staphylinidae: Paederinae) of Guangxi, South China, pp. 593-600 in Zootaxa 5099 (5) on page 597, DOI: 10.11646/zootaxa.5099.5.6, http://zenodo.org/record/611065
Lobocheilos ovalis Kottelat & Tan 2008
No full textLobocheilos ovalis Kottelat & Tan, 2008 BE Lobocheilos bo (non-Popta): Choy & Chin, 1994: 765 (Belalong-Temburong basin upstream of Kuala Belalong); Kottelat & Lim, 1995: 230 (Brunei). Lobocheilos ovalis Kottelat & Tan, 2008: 42, fig. 10 (Temburong district: Sungai Temburong and Belalong subbasin).Published as part of Sulaiman, Zohrah, Hui, Tan Heok & Lim, Kelvin Kok Peng, 2018, Annotated checklist of freshwater fishes from Brunei Darussalam, Borneo in Zootaxa 4379 (1), DOI: 10.11646/zootaxa.4379.1.2, http://zenodo.org/record/117231
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