22,403 research outputs found
Jun Tan interview for the China Boom Project
No full textJun Tan, a migrant worker who works at a manufacturing factory, was interviewed by the Asia Society staff in Chengdu, China in March 2009.Transcript and interviewee's bio are available.Original video interviews are available at the Asia Society.The China Boom Project classified this interviewee’s field as Vox Populi
sj-docx-1-tan-10.1177_17562864231165561 – Supplemental material for The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson’s disease
No full textSupplemental material, sj-docx-1-tan-10.1177_17562864231165561 for The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson’s disease by Ning-Ning Che, Qiu-Huan Jiang, Shuai Chen, Si-Yuan Chen, Zhen-Xiang Zhao, Xue Li, Jian-Jun Ma, Jie-Wen Zhang, Rayaz A. Malik and Hong-Qi Yang in Therapeutic Advances in Neurological Disorders</p
sj-docx-1-tan-10.1177_17562864211070449 – Supplemental material for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis
No full textSupplemental material, sj-docx-1-tan-10.1177_17562864211070449 for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis by Jennifer S. Graves, Marius Thomas, Jun Li, Anuja R. Shah, Alexandra Goodyear, Markus R. Lange, Heinz Schmidli, Dieter A. Häring, Tim Friede and Jutta Gärtner in Therapeutic Advances in Neurological Disorders</p
sj-docx-2-tan-10.1177_17562864211070449 – Supplemental material for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis
No full textSupplemental material, sj-docx-2-tan-10.1177_17562864211070449 for Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis by Jennifer S. Graves, Marius Thomas, Jun Li, Anuja R. Shah, Alexandra Goodyear, Markus R. Lange, Heinz Schmidli, Dieter A. Häring, Tim Friede and Jutta Gärtner in Therapeutic Advances in Neurological Disorders</p
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
Full text linkG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
sj-docx-1-tan-10.1177_17562864231218181 – Supplemental material for Effect of altered gene expression in lipid metabolism on cognitive improvement in patients with Alzheimer’s dementia following fecal microbiota transplantation: a preliminary study
No full textSupplemental material, sj-docx-1-tan-10.1177_17562864231218181 for Effect of altered gene expression in lipid metabolism on cognitive improvement in patients with Alzheimer’s dementia following fecal microbiota transplantation: a preliminary study by Jun-Seob Kim, Hyelim Park, Jung-Hwan Lee, Jongbeom Shin, Boram Cha, Kye Sook Kwon, Yong Woon Shin, Yerim Kim, YeoJin Kim, Jong Seok Bae, Ju-Hun Lee, Seok-Jin Choi, Tae Jung Kim, Sang-Bae Ko and Soo-Hyun Park in Therapeutic Advances in Neurological Disorders</p
Report on industrial orientation with CPG Consultants Pte Ltd
No full textCPG Consultants Pte Ltd (CPG Consultants) is a subsidiary of CPG Corp that provides consultancy services. In its Mechanical & Electrical (M&E) Division, CPG Consultants offers comprehensive design of M&E Engineering systems that are intelligent, energy-efficient, environmentally friendly and sustainable. With areas of focus on Air-Conditioning and Mechanical Ventilation, Fire Protection System and Plumbing and Sanitary during his internship, Jun Khiang sought to understand the industry better and the design constraints of building services with reference to the Green Mark requirements. He was also tasked with assisting a senior engineer and the Mechanical team in several major and minor projects
A wireless power transfer system for electrical vehicles exploiting magnetically coupled resonance and a tapped capacitance impedance transformer
Full text linkThe input impedance of a wireless power transfer system is heavily influenced by variation of the load impedance, distance between coils and presence of any massive conducting or shielding structures that may exist around the system. To achieve the maximum efficiency for the wireless link transfer one has to ensure good matching between the power source and the wireless power transfer (WPT) system for different working conditions. In this paper an equivalent circuit of the WPT which accounts for the effects of the proximity of massive conducting structures is developed. A novel tapped capacitance impedance transformer for dynamic matching purposes is introduced and its presence incorporated into the equivalent circuit; its effect on the efficiency of the system is investigated
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