52 research outputs found
Patient selection for proton therapy in head and neck cancer
Get PDFThis thesis has thoroughly investigated the criteria used in Europe to select patients for proton therapy. Head and neck cancer was found to be the second most commonly treated tumor type after tumors in the central nervous system, accounting for 15% of all adult patients receiving proton therapy in Europe in 2020. It has shown that model-based selection of head and neck cancer patients for proton therapy is clinically feasible. It describes developed preselection and decision support tools to identify patients who may benefit most from proton therapy. In addition, an extensive systematic review of the models that can be used to estimate the risk of radiation-induced complications after radiotherapy in head and neck cancer patients was performed
Human Papillomavirus in Head and Neck Cancer
No full textThroughout the last three decades, there has been a notable shift in the epidemiology of head and neck cancer (HNC) worldwide. A rapidly spreading subtype of HNCs is caused by human papillomavirus (HPV) infection. HPV-related cancers are now considered to constitute 30-65% of all HNC cases and 50-80% of oropharyngeal cancers. HPV-positive oropharyngeal cancers have a unique demographic profile and tumor biology characteristics. HPV-associated patients predominantly consist of younger men with better performance status and fewer comorbid diseases. They have better dentition, higher numbers of oral sex partners, and use less amount of tobacco or alcohol, higher amount of marijuana compared with HPV-negative patients. In addition, patients with HPV-positive tumors have a 60-80% reduced mortality rates, a finding that was confirmed by multiple trials and led to several ongoing deintensification studies. This chapter describes epidemiologic features of HPV-positive HNC, risk factors for HPV infection and HPV-associated oropharyngeal cancer, HPV detection methods, mechanisms of carcinogenesis and improved treatment response, and the impact of HPV status on clinical outcome as well as deintensification approaches and potential of vaccination
The efficacy of Pistacia Terebinthus soap in the treatment of cetuximab-induced skin toxicity
No full textThis open-labeled phase II, efficacy-finding study evaluated the efficiency and safety of Pistacia terebinthus soap in metastatic colorectal cancer patients who developed cetuximab induced skin toxicity. Patients who received cetuximab plus chemotherapy and developed Grade 2 or 3 skin toxicity were treated twice daily with a soap made of oil extracted from Pistacia terebinthus. During treatment, no topical or oral antibiotics, corticosteroids or other moisturizers were used. Patients were examined 1 week later and their photographs were taken. Fifteen mCRC patients who developed skin toxicity while receiving first-line CTX in combination with chemotherapy were included into the study. Eight patients were male and the median age was 58 (25-70). Sixty percent of the patients (n:9) had Grade 3 skin toxicity. Complete response rates in patients with Grade 2 and Grade 3 skin toxicities were 100 and 33 %, respectively. In the remaining patients with Grade 3 toxicity the skin toxicity regressed to Grade 1. The objective response rate was 100 %, and no delay, dose reduction or discontinuation of CTX treatment due to skin toxicity was necessary. Skin toxicity reoccurred in all patients when patients stopped administering the soap and therefore they used it throughout the cetuximab treatment. Pistacia terebinthus soap seemed to be used safely and effectively in the treatment of skin toxicity induced by Cetuximab
Bursa as the place of literature, love and memory in Kemal Selçuk’s novel Named Cemiyet Kaçkını
No full textBursa Mustafakemalpaşa doğumlu yazar Kemal Selçuk (1971), Cemiyet Kaçkını (2016) adlı romanında; edebiyat, yazı, aşk meselelerine eğilirken arka planda daimî bir Bursa silüeti okura eşlik eder. Kendisine kurduğu aşk üçgeni (Kerim, Makbule, Oğuz) içinde devinen öykücü Oğuz Bayrak’ın bunalımlarına sahne olan Bursa, 1980’lerden 2000’lere uzanan bir değişimin de öznesi konumundadır. Romanda, Oğuz ile Kerim arasındaki rekabet ve edebiyat tutkusunun şahidi; sahaflar, dergi çıkarma, imza günleri vb. etkinlikler, şehrin edebî damarını işaret ederken ikilinin gönül verdiği Makbule ise amatör edebiyat sevgisi kadar Bursa’ya derinden bağlılığıyla da âdeta şehrin belleği rolündedir. Cemiyet Kaçkını, salt Oğuz’un Makbule’ye olan imkânsız aşkını anlatan bir roman değil, aynı zamanda, bellek mekânı olarak Bursa’nın mazisine ve hâldeki değişimine de ışık tutan modern bir kent anlatısıdır. Bu çalışmada; Kemal Selçuk’un, aynı kadına âşık iki edebiyatsever yazar adayının serüvenlerini anlattığı Cemiyet Kaçkını adlı romanına mekân olarak seçtiği kadim kent Bursa’nın; edebiyata, aşka ve şehrin belleğine uzanan hikâyesi üzerinde durulacaktır.Born in Bursa’s Mustafakemalpaşa in 1971, author Kemal Selçuk delves into literature, writing, and matters of love in his novel Cemiyet Kaçkını (2016), with the ever-present silhouette of Bursa accompanying the reader in the background. The city becomes a stage for the turmoil of the storyteller Oğuz Bayrak, who navigates a love triangle he has constructed for himself (Kerim, Makbule, Oğuz), spanning from the 1980s to the 2000s. The competition and literary passion between Oğuz and Kerim are witnessed by antiquarian bookstores, magazine publications, signing events, and similar activities, which highlight the literary vein of the city. Meanwhile, Makbule, the woman both are enamored with, embodies the memory of the city with her profound attachment to Bursa and her amateur love for literature. Consequently, Cemiyet Kaçkını is not merely a novel about Oğuz’s unrequited love for Makbule but also a modern urban narrative that sheds light on Bursa’s past and ongoing transformation as a memory space. This study will focus on the story of the ancient city of Bursa, chosen by Kemal Selçuk as the setting for his novel Cemiyet Kaçkını, which tells the adventures of two literature-loving aspiring writers in love with the same woman, extending to literature, love, and the city’s memory
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