7 research outputs found
Two-year follow-up of a thyroid cartilage metastasis from prostate cancer: A case report
No full textFew case reports describe metastatic prostate cancer to the thyroid cartilage. While earlier reports identified the metastatic lesions upon developing symptoms, more recent ones have detected them via prostate-specific membrane antigen positron emission tomography (PSMA PET). Herein, we report the case of a patient with metastatic castrate-resistant prostate cancer and a PSMA PET-detected lesion in the thyroid cartilage. Over the course of 2 years, he received multiple lines of chemotherapy and hormonal therapy, and his overall disease status fluctuated — some nodal and bony metastases resolved while others appeared anew. His thyroid cartilage lesion, however, slowly progressed in a consistent fashion with increasing uptake on successive PSMA PET images. Apart from mild dysphonia, the patient remained to be asymptomatic from this lesion, and no local therapies were used. To our knowledge, this is the first close follow-up of prostate cancer metastatic to the thyroid cartilage, shedding light on the course of such lesions and helping answer management-related questions, which are particularly relevant as more occult metastases are discovered in the PSMA PET era
A Review on the Evolving Role of Radiation Therapy in the Treatment of Locally Advanced Rectal Cancer
No full textTreatment of locally advanced rectal cancer (LARC), clinical stages II–III, typically involves multimodal treatment options. Over the past decade, the role of radiation therapy as a neoadjuvant treatment for LARC has evolved and is currently a part of total neoadjuvant therapy (TNT). Some recently published studies advocate for the omission of radiation therapy entirely, while others report on a non-operative approach that emphasizes the use of higher radiation therapy doses. This review aims to evaluate the latest literature on the current role of radiation therapy in the management of LARC, with a discussion of how to best select the most appropriate treatment protocol based on individual patient and tumor characteristics, comorbidities, and personal needs and preferences
Neglected Tropical Diseases in Lebanon
No full textIntroduction: Neglected tropical diseases (NTDs) are highly endemic and distributed within the Middle East and North Africa (MENA) region, affecting an estimated 65 million people. Lebanon suffers from several NTDs as they are either endemic in the country or imported via expats residing in endemic regions, refugees, and foreign labor force. The Syrian crisis and the displacement of refugees to Lebanon have made the country the largest host of refugees per capita right after the Syrian crisis in 2011, peaking in the year of 2013. Additionally, foreign labor in Lebanon come from different countries in Africa and Asia that are endemic with certain NTDs. The Lebanese diaspora is approximately twice the number of those residing in the country and is distributed throughout the continents carrying the risk of importing new NTDs. Materials and Methods: A descriptive study about the prevalence of NTDs in Lebanon, their distribution, and factors contributing to spread was performed. The Lebanese Ministry of Public Health (LMPH) database regarding reportable transmissible diseases was reviewed for reportable NTDs between 2002 and 2020 in relation to age, gender, prevalence, and geographical distribution. The medical literature was searched using several engines looking for all reports about NTDs in Lebanon, those relevant to regions hosting Lebanese diaspora, and countries where the refugees and migrant workers came from. Results: Only leishmaniasis, leprosy, echinococcosis, schistosomiasis, and rabies are mandatorily reportable NTDs by the LMPH. Additionally, case reports about fasciolosis, ascaridiosis, and Dengue were reported from Lebanon. The presence of the Syrian refugees in the country affected the prevalence of leishmaniasis and rabies. The most prevalent NTD in Lebanon is cutaneous leishmaniasis. The Lebanese diaspora reside mainly in South America, Africa, and in some Arab states known to be endemic with certain NTDs. Conclusion: Little information is known about NTDs in Lebanon. The country is at an increased risk of experiencing several new NTDs due to refugee influx, foreign labor, economic crisis, and ever-growing number of Lebanese seeking work opportunities abroad. More information is needed to assess the true burden of NTDs in Lebanon and the future steps to contain and mitigate their effects. © 2022, The Author(s) under exclusive licence to Witold Stefański Institute of Parasitology, Polish Academy of Sciences
Monosaccharide Constituents of Potato Root Exudate Influence Hatching of the White Potato Cyst Nematode
No full textPlants secrete a large array of compounds into the rhizosphere to facilitate interactions with their biotic environment. Some of these exuded compounds stimulate the hatching of obligate plant-parasitic nematodes, ultimately leading to a detrimental effect on the host plant. Determining these cues can help to provide new mechanisms for control and aid nematode management schemes. Here, we show that glucose, fructose, and arabinose, which are all present in potato root exudate (PRE), induce hatching of white potato cyst nematode (Globodera pallida) eggs whereas five other PRE sugars had no effect. Although these monosaccharides resulted in significant hatching, none induced the same level as PRE, suggesting that other components, possibly in combination, contribute to stimulation of nematode hatching. Glucose but not arabinose or fructose was also observed to attract juvenile G. pallida, indicating that these hatch-inducing components can have different roles in different stages of the life cycle. Applying a solution of these monosaccharides to G. pallida-infested soil prepotato planting initiated hatching in the absence of a host. Host absence resulted in nematode mortality and a reduction in the G. pallida population. Therefore, subsequent invasion of the crop postplanting was also reduced compared with untreated soil. Our data suggest that monosaccharide components of PRE play an important role in the hatching and attraction of G. pallida. As a result, the hatch-inducing monosaccharides can be applied as a preplanting treatment to induce hatching and reduce subsequent infection rates.[Figure: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license
Bladder Cancer Treatments in the Age of Personalized Medicine: A Comprehensive Review of Potential Radiosensitivity Biomarkers
No full textBladder cancer is one of the most frequently diagnosed cancers in men. While cystectomy remains the primary treatment, advances in radiotherapy and chemotherapy have highlighted the value of bladder-preserving strategies, which can also enhance patients’ quality of life. Despise these advances, around 20% of patients may still require salvage cystectomy due to tumor radioresistance. This underscores the need to develop radiosensitivity predictive assays. Radiotherapy acts by inducing DNA damage, primarily through DNA double-strand breaks, which can significantly affect treatment outcomes if left unrepaired. In addition to activating DNA repair pathways, the response to radiation also involves the tumor microenvironment, cell death pathways, immune responses and different types of cell death and proliferation receptors. In recent years, personalized medicine, which tailors treatments to individual patients, has gained increasing attention in cancer care. The development of chemo- and radiosensitivity predictive assays has become a key focus of cancer research. Despite the potential impact of such assays on bladder cancer treatment, there is still no reliable test that can help clinicians and informs patients in choosing the best treatment. This review aims to highlight studies that attempted to characterize bladder cancer radiosensitivity and to discuss the potential biomarkers that could be used to develop bladder cancer radiosensitivity predictive assays
New and renewable energy and environmental engineering
No full textThere is an acute scarcity of potable water in many parts of the world, and especially in most of the Middle East region. Important advances have been made in desalination technology but its wide application is restricted by relatively high capital and input energy costs, even when solar energy is used. Until recently, flat-plate solar collectors have usually been employed to distill water in compact desalination systems. Currently, it is possible to replace these collectors by the more advanced evacuated tube collectors, which are now available on the market at a similar price. The research which is concerned with the development of a novel small scale solar water desalination technology, consists of experimental and theoretical investigations of the operation of a multi stage solar still desalination system coupled with a heat pipe evacuated tube solar collector with an aperture area of about 1.7 m(^2). The multi stage still was tested to recover latent heat from the evaporation and condensation processes in each of its four stages. A number of experimental tests were carried out using a laboratory rig to investigate its water production capacity. Solar radiation (insolation) during a mid-summer day in the Middle East region was simulated by an array of 110 halogen flood lights. Computational Fluid Dynamics (CFD) modeling of the evaporation and condensation processes in one of the still's stages was conducted using FLUENT 6.2 software. The simulation results demonstrate the importance of the various parameters affecting the total production rate of the solar still and provide detailed information on the temperature distribution and condensate formation inside the solar still. However, it was found that the CFD technique at this stage does not provide accurate quantitative predictions and results obtained can be used only for qualitative analysis. Hence, the use of a lumped parameter mathematical model was preferred for analysis and design purpose. A lumped parameter model has been developed to describe the system's operation. It consists of a system of ordinary differential equations of energy and mass conservation written for each stage of the still. A MATLAB computer program was written to solve the system of governing equations to simulate the evaporation and condensation processes and the experimental results were used to validate numerical predictions. The experimental and theoretical values for the total daily distillate output were found to be closely correlated. The test results demonstrate that the system produces about 9 kg of clean water per day and has a distillation efficiency of 90%. The overall efficiency is 33% due to the presence of heat losses in the system. However, this level of efficiency is greater of that for conventional solar stills. Following the experimental calibration of the lumped parameter model, this was used for determination of rational design parameters of the still and it was demonstrated that the performance of the system could be considerably improved to produce 11 kg/m(^2) of water per day if the number of stages and evaporation area were 4 and 1 m(^2), respectively. A water quality analysis was performed for the distilled water and the levels of total dissolved solids, electrical conductivity and pH were well within the range defined by the World Health Organization guidelines for drinking water. An economic study was also conducted for the system and it was shown that the distilled water costs of 0.016 US$/litre with a payback period of 6 months in the Middle East region conditions. This research demonstrates, empirically and theoretically, the potential role in the field of solar desalination of the multistage solar still coupled to the evacuated tube solar collector. Not only is this system a promising new technology but it could prove to be particularly appropriate in remote and rural areas. Simultaneously this system also uses a completely clean energy source and contributes to tackling environmental pollution, global carbon emissions and climate change problems
Health-related articles on Syria before and after the start of armed conflict: a scoping review for The Lancet-American University of Beirut Commission on Syria
No full textIntroduction
Armed conflict may influence the size and scope of research in Arab countries. We aimed to assess the impact of the 2011 Syrian conflict on health articles about Syria published in indexed journals.
Methods
We conducted a scoping review on Syrian health-related articles using seven electronic databases. We included clinical, biomedical, public health, or health system topics published between 1991 and 2017. We excluded animal studies and studies conducted on Syrian refugees. We used descriptive and social network analyses to assess the differences in rates, types, topics of articles, and authorship before and after 2011, the start of the Syrian conflict.
Results
Of 1138 articles, 826 (72.6%) were published after 2011. Articles published after 2011 were less likely to be primary research; had a greater proportion reporting on mental health (4.6% vs. 10.0%), accidents and injuries (2.3% vs. 18.8%), and conflict and health (1.7% vs. 7.8%) (all p < 0.05); and a lower proportion reporting on child and maternal health (8.1 to 3.6%, p = 0.019). The proportion of research articles reporting no funding increased from 1.1 to 14.6% (p < 0.01). While international collaborations increased over time, the number of articles with no authors affiliated to Syrian institutions overtook those with at least one author affiliation to a Syrian institution for the first time in 2015.
Conclusion
To our knowledge, this is the first study to examine the impact of armed conflict on health scholarship in Syria. The Syrian conflict was associated with a change in the rates, types, and topics of the health-related articles, and authors’ affiliations. Our findings have implications for the prioritization of research funding, development of inclusive research collaborations, and promoting the ethics of conducting research in complex humanitarian settings
