4,150 research outputs found
ko-ax photo [Selected by Tate Curator of Photography, Simon Baker]
No full textko-ax photo was an open submission competition selected by Simon Baker (Curator of Photography, Tate), Sue Steward (Photography critic, Telegraph, Observer, Guardian, BBC) and John Gill (Curator Brighton Photo Biennial and Founder Photoworks). The 10 artists selected all presented fascinating artworks that conceal narratives and ask questions of the viewer. Questions of beauty, family, decay and fantasy were all explored across over 50 works.</p
The people behind the papers – Jason Ko and Daniel Lobo
No full textPlanarians grow when they are fed and shrink during periods of starvation. However, it is unclear how they maintain appropriate body proportions as their size changes. A new paper in Development investigates the differences between growth and shrinkage dynamics and builds a mathematical model to explore the mechanisms underpinning these two processes. To learn more about the story behind the paper, we caught up with first author, Jason Ko, and corresponding author, Daniel Lobo, Associate Professor at the University of Maryland.https://doi.org/10.1242/dev.20298
Organizational Learning and Marketing Capability Development: A Study of Charity Retailing Operation of British Social Enterprises
No full textSocial enterprise is a hybrid form of profit- and social benefit-seeking organization whereby traditional nonprofit organizations pursue both their social mission and business opportunities. To embrace this new strategic direction shift, the nonprofit organizations need to develop new competences that will enable them to respond to the changes in the business model. The article investigates the learning mechanisms through which social enterprises develop a marketing capability to deploy their resources in the marketplace as the drivers of competitive advantage in their commercial practice. We study eight cases of UK-based charity retailers, in order to address the role of knowledge accumulation, articulation and codification process in the evolution of marketing capability development. We identify, amongst other things that the critical process of organizational learning for social enterprise is to transfer the experience into organization specific knowledge under the social aspects of constraints
Ko au te whenua, te whenua ko au – I am the land, the land is me: An autoethnographic investigation of a secondary school teacher’s experience seeking to enrich learning in outdoor education for Māori students.
No full textThis thesis is my story as an outdoor educator, as a researcher, and a co-participant reflecting on my own actions and experiences as well as those of my students. In this autoethnography I share my revelations and tensions in my role as an outdoor education teacher seeking to enrich the experiences of Māori students. Māori culture and history have largely been ignored in the outdoor education classrooms and environments of Aotearoa New Zealand. After teaching the subject for ten years I didn’t perceive that I was perpetuating the same invisibility in my own outdoor education course. Over this time a number of questions that had fermented at the back of my mind came to the fore; ‘why are so few Māori students opting to take outdoor education as a senior secondary school subject?’ and ‘how can I make the subject of outdoor education more desirable and appealing to Māori?’ A place-responsive approach incorporates and values traditional ways of learning through the notion of place and the stories attached to them. The cultural context of learning about and through place has the potential to provide learning opportunities that are relevant and meaningful to all learners but particularly Māori. Place-responsive pedagogies allow outdoor educators to create an environment where language, knowledge, culture and values are normal, valid and legitimate – contexts where Māori students can be themselves. Through this research I have found that the implementation of a place responsive approach has had significant implications for Year twelve outdoor education at Mount Maunganui College. The improvement in Māori student achievement and numbers selecting the subject have been affirming.
Ko au te whenua, te whenua ko au – I am the land, the land is m
KNOWLEDGE ACCUMULATION IN ASIAN PUBLIC ADMINISTRATION RESEARCH: A CRITICAL REVIEW
No full textGiven the growing controversy over the relevance of Anglo-Saxon style public administration to developing countries and a greater demand for more context-relevant theories of public administration in Asia, we should expect that Asian scholars achieve a certain level of knowledge growth in line with this controversy and demand. On the basis of the review of 8810 articles published in nine major international journals during 1990-2011, the author found that the number of articles on Asian public administration is very small, and there is no strong pattern of growth in this regard. In addition, there are very few studies adopting a comparative approach covering multiple Asian countries. Copyright (c) 2013 John Wiley & Sons, Ltd.N
Book-in-Common Conversation - Lisa Ko
No full textLisa Ko, author of The Leavers, will speak about her book and writing career in a virtual presentation on Tuesday, March 23 at 7 pm. Lisa Ko is the recipient of the 2016 PEN/Bellwether Prize and the 2017 Barnes and Noble Discover Great New Writers Award. The Leavers was also named best book of the year by NPR
Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice
No full textBackground: Recent progress in genomics has contributed to the identification of a large number of autism spectrum disorder (ASD) risk genes, many of which encode synaptic proteins. Our understanding of ASDs has advanced rapidly, partly owing to the development of numerous animal models. Extensive characterizations using a variety of behavioral batteries that analyze social behaviors have shown that a subset of engineered mice that model mutations in genes encoding Shanks, a family of excitatory postsynaptic scaffolding proteins, exhibit autism-like behaviors. Although these behavioral assays have been useful in identifying deficits in simple social behaviors, alterations in complex social behaviors remain largely untested. Methods: Two syndromic ASD mouse models—Shank2 constitutive knockout [KO] mice and Shank3 constitutive KO mice—were examined for alterations in social dominance and social cooperative behaviors using tube tests and automated cooperation tests. Upon naïve and salient behavioral experience, expression levels of c-Fos were analyzed as a proxy for neural activity across diverse brain areas, including the medial prefrontal cortex (mPFC) and a number of subcortical structures. Findings: As previously reported, Shank2 KO mice showed deficits in sociability, with intact social recognition memory, whereas Shank3 KO mice displayed no overt phenotypes. Strikingly, the two Shank KO mouse models exhibited diametrically opposed alterations in social dominance and cooperative behaviors. After a specific social behavioral experience, Shank mutant mice exhibited distinct changes in number of c-Fos+ neurons in the number of cortical and subcortical brain regions. Conclusions: Our results underscore the heterogeneity of social behavioral alterations in different ASD mouse models and highlight the utility of testing complex social behaviors in validating neurodevelopmental and neuropsychiatric disorder models. In addition, neural activities at distinct brain regions are likely collectively involved in eliciting complex social behaviors, which are differentially altered in ASD mouse models. © 2020, The Author(s).1
The Application of Critical Discourse Theory: A Criterion-Referenced Analysis of Reports Relating to Language Revitalisation in Australia and New Zealand
No full textThe discipline of language policy and planning (LPP) is often proposed as a viable tool for language revitalisation. However, the conventional paradigm upon which LPP is based is inadequate for such an inherently political, contentious and problematic area of social policy, and does not address the hegemonic and counter-hegemonic discourse that is at the very core of language revitalisation efforts. It is therefore argued here that LPP needs to be explicitly underpinned by critical discourse theory (CDT) if it is to be of genuine use to those involved in language revitalisation efforts, particularly to grass roots language activists. Following an introductory chapter which provides a background to the research and a rationale for it (Chapter 1), there is a critical review of selected literature on LPP and CDT, a review which ends by proposing a list of criteria which, it is argued, can be used to determine the extent to which discourse that is intended to be counter-hegemonic adheres to the principles of effective counter-hegemonic discourse as outlined in the literature on CDT (Chapter 2). In the following three chapters (Chapters 3, 4 & 5), these criteria are applied to the analysis of three recent reports that have a direct bearing on indigenous language revitalisation in Australia (Our Land Our Languages) and New Zealand (Ko Aotearoa Tēnei and Te Reo Mauriora). The first of these reports is found to adhere very closely to the criteria; the second less so; the third almost not at all. The different ways in which each of these reports has been received would tend to support the hypothesis that, other things being equal, the more closely a text of this type conforms to the criteria - that is, the more closely it is aligned to the fundamental principles of effective counter-hegemonic discourse as outlined in CDT - the more likely it is to be positively received and, therefore, to represent an effective challenge to the existing hegemony. The overall conclusion is that CDT can not only assist language activists by providing a basis for determining how successful counter-hegemonic discourse is likely to be in achieving its aims but has the potential to provide LPP with a secure theoretical foundation (Chapter 6)
Author response
No full textEpsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice. Triple KO cells displayed a dramatic cell division defect. Additionally, a robust impairment in clathrin-mediated endocytosis was observed, with an accumulation of early and U-shaped pits. This defect correlated with a perturbation of the coupling between the clathrin coat and the actin cytoskeleton, which we confirmed in a cell-free assay of endocytosis. Our results indicate that a key evolutionary conserved function of epsin, in addition to other roles that include, as we show here, a low affinity interaction with SNAREs, is to help generate the force that leads to invagination and then fission of clathrin-coated pits.Clathrin-dependent endocytosis is one of the mechanisms used by cells to internalize specific proteins (cargo) from their surface. First, the cargo interacts with adaptor proteins that help cluster them in the cell's outer membrane, called the plasma membrane. This causes the protein clathrin to assemble into a lattice at the cytosolic side of the plasma membrane and deform the membrane into a pit. The pit grows deeper over time as more clathrin molecules assemble, eventually resulting in a deeply invaginated clathrin-coated pit that encloses the cargo to be taken up by the cell. The clathrin-coated pit then pinches off inside the cell in a process called fission to form a bubble-like structure called a vesicle, which transports the molecule to its destination. The deep invagination of clathrin-coated pits that leads to fission is assisted by actin, a protein that assembles into filaments that are suggested to generate the forces needed for this process. Many other factors are also involved. One of them is epsin, the collective name for a family of three very similar proteins in mammalian cells. Epsin binds to several other proteins implicated in clathrin-dependent endocytosis, including clathrin itself, and to plasma membrane proteins specifically ‘tagged’ for internalization. In addition, a portion of the epsin molecule can insert into the plasma membrane and help it to curve, which is important for forming the invaginated pit. However, due to the number of possible functions epsin could perform, its main role has remained elusive. Messa et al. created mouse cells that lack all three epsin proteins. Although these cells can form clathrin-coated pits, they struggle to develop into vesicles. The normal linking of the actin filaments to the clathrin coat does not occur, and another protein called Hip1R that also participates in clathrin-mediated endocytosis and links clathrin to actin, no longer accumulates at the clathrin-coated pits. Messa et al. also find that epsins can bind directly to actin. Overall, these results suggest that a main role of epsin is to help actin interact with the clathrin-coated pits and generate the force required for a pit to develop into a vesicle. However, epsin also performs many other roles, including recruiting a membrane protein (a so-called SNARE) that directs the fate of the vesicle to the clathrin-coated pit. Additionally, Messa et al. find that cells lacking all three epsins have problems dividing correctly. More research is required to establish whether this effect is also due to epsin's interaction with the cell's actin cytoskeleton.Epsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice. Triple KO cells displayed a dramatic cell division defect. Additionally, a robust impairment in clathrin-mediated endocytosis was observed, with an accumulation of early and U-shaped pits. This defect correlated with a perturbation of the coupling between the clathrin coat and the actin cytoskeleton, which we confirmed in a cell-free assay of endocytosis. Our results indicate that a key evolutionary conserved function of epsin, in addition to other roles that include, as we show here, a low affinity interaction with SNAREs, is to help generate the force that leads to invagination and then fission of clathrin-coated pits.Clathrin-dependent endocytosis is one of the mechanisms used by cells to internalize specific proteins (cargo) from their surface. First, the cargo interacts with adaptor proteins that help cluster them in the cell's outer membrane, called the plasma membrane. This causes the protein clathrin to assemble into a lattice at the cytosolic side of the plasma membrane and deform the membrane into a pit. The pit grows deeper over time as more clathrin molecules assemble, eventually resulting in a deeply invaginated clathrin-coated pit that encloses the cargo to be taken up by the cell. The clathrin-coated pit then pinches off inside the cell in a process called fission to form a bubble-like structure called a vesicle, which transports the molecule to its destination. The deep invagination of clathrin-coated pits that leads to fission is assisted by actin, a protein that assembles into filaments that are suggested to generate the forces needed for this process. Many other factors are also involved. One of them is epsin, the collective name for a family of three very similar proteins in mammalian cells. Epsin binds to several other proteins implicated in clathrin-dependent endocytosis, including clathrin itself, and to plasma membrane proteins specifically \‘tagged\’ for internalization. In addition, a portion of the epsin molecule can insert into the plasma membrane and help it to curve, which is important for forming the invaginated pit. However, due to the number of possible functions epsin could perform, its main role has remained elusive. Messa et al. created mouse cells that lack all three epsin proteins. Although these cells can form clathrin-coated pits, they struggle to develop into vesicles. The normal linking of the actin filaments to the clathrin coat does not occur, and another protein called Hip1R that also participates in clathrin-mediated endocytosis and links clathrin to actin, no longer accumulates at the clathrin-coated pits. Messa et al. also find that epsins can bind directly to actin. Overall, these results suggest that a main role of epsin is to help actin interact with the clathrin-coated pits and generate the force required for a pit to develop into a vesicle. However, epsin also performs many other roles, including recruiting a membrane protein (a so-called SNARE) that directs the fate of the vesicle to the clathrin-coated pit. Additionally, Messa et al. find that cells lacking all three epsins have problems dividing correctly. More research is required to establish whether this effect is also due to epsin's interaction with the cell's actin cytoskeleton
Personel motivation in organization Ltd. "Lage Ko".
No full textPersonāla vadībā būtiska loma ir motivācijas procesam. Motivēšanas problēma ir bijusi aktuāla visos laikos, un arī pašlaik tās nozīme nav zudusi. Bez pareizas motivācijas ir grūti panākt darbinieku maksimālu atdevi savam darbam, kas savukārt ietekmē uzņēmuma turpmāko attīstību. Bakalaura darba mērķis ir identificēt nozīmīgākās motivēšanas problēmas uz izstrādāt priekšlikumus motivācijas pilnveidošanai. Lai sasniegtu mērķi, tiek analizēts uzņēmums SIA „Lage Ko”, kā arī aptaujāti darbinieki, lai uzzinātu viņu viedokli par motivāciju uzņēmumā. Izvirzītā mērķa sasniegšanai veicamie uzdevumi: izpētīt motivācijas teorētisko bāzi, apskatīt informāciju par motivāciju Latvijā, sniegt uzņēmuma vispārējo raksturojumu un veikt tā SVID analīzi, veikt potenciālo darbinieku un uzņēmuma darbinieku motivācijas analīzi izmantojot anketas, izvērtēt darbinieku anketēšanas rezultātus un formulēt tiem atbilstošus secinājumus, sagatavot priekšlikumus motivācijas pilnveidošanai uzņēmumā. Darba autore apkopoja un izanalizēja darbinieku motivēšanas teorētiskos aspektus, apskatīja motivācijas teorijas un veidus, kā arī aplūkoja aktuālās motivēšanas problēmas Latvijā. Autore sniedza uzņēmuma SIA „Lage Ko” raksturojumu, izanalizēja organizatorisko struktūru, kā arī izklāstīja veikto SVID analīzi, veica potenciālo darbinieku aptauju par motivācijas faktoriem, kuri būtu nozīmīgi meklējot jaunu darbu. Autore veica uzņēmuma SIA „Lage Ko” darbinieku motivācijas analīzi ar aptaujas palīdzību, lai novērtētu motivāciju, atklātu aktuālās problēmas un sniegtu motivācijas pilnveidošanas iespējas uzņēmumā. Nobeigumā darba autore sagatavoja secinājumus par uzņēmumā pastāvošo darbinieku motivāciju un sniedza priekšlikumus tās pilnveidošanai.In personnel development motivation process plays a significant role. The issue of motivation has been a topic of discussion at all times, and it has not lost it’s significance in the present. Without the correct motivation approach in place it is difficult to achieve maximum employee dedication to their work, which, in turn, affects the future activity of the company. The aim of the Bachelor’s work is to identify the significant problems in the area directly connected to motivation and to propose future improvements. To achieve the aim, author analyzes the organization Ltd. "Lage Ko" as well as surveyes employees to find out their views on the motivation of the company. In order to achieve the aim, the following tasks were set in advance: to study the theoretical basis of the motivation, to view information about the motivation in Latvia, to provide a general description of the enterprise and make its SWOT analysis, to carry out a potential employee and the company’s employee motivation analysis by using survey questionnaires, to assess the employee survey results and draw appropriate conclusions, to put forward suggestions for improving the personnel motivation. The author summarized and analyzed theoretical aspects of motivation, examined the motivational theories and types, as well as looked at the existing motivation problems in Latvia. The author defined Ltd. "Lage Ko" main characteristics, analyzed the organizational structure, set out the SWOT analysis and made a survey on potential employee motivation factors, which could be important in the search for a new job. The author made a motivation analysis basing on the employees of the Ltd. „Lage Ko” views with the help of a questionnaire in order to assess motivation, detect current problems and provide opportunities for improving motivation within the company and outside it. In conclusion, the author drew up conclusions on the companies existing personnel motivation and made proposals for its improvement
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