785 research outputs found
Effects of Participatory and Physical Life Goals in a Preventive Care Program for Frail Community-Dwelling Older People: A Retrospective Cohort Study
No full textAbstract
Date Presented 3/31/2017
Life goals related to activities and participation had a more positive effect on frail older people’s health and quality of life than did life goals related to physical function and structure. The setting of meaningful goals may help to improve the effectiveness of preventive care programs.
Primary Author and Speaker: Yoshimi Yuri
Additional Authors and Speakers: Shinichi Takabatake, Yoko Tsuji, Yuri Fujii, Toshikatsu Kaneda, Yasuhiro Higashi, Hiroko Hashimoto, Kazuyo Nakaoka, Mari Oka</jats:p
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
No full text主査：岡田 斉 教授
学内授与番号：医第1425号This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara, Naoya Omaru, Natsuki Okai, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Hajime Honjo, Yasuyuki Arai, Kouhei Yamashita, Masatoshi Kudo, Tomohiro Watanabe "Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression" International Immunology, Volume 35, Issue 2, February 2023, Pages 79–94] is available online at: [https://doi.org/10.1093/intimm/dxac045]
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
No full text近畿大学Kindai University博士（医学）主査：岡田 斉 教授
学内授与番号：医第1425号This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara, Naoya Omaru, Natsuki Okai, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Hajime Honjo, Yasuyuki Arai, Kouhei Yamashita, Masatoshi Kudo, Tomohiro Watanabe "Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression" International Immunology, Volume 35, Issue 2, February 2023, Pages 79–94] is available online at: [https://doi.org/10.1093/intimm/dxac045].doctoral thesi
Evaluation of LIPS (luciferase immunoprecipitation system) for serodiagnosis of Toxoplasmosis
No full textCitation:
Aye KM, Nagayasu E, Baba M, Yoshida A, Takashima Y, Maruyama H. Evaluation of LIPS (luciferase immunoprecipitation system) for serodiagnosis of Toxoplasmosis. J Immunol Methods. 2018 Nov;462:91-100. doi: 10.1016/j.jim.2018.09.002. Epub 2018 Sep 8. PMID: 30201391
Suspense in Philostratus' Apollonius
No full textThis paper aims to show the ways in which suspense works in Philostratus' Apollonius. The author tries to keep his narrative unsurprising by making use of the ‘basic narrative pattern', a template which guarantees Apollonius' victory over any rival character he meets during his worldwide travels. We repeatedly find the protagonist gaining an upper hand over other socially distinguished figures and, through that process, come to be able to keep ourselves calm in the face of whatever happens to the Tyanean sage. The established pattern also allows the author to arrange his episodes in any order he wants because whatever he tells us in a given episode, his goal is always the same --the winner is Apollonius. So basically we have no choice but to acknowledge that Apollonius' conversations, which cover a large part of the work, are predictable and that the whole narrative is quite loosely structured. We, however, have the two important exceptions: the Nero episode and the Domitian episode. In these episodes, we can find Philostratus taking special care of his narrative arrangement to make the episodes exciting to read. More precisely, the author offers us various kinds of suspense, by which he makes the reader uncertain of the future of the protagonist, who is confronted with Nero's and Domitian's threatening antipathy. Even though we can expect Apollonius' victory over the tyrants relying on the ‘basic narrative pattern', still we cannot easily dismiss the possibility of his subordination to them. From these observations, we can conclude that Philostratus is not always an unthinking cataloguer. At least in the two episodes that feature Apollonius' conflict with the ‘anti-philosophy' emperors, the author can be seen as a sophisticated storyteller who struggles to entertain his readers by carefully arranging narrative components
Pluripotent stem cells for the study of early human embryology
No full textForty years have passed since the first pluripotent stem cells (PSCs), mouse embryonic stem cells (ESCs), were established. Since then, several PSCs have been reported, including human ESCs in 1998, mouse epiblast stem cells (EpiSCs) in 2007, induced PSCs (iPSCs) in 2006 and 2007, and naïve human PSCs in 2014. Naïve PSCs are thought to correspond to pre-implantation epiblast cells, whereas conventional (or primed) human PSCs correspond to post-implantation epiblast cells. Thus, naïve and primed PSCs are classified by their developmental stages and have stage-specific characteristics, despite sharing the common feature of pluripotency. In this review, we discuss the current status of PSCs and their use to model human peri-implantation development
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