1,721,079 research outputs found
Corea Reumatica: tre "C" che dicono tutto
No full textÈ proprio il caso di dirlo: rara ma non troppo. La corea reumatica non è una condizione che abbiamo studiato a scuola e che non vedremo mai. Può capitare a ognuno di imbattersi in un caso e non sarebbe perdonabile non ri- conoscerla prontamente (non averne ben chiare le peculiarità cliniche, le modalità di comparsa, la frequente as- sociazione con la cardite) e non saperla trattare adeguatamente (cortisone). Tre “C” appunto (Corea, Cardite, Cortisone) che sostanzialmente ci aiutano a ricordare tutto
Young child with painful edema and purpura: a case report
Full text linkBackground: We reported the case of a two-old-year boy with a painful acute hemorrhagic edema. This is a self-limited benign condition: usually, affected children are well appearing and this strongly support the diagnosis. In the opposite, in our case, we observed a painful presentation of the edema. Therefore, we demonstrated that rarely, this condition could have also a painful presentation. Conclusions: This case report helps clinician to know that also acute hemorrhagic edema could have a painful presentation, so we must considered it in the differential diagnosis with sepsis, sickle cell crisis and child abuse. We believe that these findings will be of interest to pediatricians
Meckel's diverticulum masked by a long period of intermittent recurrent subocclusive episodes
No full textMeckel's diverticulum (MD) is the most frequent congenital abnormality of the small bowel and it is often difficult to diagnose. It is usually asymptomatic but approximately 4% are symptomatic with complications such as bleeding, intestinal obstruction, and inflammation. The authors report a case of a 7-year-old boy with a one-year history of recurrent periumbilical colicky pain with associated alimentary vomiting, symptoms erroneously related to a cyclic vomiting syndrome but not to MD. The clinical features and the differential diagnostic methods employed for diagnosis of MD are discussed. © 2009 The WJG Press and Baishideng. All rights reserved
Palmar erythema: A diagnostic clue of juvenile dermatomyositis
No full textAn 11-year-old girl presented with a 3-month history of myalgia ofthe upper and lower limbs, progressive severe asthenia and positiveGower’s sign. Erythema overlying the palmar surfaces of both hands(Fig. 1) had appeared in the last month without other skin signs.Blood tests showed elevated Creatine Kinase (1988 U/L), AspartateAminotransferase (112 U/L), aldolase (80 U/L) and Erythrocyte Sedi-mentation Rate (61 mm/h), with normal blood count, lactic acid andthyroid function. Echocardiography, abdominal ultrasound and eyeexamination were normal. Electromyography showed an inamma-tory pattern. Capillaroscopy showed a subversion of the capillaryarchitecture of the nail bed and microvascular alterations (Fig. 2).What is the most likely diagnosis
Hughes Stovin: Sustained remission and regression of pulmonary aneurysms with anti–tumor necrosis factor treatment
No full textWe report the first case of Hughes Stovin Syndrome successfully treated with long-lasting tumor necrosis factor α (TNF-α) blocker (infliximab) treatment. Because of the failure of the standard therapeutic regimen with steroids and cyclophosphamide, infliximab was started achieving a stable disease remission and a complete resolution of pulmonary aneurysms. Hughes Stovin Syndrome, although rare, is a life-threatening condition that needs to be timely identified and treated aggressively. Our report underlines the importance of TNF-α blocker treatment in Hughes Stovin Syndrome, suggesting its use as long-term safe and useful
A Case of Uveitis in a Patient with Juvenile Myelomonocytic Leukemia Successfully Treated with Adalimumab
Full text linkPatients with juvenile myelomonocytic leukemia due to germline CBL mutation (10% to 15%) may have a subacute course occasionally associated with autoimmune disorders, which may resemble RAS-associated autoimmune lymphoproliferative disorder. In both conditions, prognosis and standard treatment for autoimmune phenomena remain poorly understood. We report the case of a 7-year-old boy with juvenile myelomonocytic leukemia with severe steroid-dependent uveitis, who did not respond to several therapeutic attempts with immunosuppressant agents, including sirolimus, and was finally successfully treated with adalimumab. This case offers further insight into the management of autoimmune disorders in the context of predisposing genetic conditions
A 7-month-old boy with liver abscesses
No full textChronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. We report a case of a 7-month-old boy with liver abscesses, with final diagnosi of Chronic Granulomatous Diseas
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