2 research outputs found
Interchangeability between methane measurements in dairy cows assessed by comparing precision and agreement of two non-invasive infrared methods
No full textAbstractIn this study we assess the interchangeability and statistical agreement of two prevalent instruments from the non-invasive “sniffer” method and compare their precision. Furthermore, we develop and validate an effective algorithm for aligning time series data from multiple instruments to remove the effects of variable and fixed time shifts from the instrument comparison. The CH4 and CO2 gas concentrations for both instruments were found to differ for population means (P<0.05) and intra-cow variation (precision) (P<0.05) and for inter-cow variation (P<0.05). The CH4 and CO2 gas concentrations from both instruments can be used interchangeably to increase statistical power for example, in genetic evaluations, provided sources of disagreement are corrected through calibration and standardisation. Additionally, averaging readings of cows over a longer period of time (one week) is an effective noise reduction technique which provides phenotypes with considerable inter-cow variation
PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK
No full textAbstract
Background
Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.
Methods
All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.
Results
A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.
Conclusion
Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.
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