1,951 research outputs found
Ubiquitin reactive dystrophic axons have a widespread distribution in Creutzfeldt-Jakob disease
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Ubiquitin reactive neurites in cerebral cortex of subjects with Huntington's chorea: a possible correlate of dementia?
No full textThe molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein.
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Balance features in Alzheimer's disease and amnestic mild cognitive impairment
No full textAbstract. We evaluated alterations of balance by stabilometry in patients with amnestic mild cognitive impairment (aMCI) and
with mild-moderate Alzheimer’s disease (AD). Fifteen patients with aMCI and 15 with mild AD were recruited according to the
current diagnostic criteria. Fifteen healthy subjects of the same age range were recruited as controls. Stabilometry was carried out
using a commercial 4 load cell platform. Statistical analysis of between group differences was performed using one-way analysis
of variance for parametric data and Kruskal-Wallis tests for non-parametric data. Spearman correlation coefficients were used
to investigate the association between cognitive test scores and stabilometric data. All stabilometry measures were significantly
altered in mild AD patients compared to normal controls. Antero-posterior sway was found to be the most sensitive parameter,
since it correlated with the ADAS-cog orientation subscale in AD patients, and also discriminated between aMCI and normal
controls. Our study shows that impairment in balance is a feature not only of AD, but also of aMCI. The alterations found suggest
that a progressive failure of the vestibular system, possibly linked to reduced hippocampal performance, may be responsible for
such a feature. Further research must be focused on studying the predictive value of stabilometry in the conversion of aMCI
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