1,720,974 research outputs found
RADICAL IONS AND PHOTOCHEMICAL CHARGE-TRANSFER PHENOMENA .22. PRESSURE-INDUCED DIASTEREOSELECTIVITY IN PHOTOINDUCED DIELS-ALDER REACTIONS
No full textCHUNG WS, TURRO NJ, MERTES J, Mattay J. RADICAL IONS AND PHOTOCHEMICAL CHARGE-TRANSFER PHENOMENA .22. PRESSURE-INDUCED DIASTEREOSELECTIVITY IN PHOTOINDUCED DIELS-ALDER REACTIONS. The Journal of Organic Chemistry. 1989;54(20):4881-4887
Photolysis of 3-chlorodiazirine in the presence of alkenes. Kinetic evidence for intervention of a carbene-alkene intermediate in addition of chlorocarbene to alkene
No full textPT: J; CR: MOSS RA, 1978, J AM CHEM SOC, V100, P6788 MOSS RA, 1978, J CHEM SOC CHEM COMM, P755 MOSS RA, 1979, TETRAHEDRON LETT, P1277 MOSS RA, 1980, TETRAHEDRON LETT, V21, P2037 MOSS RA, 1981, TETRAHEDRON LETT, V22, P997 MOSS RA, 1983, TETRAHEDRON LETT, V24, P685 SU DTT, 1978, J AM CHEM SOC, V100, P1872 TOMIOKA H, 1980, J AM CHEM SOC, V102, P7123 TURRO NJ, 1980, J AM CHEM SOC, V102, P7576 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754; NR: 10; TC: 48; J9: J AMER CHEM SOC; PG: 3; GA: SA583Source type: Electronic(1
Pyridine ylide formation by capture of phenylchlorocarbene and tert-butylchlorocarbene. Reaction rates of an alkylchlorocarbene by laser flash photolysis
No full textPT: J; CR: BARCUS RL, 1986, J AM CHEM SOC, V108, P3928 CHATGILIALOGLU C, 1982, J AM CHEM SOC, V104, P5124 GOULD IR, 1985, TETRAHEDRON, V41, P1587 GRILLER D, 1984, J AM CHEM SOC, V106, P2227 LIU MTH, 1985, TETRAHEDRON LETT, V26, P3071 MOSS RA, 1981, TETRAHEDRON LETT, V38, P3749 SOUNDARARAJAN N, IN PRESS J AM CHEM S SOUNDARARAJAN N, IN PRESS TETRAHEDRON SOUNDARARAJAN N, UNPUB TURRO NJ, 1985, J ORG CHEM, V50, P4417 TURRO NJ, 1987, J AM CHEM SOC, V109, P2101 ZUGRAVESCU I, 1976, N YLID CHEM; NR: 12; TC: 144; J9: J AMER CHEM SOC; PG: 2; GA: P5279Source type: Electronic(1
Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry
No full textDNA sequencing by synthesis on a solid surface offers new paradigms to overcome limitations of electrophoresis-based sequencing methods. Here we report DNA sequencing by synthesis using photocleavable (PC) fluorescent nucleotides [dUTP-PC-4,4-difluoro-4-bora-3alpha,4alpha-diaza-s-indacene (Bodipy)-FL-510, dCTP-PC-Bodipy-650, and dUTP-PC-6-carboxy-X-rhodamine (ROX)] on a glass chip constructed by 1,3-dipolar azide-alkyne cycloaddition coupling chemistry. Each nucleotide analogue consists of a different fluorophore attached to the base through a PC 2-nitrobenzyl linker. We constructed a DNA microarray by using the 1,3-dipolar cycloaddition chemistry to site-specifically attach azido-modified DNA onto an alkyne-functionalized glass chip at room temperature under aqueous conditions. After verifying that the polymerase reaction could be carried out successfully on the above-described DNA array, we then performed a sequencing reaction on the chip by using a self-primed DNA template. In the first step, we extended the primer using DNA polymerase and dUTP-PC-Bodipy-FL-510, detected the fluorescent signal from the fluorophore Bodipy-FL-510, and then cleaved the fluorophore using 340 nm UV irradiation. This process was followed by extension of the primer with dCTP-PC-Bodipy-650 and the subsequent detection of the fluorescent signal from Bodipy-650 and its photocleavage. The same procedure was also performed by using dUTP-PC-ROX. The entire process was repeated five times by using the three fluorescent nucleotides to identify 7 bases in the DNA template. These results demonstrate that the PC nucleotide analogues can be incorporated accurately into a growing DNA strand during polymerase reaction on a chip, and the fluorophore can be detected and then efficiently cleaved using near-UV irradiation, thereby allowing the continuous identification of the template sequence.National Science Foundation Sensing and Imaging Initiative Grant 0097793, a Packard Fellowship for Science and Engineering, Center of Excellence in Genomic Science Grant P50 HG002806 from National Institutes of Healt
Termolecular trapping of benzylchlorocarbene by methanol
No full textPT: J; CR: GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, 1982, J AM CHEM SOC, V104, P5549 KIRMSE W, 1971, CARBENE CHEM LIU MTH, UNPUB LIU MTH, 1982, CHEM SOC REV, V11, P127 MOSS RA, 1973, CARBENES, V1 MOSS RA, 1975, CARBENES, V2 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754; NR: 9; TC: 14; J9: J CHEM SOC CHEM COMMUN; PG: 3; GA: TF969Source type: Electronic(1
Kinetics and mechanism of the thermal decomposition of N-nitrosodiphenylmethylimine
No full textPT: J; CR: AKIBA K, 1974, B CHEM SOC JPN, V47, P935 AKIBA K, 1977, HETEROCYCLES, V7, P1131 BAUMSTARK AL, 1976, TETRAHEDRON LETT, P2397 CALVERT JG, 1966, PHOTOCHEMISTRY HORN KA, 1978, MOL PHOTOCHEM, V9, P1 KOPECKY KR, 1969, CAN J CHEM, V47, P709 KOSOWER EM, 1958, J AM CHEM SOC, V80, P3253 REICHARDT C, 1965, ANGEW CHEM, V77, P30 SMITH SG, 1961, J AM CHEM SOC, V83, P618 THOMAN CJ, 1968, J ORG CHEM, V33, P2852 TURRO NJ, 1974, ACCOUNTS CHEM RES, V7, P97 TURRO NJ, 1978, MODERN MOL PHOTOCHEM VIS JH, 1970, J HETEROCYCLIC CHEM, V7, P1417 WOODWARD RB, 1965, J AM CHEM SOC, V87, P2046 WOODWARD RB, 1965, J AM CHEM SOC, V87, P2511 WOODWARD RB, 1965, J AM CHEM SOC, V87, P395 WOODWARD RB, 1965, J AM CHEM SOC, V87, P4385 WOODWARD RB, 1965, J AM CHEM SOC, V87, P4389 YASUDA M, 1980, J ORG CHEM, V45, P2368; NR: 19; TC: 1; J9: CAN J CHEM; PG: 4; GA: LE223Source type: Electronic(1
Benzylchlorocarbene: a new ambiphile
No full textPT: J; CR: GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1985, TETRAHEDRON LETT, V26, P3071 LIU MTH, 1987, CHEM DIAZIRINES, CH5 LIU MTH, 1987, J ORG CHEM, V52, P4223 MOSS RA, 1985, REACTIVE INTERMEDIAT, V3 MOSS RA, 1986, J AM CHEM SOC, V108, P7028 MOSS RA, 1987, TETRAHEDRON LETT, V28, P4779 SOUNDARARAJAN N, 1988, J AM CHEM SOC, V110, P7143 TURRO NJ, 1987, J AM CHEM SOC, V109, P4973; NR: 10; TC: 7; J9: J CHEM SOC CHEM COMMUN; PG: 3; GA: T0046Source type: Electronic(1
Addition of arylchlorocarbenes to .alpha.,.beta.-unsaturated esters. Absolute rates, substituent effects, and variable reactivities
No full textPT: J; CR: BALASUBRAMANIYA.V, 1983, TETRAHEDRON, V39, P1475 BEENS H, 1967, J CHEM PHYS, V47, P1183 BERSON JA, 1974, J AM CHEM SOC, V96, P6175 BERSON JA, 1974, J AM CHEM SOC, V96, P6177 BOWMAN RM, 1974, J AM CHEM SOC, V96, P692 BROWN WG, 1966, J AM CHEM SOC, V88, P233 CALDWELL RA, 1978, J AM CHEM SOC, V100, P2905 COX DP, 1983, TETRAHEDRON LETT, V24, P5313 CREED D, 1976, J AM CHEM SOC, V98, P621 DEHMLOW EV, 1984, ANGEW CHEM INT EDIT, V23, P706 DOYLE MP, 1984, TETRAHEDRON LETT, V25, P901 DOYLE MP, 1986, TETRAHEDRON LETT, V27, P4395 DOYLE MP, 1987, CHEM DIAZIRINES, CH8 GILBERT WI, 1939, J ORG CHEM, V3, P611 GORDON M, 1975, EXCIPLEX GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 HOUK KN, 1984, J AM CHEM SOC, V106, P4293 HOUK KN, 1985, TETRAHEDRON, V41, P1555 HUISGEN R, 1963, ANGEW CHEM INT EDIT, V2, P633 KNIBBE H, 1967, J CHEM PHYS, V47, P184 KWIE WW, 1963, TETRAHEDRON LETT, P405 LAMBERT JB, 1983, TETRAHEDRON LETT, V24, P3799 LEONHARDT H, 1963, BER BUNSEN PHYS CHEM, V63, P791 LIU MTH, 1987, CHEM DIAZIRINES, CH5 LIU MTH, 1987, J ORG CHEM, V52, P323 LIU MTH, 1987, J ORG CHEM, V52, P4223 LIU MTH, 1987, TETRAHEDRON LETT, V28, P1011 LOUTFY RO, 1969, J AM CHEM SOC, V91, P3984 MOSS RA, 1967, TETRAHEDRON LETT, P4905 MOSS RA, 1969, J ORG CHEM, V34, P2220 MOSS RA, 1970, J AM CHEM SOC, V92, P6951 MOSS RA, 1977, J AM CHEM SOC, V99, P4105 MOSS RA, 1979, J AM CHEM SOC, V101, P5088 MOSS RA, 1979, TETRAHEDRON LETT, P4721 MOSS RA, 1980, ACCOUNTS CHEM RES, V13, P58 MOSS RA, 1985, REACTIVE INTERMEDIAT, V3, CH3 MOSS RA, 1986, J AM CHEM SOC, V108, P7028 MOSS RA, 1987, TETRAHEDRON LETT, V28, P4779 NAZAKI K, 1941, J AM CHEM SOC, V63, P2585 OKADA T, 1968, J CHEM PHYS, V49, P4717 RONDAN NG, 1980, J AM CHEM SOC, V102, P1770 SAKAI M, 1977, B CHEM SOC JP, V50, P1232 SAUER J, 1967, ANGEW CHEM INT EDIT, V6, P16 SCHOELLER WW, 1982, ANGEW CHEM INT ED EN, V12, P932 SKELL PS, 1969, J AM CHEM SOC, V91, P7131 TANIGUCHI Y, 1972, CHEM PHYS LETT, V13, P596 TURRO NJ, 1980, J AM CHEM SOC, V102, P7578 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754 TURRO NJ, 1987, J AM CHEM SOC, V109, P4973 VAN SP, 1978, J AM CHEM SOC, V100, P3895 YANG NC, 1968, J AM CHEM SOC, V90, P5654; NR: 51; TC: 66; J9: J AMER CHEM SOC; PG: 10; GA: Q6555Source type: Electronic(1
Time-resolved-absorption spectroscopic detection of 10,10-dimethyl-10-silaanthracen-9(10H)-one oxide
No full textPT: J; CR: ANDO W, 1981, J SYN ORG CHEM JPN, V39, P613 BARTLETT PD, 1962, J AM CHEM SOC, V84, P3408 HAYASHI H, 1980, B CHEM SOC JPN, V53, P1519 KANAMARU N, 1970, B CHEM SOC JPN, V43, P3443 MURRAY RW, 1971, J AM CHEM SOC, V93, P4963 SAWAKI Y, 1981, J AM CHEM SOC, V103, P3832 SEKIGUCHI A, 1982, TETRAHEDRON LETT, V23, P4095 STEWART R, 1963, CAN J CHEM, V41, P1065 SUGAWARA T, 1983, CHEM LETT TURRO NJ, 1980, IEEE J QUANTUM ELECT, V16, P1218; NR: 10; TC: 47; J9: CHEM LETT; PG: 2; GA: RB995Source type: Electronic(1
on the thermal decomposition of diazirines
No full textPT: J; CR: BIGOT B, 1978, J AM CHEM SOC, V100, P6576 BRADLEY GF, 1977, J CHEM SOC P2, P1214 BRUNNER J, 1980, J BIOL CHEM, V255, P3313 DIDERICH G, 1972, HELV CHIM ACTA, V55, P2103 FLEMING I, 1980, FRONTIER ORBITALS OR GRILLER D, 1982, J AM CHEM SOC, V104, P5549 JENNINGS BM, 1976, J AM CHEM SOC, V98, P6416 LAHMANI F, 1976, J PHYS CHEM-US, V80, P2623 LANGANIS ED, 1983, J AM CHEM SOC, V105, P7457 LIU MTH, 1972, J PHYS CHEM-US, V76, P797 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1974, J CHEM SOC P2, P937 LIU MTH, 1977, CAN J CHEM, V55, P3596 LIU MTH, 1982, CHEM SOC REV, V11, P127 MOORE CB, 1964, J CHEM PHYS, V41, P3504 SCHMITZ E, 1965, CHEM BER, V98, P2509 SCHMITZ E, 1967, CHEM BER, V100, P2093 SCHMITZ E, 1971, 23RD INT C PUR ALL C, V2, P283 SHEPARD RA, 1967, J ORG CHEM, V32, P3197 SHILOV AE, 1968, TETRAHEDRON LETT, P4177 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686 SNYDER JP, 1972, TETRAHEDRON LETT, P4347 TAYLOR EC, 1979, CHEM REV, V79, P181 TURRO NJ, 1980, J AM CHEM SOC, V102, P7576 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754 VOIGT E, 1975, CHEM BER, V108, P3326 ZOLLINGER H, 1978, ANGEW CHEM INT EDIT, V17, P141; NR: 28; TC: 8; J9: J CHEM SOC PERKIN TRANS 2; PG: 4; GA: A2035Source type: Electronic(1
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