1,721,116 research outputs found
A parathyroid carcinoma within a cold thyroid nodule
No full textWe report the case of a 71-year-old woman who was referred to our institute with a solid nodule in the right thyroid lobe and hypercalcemia. Ultrasound revealed a well-vascularized right thyroid nodule that was identified as a cold area by 99mTc-sodium pertechnetate scan. Fine-needle aspiration showed a follicular lesion and blood tests revealed hypercalcemia and hyperparathyroidism. A 99mTc-methoxyisobutylisonitrile (99mTc-Sestamibi) scan was subsequently performed revealing a focal area of increased uptake in the right thyroid lobe, within the cold area detected by the thyroid scan. A right emithyroidectomy and right superior and inferior parathyroidectomy was performed and histopathological examination showed a parathyroid carcinoma (immunohistochemistry positive for PTH and chromogranin A, Ki-67 10%) associated with follicular hyperplasia
Contralateral or bilateral lymph drainage revealed by breast lymphoscintigraphy
No full textNo abstract availabl
Hepatic Safety of Antibiotics in Paediatric Primary Care: A Case-Control Study Using Electronic Healthcare Databases
No full textRisk of ischemic stroke associated with antidepressant drug use in elderly persons
No full textCompeting hypotheses have been formulated about a possible association between selective serotonin reuptake inhibitors (SSRIs) and ischemic stroke. However, the relationship between antidepressant drug use and ischemic stroke is still unclear. The aim of the study was to assess the association between the use of different types of antidepressants and the risk of ischemic stroke in elderly outpatients. A population-based, nested, case-control study was conducted in persons 65 years and older in the Integrated Primary Care Information database (1996-2005). Cases were all patients with a validated first ischemic stroke. Controls were matched on year of birth, sex, and index date. Exposure to antidepressants was divided in current, past, and nonuse and further categorized by type (SSRI, tricyclic, and other antidepressants), dose, and duration. Conditional logistic regression was used to compare the risk of ischemic stroke between users of antidepressants and nonusers. Overall, 996 incident ischemic strokes were identified. Current use of SSRIs was associated with a significantly increased risk as compared with nonuse (odds ratio, 1.55; 95% confidence interval, 1.07-2.25) in elderly patients, particularly when used for less than six months. No associations were observed for current use of tricyclic and other antidepressant drugs. To summarize, compared with nonuse, only SSRI use seems to be associated with an increased risk of ischemic stroke in elderly patients, particularly as a short-term effect
Detection of a cardiac mass by [18F]FDG-PET/CT: A rare case
No full textIntra-cardiac masses present an important problem in cardiology. The differential diagnosis includes tumours, which may be primary (benign or malignant) or metastatic, and infected mural thrombi. Myxomas, sarcomas, breast, lung, and renal cancer represent the commonest causes of primary benign, malignant and metastatic intra-cardiac masses respectively. Recent studies have shown that cardiac involvement in malignant lymphoma is common but under-investigated. Diagnostic imaging techniques for detection of cardiac masses include echocardiography, CT and MRI, with echocardiography having the highest sensitivity. We propose that 18-F-PET/CT may play an important role in the detection and evaluation of intra-cardiac masses
Antibiotics and Liver Injury in Paediatric Primary Care: a Case-Control Study using Healthcare Database Network
No full textPaediatric Acute Liver Injury: Signal Detection Using Multiple Healthcare Databases from the EU-ADR Network
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