90,307 research outputs found
Trattamento dell’epatopatia alcolica
No full textIl consumo eccessivo di alcol (>30 g/die) può essere la causa principale di una serie di danni epatici che, a loro volta, determinano diverse condizioni anatomo-cliniche, di cui una acuta, l'epatite alcolica, e le altre croncihe, quali la steatosi, la steatoepatite, la fibrosi/ cirrosi
Riforme agrarie e mutamenti sociali nell’Uzbekistan dell’era dell’Indipendenza
No full textCotton farming in Uzbekistan has been thoroughly reshaped by protracted decollectivization aimed at recovering agriculture from the post-Soviet crisis years. Based on a review of extant literature and on data collected over a socio-anthropological research in cotton-growing Khorezm region, this paper offers an overview over the Soviet-era cotton kolkhoz, post-Soviet agricultural reforms and agropolicies, and the transformations in rural society over the second post-Soviet decade. Agriculture in Uzbekistan is now resurfacing from difficult years, but old problems are perduring and prospects and burdens are more unequally distributed among stakeholders
Time to move beyond the classical prognostic systems for patients with advanced hepatocellular carcinoma undergoing Sorafenib
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Tuftsin deficiency
No full textTuftsin is a biologically active tetrapeptide (Thr-Lys-Pro-Arg) that stimulates the functions of macrophages and polymorphonuclear granulocytes, such as motility, phagocytosis, immunogenicity, hexose monophosphate shunt activation and bactericidal and tumoricidal activities [1]. Tuftsin deficiency can be both congenital and acquired.
The congenital form derives from a mutation in tuftsin tetrapeptide. The clinical manifestations are related to widespread infections, which are particularly severe in early childhood, while adults only present with mild symptoms or can even be asymptomatic. The most common infections involve the respiratory tract (pharingytis, tonsilitis, bronchitis, pneumonia) and skin and can be complicated by septicemia. Streptococcus pneumoniae, Staphylococcus aureus and Candida albicans are the most frequent causative agents [2].
Acquired tuftsin deficiency has been documented in different conditions sharing a reduced splenic function, such as splenectomy, myelocytic leukemia or myelofibrosis, idiopathic thrombocytopenic purpura, sickle cell disease, acquired immunodeficiency syndrome and acquired immunodeficiency syndrome related complex, short bowel syndrome, coeliac disease and liver cirrhosis [2-4]. All these conditions are characterized by increased susceptibility to bacterial infections and it is likely that tuftsin deficiency contributes to this abnormality
The ITA.LI.CA Consortium: How multicentre collaboration helped shape the management of patients with hepatocellular carcinoma on the basis of real-world evidence
No full textThe growing diffusion of digitalisation and informatics has promoted the creation and analysis of large databases able to provide solid information. Analyses of “big data” generated by real-world practice are particularly useful for knowing incidence and mortality, disparities, temporal trends of diseases, identifying risk factors, predicting future scenarios, obtaining inputs for cost-effectiveness and treatment benefit modelling, designing new studies, and monitoring rare diseases. Although randomised controlled trials (RCTs) represent the gold-standard for generating evidence about new diagnostic, preventive or therapeutic procedures, their results should be integrated with real-world data to personalise patient management. Indeed, a substantial proportion of patients observed in field-practice have characteristics that prevent the access to RCTs or, when included, form sub-groups too small to provide robust post-hoc analyses. Furthermore, as RCTs are resource-consuming and designed to maximize the probability of success, they are generally performed in expert centres of high-income areas, excluding economically-deprived regions which could complementarily contribute to the medical progress as huge sources of real-world data. These considerations fuelled the creation in 1998 of the Italian Liver Cancer (ITA.LI.CA) consortium, with the aim to merge data of patients with hepatocellular carcinoma (HCC) managed in several centres. This cooperation permitted to analyse a multicentre, large cohort of HCC patients. Since then, the ITA.LI.CA group has progressively expanded to currently include 24 centres, and its database counts more than 9,000 patients. This article describes the history of the ITA.LI.CA consortium and presents its scientific production whose results greatly contributed to the incessant improvement of HCC management
Distance measures for exploring pairs of novels in a large corpus of Italian literature
No full textIn text clustering most distance-based methods summarize the occurrences of a set of linguistic features to obtain a distance. It should decrease when texts are written by the same author, however, there are further properties that might influence the result: gender of the authors, their age, their geographical origin, publication date of the novels, their size, etc. In this study, regression analyses compare the performance of three distances and highlight, among available covariates, the preeminent effect of the author's hand but also interesting patterns in the effect of novels’ size
Improving survival of cirrhosis patients with hepatocellular carcinoma through application of standard of care
No full textAlcol ed apparato gastro-enterico.
No full textL'abuso di alcol comporta un danno a carico di numerosi organi e apparati, determinando quadri patologici diversi a seconda che si tratti di un insulto acuto o ripetuto nel tempo. Tuttavia, poiché quasi il 90% dell'alcol ingerito raggiunge, attraverso il sangue portale, il fegato e qui viene metabolizzato, questo organo presenta una particolare suscettivilità al danno prodotto dall'uso inappropriato di questa sostanza
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