1,721,123 research outputs found
Soluble beta amyloid in a continuum from physiology to pathology: searching the determinants of its effects and designing new pharmacological treatments
No full textModulation of striatal serotonin and metabolite levels by nitric oxide: an in vivo microdialysis study
No full textImpact of early life stress on psychiatric disorders: searching new biomarkers and innovative pharmacological targets
No full textPharmacological targeting of redox regulation systems as new therapeutic approach for psychiatric disorders: A literature overview
No full textRedox dysregulation occurs following a disequilibrium between reactive oxygen species (ROS) producing and degrading systems, i.e. mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and nitric oxide synthase (NOS) on one hand and the principal antioxidant system, the glutathione, on the other hand. Increasing recent evidence points towards a pathogenetic role of an altered redox state in the development of several mental disorders, such as anxiety, bipolar disorders, depression, psychosis, autism and post-traumaticstress disorders (PTSD). In this regard, pharmacological targeting of the redox state regulating systems in the brain has been proposed as an innovative and promising therapeutic approach for the treatment of these mental diseases. This review will summarize current knowledge obtained from both pre-clinical and clinical studies in order to descant "lights and shadows" of targeting pharmacologically both the producing and degrading reactive oxygen species (ROS) systems in psychiatric disorders
Composition of the essential oils of fruits from polyploid types of Thapsia Villosa L: chemotaxonomic evaluation
No full textNitric oxide can differentially modulate striatal neurotransmitter concentrations via soluble guanylate cyclase and peroxynitrite formation
No full textInvolvement of cGMP and ONOO- formation in the neuromodulatory effects of nitric oxide in the central nervous system
No full textAre neuromodulatory effects of nitric oxide in the striatum mediated cGMP or peroxynitrite formation?
No full text
- …
