1,721,000 research outputs found
MALATTIA DI DENT: CARATTERIZZAZIONE MOLECOLARE DELLA REGIONE DEL PROMOTORE DEL GENE CLCN5
No full textStudio della modulazione genica di TGF-beta1 da parte di diverse formulazioni di GAGs mediante Real Time PCR e chimica SYBR Green I in cellule mesangiali in vitro.
No full textDent's disease: Hereditary nephrolothiasis related to defective tubular endocytosis processes
No full textANALISI DEL PATHWAY MEDIATO DA SMAD DURANTE LA TRANSIZIONE EPITELIO-MESENCHIMALE INDOTTA DA TGFbeta1 IN CELLULE HUTEC IN COLTURA PRIMARIA
No full textMolecular characterization of the promoter region of the CLCN5 gene and expression study of 5'UTR isoforms in healthy and diseased kidneys
No full textIn search of adult renal stem cells
No full textAbstract
The therapeutic potential of adult stem cells in the treatment of chronic degenerative diseases has becoming increasingly evident over the last few years. Significant attention is currently being paid to the development of novel treatments for acute and chronic kidney diseases too. To date, promising sources of stem cells for renal therapies include adult bone marrow stem cells and the kidney precursors present in the early embryo. Both cells have clearly demonstrated their ability to differentiate into the kidney's specialized structures. Adult renal stem cells have yet to be identified, but the papilla is where the stem cell niche is probably located. Now we need to isolate and characterize the fraction of papillary cells that constitute the putative renal stem cells. Our growing understanding of the cellular and molecular mechanisms behind kidney regeneration and repair processes - together with a knowledge of the embryonic origin of renal cells - should induce us, however, to bear in mind that in the kidney, as in other mesenchymal tissues, the need for a real stem cell compartment might be less important than the phenotypic flexibility of tubular cells. Thus, by displaying their plasticity during kidney maintenance and repair, terminally differentiated cells may well function as multipotent stem cells despite being at a later stage of maturation than adult stem cells. One of the major tasks of Regenerative Medicine will be to disclose the molecular mechanisms underlying renal tubular plasticity and to exploit its biological and therapeutic potential
International Dent’s disease Registry: una opportunità per le ricadute cliniche e le prospettive di ricerca nella malattia di Dent.
No full text
La malattia di Dent nell'uremia e prevalenza della calcolosi renale nei dializzati: lo studio veneto
No full textGiornale Italiano di Nefrologia Anno 21 (S-29) S4
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