1,721,219 research outputs found
IMPIEGO DELLE 2-ALOGENOPIRIDINE-N-OSSIDO NELLA CHIMICA DEI PEPTIDI. USO DELLA 2-FLUOROPIRIDINA-N-OSSIDO PER LA DEMOLIZIONE-N-GRADUALE
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The renascence of fibrates in the management of dyslipidemia: from myopathy to activation of peroxisome proliferator-activated receptors (PPARs)
No full textSynthesis and biological evaluation of pyrrolidine derivatives as new ligands of AT1 receptors
No full textStudi stereochimici su prodotti da sintesi stereoselettive, di composti di interesse farmaceutico
No full textrisoluzione cinetica parziale dell'acido (±)-2-fenilbutirrico con alfa-ariletilammine omochirali: condizioni sperimentali e stereoselettività
No full textChloride channels of skeletal muscle from developing, adult and aged rats are differently affected by enantiomers of 2-(p-chlorophenoxy) propionic acid
No full textEnantiomers of 2-(p-chlorophenoxy) propionic acid, compounds acting specifically on chloride channels of adult rat skeletal muscles, have been tested on extensor digitorum longus (EDL) muscle of developing and aged rats, in an attempt to characterize the chloride channels responsible for the low chloride conductance (G(Cl)) found in the above physiological situations. The S-(-) enantiomer, which produces a concentration-dependent inhibition of G(Cl) in the adult EDL, is less effective in inhibiting G(Cl) of EDL of either 2-3 weeks or 29 months old rats, particularly at low concentrations. The R-(+) isomer, which in the adult enhances G(Cl) at low concentrations and blocks it at concentrations higher than 10 μM, lacks inhibitory action, enhancing G(Cl) in both developing and aged EDL. At 30 - 40 days of age both the enantiomers produce almost the same effects exerted in adulthood. From these data we hypothesize that the low C(Cl) found in EDL of developing and aged rats might be due not only to a lower number of conductive channels but also to the presence of a mixed population of isoforms of chloride channels having different pharmacological properties.
Risoluzione cinetica parziale dell'acido 2-fenilbutirrico con alpha-ariletilammine omochirali: condizioni sperimentali e stereoselettività
No full textDissociazione dell'attività farmacologica di strutture chirali: derivati della tocainide e mexiletina
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