1,721,072 research outputs found
Neurotrophic factors and longevity: an evolutionary view of the role of brain in regulating lifespan.
No full textTenascin-C expression in the trunk of wild type, cyclops and floating head zebrafish mutant embryos.
No full textActivity-dependent expression of Brain Derived Neurotrophic Factor in dendrites: facts and open questions.
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BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress
No full textThe neurotrophin brain-derived neurotrophic factor (BDNF) is a key survival factor for neural cells. In particular, in neuroblastoma tumour cells, expression of the BDNF/TrkB autocrine signalling system promotes a more malignant phenotype and resistance to chemotherapy. The human BDNF gene contains two clusters of upstream exons encoding the 5 UTR (exon 1 to exon 3 and exon 4 to exon 9a), these are alternatively spliced to a common exon 9, which contains the coding region and the 3 UTR. At least 34 different BDNF mRNA transcripts can be generated, although their physiological role is still unknown. The purpose of this study is to determine which BDNF transcript is involved in cell survival of the human neuroblastoma cell lines SH-SY-5Y (single-copy MYCN) and SK-N-BE (amplified MYCN). Expression of human BDNF mRNAs encoding all possible isoforms was characterised in the two neuroblastoma cell lines. We then investigated whether selective silencing of the different BDNF mRNAs using spec
Evolutionary conserved mechanisms of RNA trafficking in neurons and the regulation of spine morphology.
No full textBDNF induces BDNF and TrkB mRNA dendritic targeting through a PI-3 kinase-dependent mechanism
No full textEffects of cyclic nucleotides and Calcium/Calmodulin on protein phosphorylation in the CNS of Hirudo medicinalis.
No full textIs Altered BDNF Biosynthesis a General Feature in Patients with Cognitive Dysfunctions?
No full textSevere cognitive deficits are a frequent outcome of both neurodegenerative and neurodevelopmental disorders. In the attempt to define new clinical biomarkers, current research trends aim at the identification of common molecular features in these pathologies rather than searching for differences. Brain-derived neurotrophic factor (BDNF) has attracted great interest as possible biomarker because of its key role in synaptic remodeling during cognitive processes. BDNF undergoes proteolytic processing and studies in animal models have highlighted that different forms of learning and memory require either the proBDNF precursor or the mature BDNF form. Significantly, an altered expression of BDNF forms was found in postmortem brains and serum from patients with schizophrenia, Alzheimer’s disease and mood disorders. Based on these studies, this review puts forward the hypothesis that abnormalities in proBDNF or mBDNF biosynthesis may correspond to different cognitive dysfunctions in these brain diseases, while the role of truncated BDNF remains unknown
Coexpression of TrkB and the NMDAR subunits NR1-C1, NR2A, NR2B in the rat visual cortex.
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