179,559 research outputs found
Thun. Blümlisalp & Niesen : Thun, Einfahrt in den Thuner See
No full textAnonyme/r Fotograf/inPhotochrom-Nummer "212.P.Z." -- unten links in GoldAuf der Unterlage hanschriftlich bezeichnet: "VII" (oben) und "Thun, Einfahrt in den Thuner See" (unten
Identification of candidate genes and physiological pathways involved in gonad deformation in whitefish (Coregonus spp.) from Lake Thun, Switzerland
No full textIn 2000, fishermen reported the appearance of deformed reproductive organs in whitefish (Coregonus spp.) from Lake Thun, Switzerland. Despite intensive investigations, the causes of these abnormalities remain unknown. Using gene expression profiling, we sought to identify candidate genes and physiological processes possibly associated with the observed gonadal deformations, in order to gain insights into potential causes. Using in situ-synthesized oligonucleotide arrays, we compared the expression levels at 21,492 unique transcript probes in liver and head kidney tissue of male whitefish with deformed and normally developed gonads, respectively. The fish had been collected on spawning sites of two genetically distinct whitefish forms of Lake Thun. We contrasted the gene expression profiles of 56 individuals, i.e., 14 individuals of each phenotype and of each population. Gene-by-gene analysis revealed weak expression differences between normal and deformed fish, and only one gene, ictacalcin, was found to be up-regulated in head kidney tissue of deformed fish from both whitefish forms, However, this difference could not be confirmed with quantitative real-time qPCR. Enrichment analysis on the level of physiological processes revealed (i) the involvement of immune response genes in both tissues, particularly those linked to complement activation in the liver, (ii) proteolysis in the liver and (iii) GTPase activity and Ras protein signal transduction in the head kidney. In comparison with current literature, this gene expression pattern signals a chronic autoimmune disease in the testes. Based on the recent observations that gonad deformations are induced through feeding of zooplankton from Lake Thun we hypothesize that a xenobiotic accumulated in whitefish via the plankton triggering autoimmunity as the likely cause of gonad deformations. We propose several experimental strategies to verify or reject this hypothesis
Was war nach der Schlacht von Jena zur Rettung des preussischen Staats zu thun?
No full textWAS WAR NACH DER SCHLACHT VON JENA ZUR RETTUNG DES PREUSSISCHEN STAATS ZU THUN?
Was war nach der Schlacht von Jena zur Rettung des preussischen Staats zu thun? ([1]r)
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Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Von Gottes Gnaden Wir Johann Ernst/ Hertzog zu Sachsen/ Jülich/ Cleve und Berg ... Thun kund ... dieses unser Tax-Patent ...
No full textVON GOTTES GNADEN WIR JOHANN ERNST/ HERTZOG ZU SACHSEN/ JÜLICH/ CLEVE UND BERG ... THUN KUND ... DIESES UNSER TAX-PATENT ...
Von Gottes Gnaden Wir Johann Ernst/ Hertzog zu Sachsen/ Jülich/ Cleve und Berg ... Thun kund ... dieses unser Tax-Patent ... ([1]r
[Thun mit Blick auf Schleusenbrücke, Schloss und Aare]
No full textAnonyme/r Fotograf/inUnnummeriert. Photochrom Nr. 937 (Thun vom Thunerhof aus) ist das gleiche Bild, eventuell handelt es sich um einen ProbedruckDatierung gemäss Dokumentation der Firma Photoglob AG, 201
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Weight reduction and bone loss in postmenopausal women: follow up at 2 years
No full textShort-term weight loss (WL) is accompanied by bone loss in postmenopausal women, but the longer-term impact is unclear. The goal of this study was to determine whether weight regain compared to maintenance of WL in reduced obese/overweight women has an impact on bone mineral density (BMD) and content (BMC). It was hypothesized that weight regain in reduced obese women would result in partial recovery of bone, as compared to women who maintain their lost weight. We measured hip, spine, forearm, and total body BMD and BMC by dual energy x-ray absorptiometry. Hormones, markers of bone turnover, and soft tissue were assessed. We recruited postmenopausal women (n=40, BMI of 28.2 +/- 2.9 kg/m2; 60.6 +/- 5.6 years) 1.5 years after a 6 month weight loss program who were categorized as regaining (>75%) or maintaining their weight lost. After 6 mo of WL, both groups lost -9.1 +/- 3.1% body weight with no significant difference between groups. At 23 +/- 6 mo after baseline, the weight-loss maintainers (WL-M, n=22) and weight-loss re-gainers (WL-R, n=18) lost -10.4 +/- 4.3 % and -2.6 +/- 3.6 % of their body weight. Participants averaged 1228 +/- 529 mg/d during the follow-up period, which did not differ significantly between the groups. The WL-M group showed greater BMD loss at the trochanter (p0.422, p<0.01), but not trunk fat, suggesting that regional fat tissue may have a differential influence on bone. These data in postmenopausal women show that bone continues to decline at the trochanter and femoral neck over a 2 year period with 10% weight loss, and with weight regain there is partial recovery of bone.M.S.Includes bibliographical references (p. 42-49)by Nancy L. von Thu
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