1,721,090 research outputs found
Changes in protein, carbohydrate, and fat metabolism with aging: possible role of insulin
No full text
Response to comment on: Tessari et al. Roles of insulin, age, and asymmetric dimethylarginine on nitric oxide synthesis in vivo. Diabetes 2013;62:2699-2708
Full text linkOurs as well as other recently published
articles challenge the somehow dogmatic concept
about the existence of a uniform and comprehensive
state of “insulin resistance,” a condition that should be
considered multifaceted, and not defined just on the basis
of the reduced insulin-mediated glucose disposal. This
more complex view may have relevant consequences
not only from a mechanistic but also from a therapeutic
standpoint
Interorgan amino acid exchange
No full textThis review is concerned with the status of our current research related to the exchange of amino acids across organs. Accumulation of knowledge regarding how amino acid pools are maintained within the body remains a work in progress. In recent years, the use of organ balance measurement techniques in combination with isotopic tracers has much increased our understanding of the role of the kidney and splanchnic organs in amino acid metabolism, and in kidney and liver gluconeogenesis from amino acids. An interorgan cooperation between the kidney and splanchnic organs for leucine-ketoisocaproate metabolism has also been demonstrated
Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver
No full textMetformin has been proposed as a potential drug treatment to reduce liver steatosis. Therefore, the study of the effects of in vivo metformin administration, on hepatic fat metabolism in the isolated perfused liver is of great interest. We have studied the effects of in vivo metformin treatment of rats with experimentally induced overweight, hyperglycemia and hypertriglyceridemia, on plasma hormone and metabolite concentrations, as well as on triglyceride and ketone body output by the isolated perfused livers. Sprague-Dawley rats were fed ad libitum with a high lipid diet for 10 weeks. Then, one rat group was treated for 7 days with 350 microg/kg of BW of metformin per day, whereas the control group received only water. Thereafter, the livers were excised and perfused in vitro under controlled conditions. The hypertriglyceridemic rats had a greater body weight, as well as greater plasma glucose, insulin and triglyceride concentrations, than the control rats fed ordinary chow. In vivo metformin treatment decreased plasma glucose, insulin and triglyceride concentrations. With respect to the overweight, hyperglycemic, hypertriglyceridemic, untreated control rats, the cumulative (i.e. over 3 h of perfusion) triglyceride output by the perfused livers was decreased by >60%, whereas total ketone body (i.e. the sum of 3-hydroxybutyrate and acetoacetate) output was increased by >100% (p < 0.01 for both). In conclusion, the in vivo treatment with metformin of rats with diet-induced overweight and hypertriglyceridemia is capable to re-address hepatic fatty acid metabolism from lipogenesis toward fat oxidation and ketone body production, either directly or through a reduction of insulin concentration
PANE E DIABETE: UN POSSIBILE SEMAFORO VERDE
Full text linkanche il pane, grande protagonista della dieta mediterranea,
può contribuire al controllo metabolico del diabete di tipo 2 purché sia formulato con
ingredienti naturali, ma dosati in modo opportuno per garantire una standardizzazione del
prodotto, facilmente utilizzabile anche a livello domestico
- …
