1,720,995 research outputs found
Trends in Stem Cell Proliferation and Cancer Research: BH3-only proteins in cancer and apoptosis
No full textApoptosis of squamous cells at different stages of carcinogenesis following 4-HPR treatment
No full textCD85/LIR-1/ILT2 and CD152 (cytotoxic T lymphocyte antigen 4) inhibitory molecules down-regulate the cytolytic activity of human CD4+ T-cell clones specific for Mycobacterium tuberculosis
No full textInhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes
No full textClass switching consists in the substitution of the heavy-chain constant region of immunoglobulin M (IgM)
with that of IgG, IgA, or IgE. This enables antibodies to acquire new effector functions that are crucial to
combat invading pathogens. Class switching usually requires engagement of CD40 on B cells by CD40 ligand
(CD40L) on antigen-activated CD4 T cells and the production of cytokines. The process must be regulated
tightly because abnormal IgG and IgA production favors the onset of autoimmunity, whereas increased
switching to IgE leads to atopy. These inflammatory disorders can be triggered or exacerbated by costimulatory
signals. Although thoroughly investigated on T cells, the roles of the inhibitory receptors CD85j, LAIR-1, and
CD152 on B-cell functions have not been fully elucidated. In this study we show that cross-linking of the B-cell
inhibitory receptors by specific monoclonal antibodies inhibits IgG and IgE production, reduces the percentage
of IgG- and IgE-expressing B cells, and down-regulates interleukin 8 (IL-8), IL-10, and tumor necrosis factor
alpha production. These effects were demonstrated using different B-cell stimulatory pathways (recall antigens,
CD40L-transfected cells plus IL-4, and lipopolysaccharide plus IL-4). It thus appears that CD85j, LAIR-1, and
CD152 play a central role for the control of IL-4-driven isotype switching
Inhibitory receptors CD85j, LAIR-1 and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes
No full text
CTLA-4 inhibits the specific lysis mediated by human cytolytic T lymphocytes in a clonal distribute fashion.
No full textThe inhibitory function of CD85/LIR-1/ILT2 is exerted on actively proliferating T cells via apoptosis.
No full textEffects of CCl4 poisoning on metabolism of dolichol in rat liver microsomes and Golgi apparatus.
No full text- …
