1,721,192 research outputs found
Fatigue in multiple sclerosis: Does the functional or structural damage prevail?
No full textFatigue in multiple sclerosis (MS) is a highly invalidating symptom, lacking efficacious drugs. This topical review aims at assessing the signs in the literature of functional versus structural damage prevalence at the origin of MS fatigue by focusing on papers that assessed the two counterparts in the same patients, paying attention that the fatigue levels do not correlate with clinical severity. We summarize and discuss evidence of increased levels of fatigue occurring together with the alterations of functional connectivity at multiple levels, in the absence of any relationship with lesion load and local atrophy of the involved structures. Specifically, neuronal communication mainly altered in the corticomuscular synchronizations, between hemispheric homologs and in the resting-state networks involved in emotion (cingulate cortex) and effort-reward balance (striatum and inferior parietal lobule). Finally, given the functional prevalence in neuronal network alterations at the origin of fatigue in MS, we highlight the relevance of developing treatments aiming at compensating the neuronal electric communication dysfunctions
Molecular mechanisms underlying copper function and toxicity in neurons and their possible therapeutic exploitation for Alzheimer's disease
No full textOxidative stress and brain glutamate-mediated excitability in depressed patients
No full textBackground: Several neuropsychiatric pathologies have been recently linked to oxidative stress. In this study, we investigated the relationship between depression, markers of oxidative stress and neurotransmission, as expressed by sensory cortex excitability. Methods: Serum levels of oxidative stress markers and somatosensory magnetic fields, evoked by external galvanic stimulation, were measured in 13 depressed patients and 13 controls. Results: Depressives had higher levels of total and free copper than controls and lower levels of transferrin. They also showed lower sensory cortex excitability, which correlated with copper levels in controls, but not in patients. Transferrin correlated with sensory cortex excitability in both patients and controls, although in opposite ways. Copper level results associated with the patients' clinical status. Limitations: Small sample size and possible sampling bias in patient selection. Conclusions: Pro-oxidant agents appear to affect neuronal excitability and clinical state of depressed patients, as free copper excess alters their cortical glutamatergic neurotransmission. (C) 2010 Elsevier B.V. All rights reserved
Choice of multivariate autoregressive model order affecting real network functional connectivity estimate
No full textOBJECTIVE: A realistic simulation exploiting real cortical sources identified from non-invasive extra-cranial recordings in healthy subjects has been considered in order to select the most robust procedure for choosing the correct order of multivariate autoregressive (MVAR) models. Different signal-to-noise ratios filter settings and sampling rates were also tested on the estimate of functional connectivity among the network nodes, in simulated and real cases. METHODS: Starting from magnetoencephalographic recordings, cortical sources in primary sensorimotor areas of the hand were obtained by functional source separation (FSS). Different criteria for the choice of the model order were compared in the simulated network constructed through one of the FSS-extracted sources and its noise-added delayed copies. In two real cases, a validation of the model order (not known a priori) choice was obtained by comparing the time-frequency properties as depicted by classical non-parametric and MVAR methods at rest, during isometric contraction (stationary states) and while dynamically responding to a sensory stimulation (transient state). For completeness, the whole set of MVAR functional connectivity measures was taken into account, to assess the most suitable for our network description. RESULTS: That the use of an incorrect model order distorts network functional connectivity estimate was documented both in the realistic simulation and in the two real cases. The Minimal Description Length and Schwartz Bayesian Criterion were selected as the most robust for MVAR model order choice. Partial directed coherence (PDC) was the most suitable method for time-frequency connectivity estimate in the simulated as well as in the real cases, both in stationary and transient states. Moreover, the results of MVAR-based connectivity estimate depend on filter setting in the real case. CONCLUSIONS: The most robust procedure for choosing the correct MVAR model order was provided. The adjunctive comparison of MVAR to classical methods is recommended to validate the choice in the real case. SIGNIFICANCE: Correct MVAR model order choice and band filtering play an important role for the correct network connectivity estimate
Neural connettivity in hand sensorimotor area: an evaluation by evoked fields morphology
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Optimization of an Independent Component Analysis approach for artifact identification and removal in MEG signals
No full textAcute Phase Neuronal Activity for the Prognosis of Stroke Recovery
Full text linkStrokes causing similar lesions and clinical states can be followed by diverse regains of neurological functions, indicating that the clinical recovery can depend on individual modulating factors. A promising line to disclose these factors, to finally open new therapeutic strategies, is to search for individual indices of recovery prognosis. Here, we pursued on strengthening the value of acute phase electrophysiological biomarkers for poststroke functional recovery in a wide group of patients. We enrolled 120 patients affected by a monohemispheric stroke within the middle cerebral artery territory (70 left and 50 right damages) and collected the NIH stroke scale (NIHSS) score in the acute phase (T0, median 4 days) and chronic follow-up (T1, median 6 months). At T0, we executed electrophysiological noninvasive assessment (19-channel electroencephalography (EEG) or 28 channels per side magnetoencephalography (MEG)) of brain activity at rest by means of band powers in the contra- and ipsilesional hemispheres (CLH, ILH) or the homologous area symmetry (HArS). Low-band (2-6 Hz) HArS entered the regression model for predicting the stabilized clinical state (p<0.001), with bilateral impairment correlated with a poor outcome. Present data strengthen the fact that low-band impairment of homologous ipsi- and contralesional hemispheric regions in the acute stroke indicate a negative prognosis of clinical recovery
Functional localization of the sensory hand area with respect to the motor central gyrus knob
No full textThe aim of this work was to investigate the topography of the primary sensory hand cortex with magnetoencephalography in order to define the functional anatomy of this area in healthy humans. Previous studies denoted an inverted Ohm or an horizontal epsilon shaped knob on the pre-central gyrus as a landmark for the motor hand area; therefore a systematic difference between the orientation of the source for thumb with respect to little finger should be observed. We found this systematic difference, but the direction of the sources activated during thumb and little finger stimulation did not converge, as would be expected if only the Ohm convexity is activated: in fact our results suggest that thumb sensory area also extends to the area lateral to this convexity
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