1,944 research outputs found
Advanced hepatitis C virus replication PDE models within a realistic intracellular geometric environment
No full textThe hepatitis C virus (HCV) RNA replication cycle is a dynamic intracellular process occurring in three-dimensional space (3D), which is difficult both to capture experimentally and to visualize conceptually. HCV-generated replication factories are housed within virus-induced intracellular structures termed membranous webs (MW), which are derived from the Endoplasmatic Reticulum (ER). Recently, we published 3D spatiotemporal resolved diffusion–reaction models of the HCV RNA replication cycle by means of surface partial differential equation (sPDE) descriptions. We distinguished between the basic components of the HCV RNA replication cycle, namely HCV RNA, non-structural viral proteins (NSPs), and a host factor. In particular, we evaluated the sPDE models upon realistic reconstructed intracellular compartments (ER/MW). In this paper, we propose a significant extension of the model based upon two additional parameters: different aggregate states of HCV RNA and NSPs, and population dynamics inspired diffusion and reaction coefficients instead of multilinear ones. The combination of both aspects enables realistic modeling of viral replication at all scales. Specifically, we describe a replication complex state consisting of HCV RNA together with a defined amount of NSPs. As a result of the combination of spatial resolution and different aggregate states, the new model mimics a cis requirement for HCV RNA replication. We used heuristic parameters for our simulations, which were run only on a subsection of the ER. Nevertheless, this was sufficient to allow the fitting of core aspects of virus reproduction, at least qualitatively. Our findings should help stimulate new model approaches and experimental directions for virology
Impact of future HERA data on the proton PDF uncertainties using the ZEUS NLO QCD fit
No full textThe high precision and large kinematic coverage of the data from the HERA-1 running period (1994-2000) have already allowed precise extractions of proton parton distribution functions. The HERA-II program is now underway and is expected to provide a substantial increase in the luminosity collected at HERA. In this paper, the first estimate of the impact of future data from HERA, on the proton PDF uncertainties, is presented. Next-to-leading order QCD predictions for inclusive jet cross sections at the LHC are presented using the projected PDFs
Lipid metabolism and HCV infection
No full textChronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV
Classical and C-motivic Adams charts
No full textThis repository contains large-format Adams charts that compute 2-complete stable homotopy groups, both in the classical context and in the C-motivic context. The charts are essentially complete through the 90-stem and contain partial results to the 110-stem.
Also included are the data files, in csv format, that generate the charts. See the README file for a description of the data files.The first author was supported by NSF grants DMS-1606290 and DMS-1904241. The second author was supported by grant NSFC-11801082. The third author was supported by NSF grants DMS-1810638 and DMS-2043485. Many of the associated machine computations were performed on the Wayne State University Grid high performance computing cluster
The works of John Adams : second president of the United States: with a life of the author, notes and illustrations /
No full text"Three hundred copies printed on large paper"--Sabin, Bibl. amer., v. 1, no. 253.Some volumes have spine title: Life and works of John Adams.Vol. 2-6 have imprint: Boston, C. C. Little and J. Brown.I. Life of John Adams. [By C. F. Adams] -- II. Diary, with passages from an autobiography. Notes of debates in the Continental congress in 1775 and 1776. Autobiography -- III. Autobiography (cont.) Diary. Notes of a debate in the Senate of the United States. Essays: On private revenge. On self-delusion. On private revenge. Dissertation on the canon and the feudal law. Instructions of the town of Braintree to their representative, 1765. The Earl of Clarendon to William Pym. Governor Winthrop to Governor Bradford. Instructions of the town of Boston to their representatives, 1768. Instructions of the town of Boston to their representatives, 1769. On the independence of the judiciary: a controversy between W. Brattle and J. Adams, 1773 -- IV. Novanglus; or, A history of the dispute with America, from its origin, in 1754, to the present time. Letter to Richard Henry Lee, 15 November, 1775. Thoughts on government, applicable to the present state of the American colonies. Letter to John Penn, January, 1776. Report of a constitution or form of government for the commonwealth of Massachusetts, 1779. Defence of the constitutions of government of the United States of America, against the attack of M. Turgot, in his letter to Dr. Price, 22 March, 1778. vol. I -- V. Defence of the constitutions ... vol II-III -- VI. Defence of the constitutions ... vol. III, cont. Discourses on Davila, a series of papers on political history. Four letters, being an interesting correspondence between John Adams and Samuel Adams, on government. Three letters to Roger Sherman on the Constitution of the United States. Roger Sherman to John Adams in reply. Letters to John Taylor, of Caroline, Virginia, in reply to his strictures on some parts of the Defence of the American constitutions. Review of the propositions for amending the Constitution, submitted ... in 1808 -- VII-VIII. Official letters, messages, and public papers, 1777-1799 -- IX. Official letters, messages, and public papers, 1797-1801. Correspondence originally published in the Boston patriot. Genral correspondence, 1770-1811 -- X. General correspondence, 1811-1825. Indexes.Microform.Microform.Mode of access: Internet
The works of John Adams, second President of the United States: with a life of the author, notes and illustrations,
No full textVol. 6 has imprint: Boston, C. C. Little and J. Brown, 1861.(Cont) v. 5. Defence of the constitutions ... vol. II-III.--v. 6. Defence of the constitutions ... vol. III, cont. Discourses on Davila, a series of papers on political history. Four letters, being an interesting correspondence between John Adams and Samuel Adams, on government. Three letters to Roger Sherman on the Constitution of the United States. Roger Sherman to John Adams, in reply. Letters to John Taylor, of Caroline, Virginia, in reply to his strictures on some parts of the Defence of the American constitutions. Review of the propositions for amending the Constitution, submitted ... in 1808.--v. 7-8. Official letters, messages, and public papers, 1777-1799.--v. 9. Official letters, messages, and public papers, 1797-1801. Correspondence originally published in the Boston Patriot. General correspondence, 1770-1811.--v. 10. General correspondence, 1811-1825. Indexes.(Cont) v. 4. Novanglus; or, A history of the dispute with America, from its origin, in 1754, to the present time. Letter to Richard Henry Lee, 15 November, 1775. Thoughts on government, applicable to the present state of the American colonies. Letter to John Penn, January, 1776. Report of a constitution or form of government for the commonwealth of Massachusetts, 1779. Defence of the constitutions of government of the United States of America, against the attack of M. Turgot, in his letter to Dr. Price, 22 March, 1778. vol. I.--v. 1. Life of John Adams. [By C. F. Adams]--v. 2. Diary, with passages from an autobiography. Notes of debates in the Continental Congress, in 1775 and 1776. Autobiography.--v. 3. Autobiography (cont.) Diary. Notes of a debate in the Senate of the United States. Essays: On private revenge. On self-delusion. On private revenge. Dissertation on the canon and the feudal law. Instructions of the town of Braintree to their representative, 1765. The Earl of Clarendon to William Pym. Governor Winthrop to Governor Bradford. Instructions of the town of Boston to their representatives, 1768. Instructions of the town of Boston to their representatives, 1769. On the independence of the judiciary: a controversy between W. Brattle and J. Adams, 1773.--Mode of access: Internet
A Case of Identity: John Adams and Massachusettensis
No full textThis article undertakes an interdisciplinary reexamination of the claims of American revolutionary John Adams (1735–1826) that Jonathan Sewall (1729–96) was a lead author of the influential Loyalist tracts Massachusettensis (Dec. 12, 1774–April 3, 1775). The Massachusettensis letters constitute the most cogent articulation of Loyalist ideology on the eve of the American Revolution. Adams replied with his Novanglus letters (Jan. 23–April 17, 1775). While Adams believed that Sewall was the author or coauthor of Massachusettensis, scholars subsequently attributed sole authorship to Daniel Leonard (1740–1829), a Loyalist refugee who claimed authorship whilst in exile in England. After reviewing the historical and literary evidence and the results of authorship attribution tests, we proffer four historiographical conclusions. First, Massachusettensis was probably coauthored by Leonard and Sewall with Sewall exercising editorial direction over this and other Loyalist propaganda. This validates Adams’s contention that Sewall had a principal role in Massachusettensis’s composition. Second, Adams’s presumption of Sewall’s authorship shaped the writing of both Massachusettensis and Novanglus, as revealed in a critical reading of the debate. Third, Adams biographers and Revolution scholars have underestimated the extent to which the literary contest with “Massachusettensis” was instrumental in John Adams’s radicalization. Fourth, the Novanglus-Massachusettensis debate was shrouded in friendship: publicly it encapsulated the signal ideological differences between Patriots and Loyalists while privately crowning a friendly rivalry between Adams and Sewall of fifteen years’ standing. Their friendship may have facilitated communication between British headquarters and the American rebels in the weeks preceding the outbreak of military hostilities. In sum, this article demonstrates the vitality of friendship as an analytical category for political history. Friendship has been under studied by historians of the American Revolutionary Era but the Revolution was at its most revolutionary in the division of intimate friends like Adams and Sewall
Dijet Photoproduction and the Structure of the Proton with the ZEUS Detector.
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
3D spatially resolved models of the intracellular dynamics of the Hepatitis C genome replication cycle
No full textMathematical models of virus dynamics have not previously acknowledged spatial resolution at the intracellular level despite substantial arguments that favor the consideration of intracellular spatial dependence. The replication of the hepatitis C virus (HCV) viral RNA (vRNA) occurs within special replication complexes formed from membranes derived from endoplasmatic reticulum (ER). These regions, termed membranous webs, are generated primarily through specific interactions between nonstructural virus-encoded proteins (NSPs) and host cellular factors. The NSPs are responsible for the replication of the vRNA and their movement is restricted to the ER surface. Therefore, in this study we developed fully spatio-temporal resolved models of the vRNA replication cycle of HCV. Our simulations are performed upon realistic reconstructed cell structures—namely the ER surface and the membranous webs—based on data derived from immunostained cells replicating HCV vRNA. We visualized 3D simulations that reproduced dynamics resulting from interplay of the different components of our models (vRNA, NSPs, and a host factor), and we present an evaluation of the concentrations for the components within different regions of the cell. Thus far, our model is restricted to an internal portion of a hepatocyte and is qualitative more than quantitative. For a quantitative adaption to complete cells, various additional parameters will have to be determined through further in vitro cell biology experiments, which can be stimulated by the results deccribed in the present study
Family Assessment- Author Index
No full textAuthor Index (12 pages)
A-Z
A
Abbott, D.: 263 Abery, B.: 242 Abidin, R: 81, 265 Abramovitch, R: 134, 135, 136, 137, 139,142,143,144,145,146 Abril, s.: 118 Achenbach, T. M.: 12,47, 118, 223, 265 Acock, A. c.: 206 Adams, G. R: 205 Adams, S. J.: 226 Al-Khayyal, M.: 74 Alexander, J. F.: 75 Allisson, P. D.: 185 Alwin, D. F.: 182,191,194 Amato, P. R: 205- 231, 206, 207, 210, 213,215,216, 219, 221, 222, 224, 227,230 Ammerman, R : 263 Amoloza, T. 0 .: 170, 171,172,176, 179, 187, 188 Anastasi, A.: 265 Anderson, B. J.: 85 Anderson, c.: 117 Anderson, P. P.: 104 Anderson, S. A.: 79, 168, 177 Anthony, J.: 117 Apley, J.: 84 Aponte, H. J.: 117 Appelbaum, M.: 263 Arrington, A.: 11 Asher, S.: 82 Asterita, M. F. : 92 Attneave, c.: 121 Auslander, W. F: 85
Z
Zane, N .: 107, 119 Zetlin, A.: 263 Zill, N.: 83 Zuo, J.: 171, 180, 18
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