1,721,063 research outputs found
The human genome project and the discovery of genetic determinants of cancer susceptibility
No full textThe Human Genome Project has recently provided a great deal of information on the sequence that comprises the human genome. We are now in the process of structuring and deciphering the 3 × 109 base sequence in order to gain insights into its functional role. Several efforts are focusing on the search for DNA sequence variations underlying common/complex diseases that constitute a real burden in terms of public health measures. As expected, the genetic architecture of these complex traits, shows tremendous complexity, and the discovery and characterisation of susceptibility alleles constitute a real challenge for the geneticist. Conceptual and experimental genetic approaches aimed at dissecting the molecular features of susceptibility genes, in particular those predisposing to cancer, are outlined and discussed in this reveiw
Are Tumor Suppressor Genes Playing a Role in the Deregulation of Tissue Organization in Cancer?
No full textA TaqI polymorphism in a gene belongingto the human apoprotein(a)-plasminogen gene family on the telomeric region ofchromosome 6 (6q26-27)
No full text
Mammalian Rh/T2/S-glycoprotein ribonuclease family genes:cloning of a human member located in a region of chromosome 6q27 frequently deleted in human malignancies
No full textSeveral liver specific DNAse hypersensitive sites are present in the intergenic region separating human plasminogen and apoprotein(A) genes
No full textNucleotide sequence of thecDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat.
No full textA new constitutivelyactivating mutation of the Gs protein alpha subunit-gsp oncogene is found inhuman pituitary tumours
No full text
- …
