155,474 research outputs found
Illustra il genere. un concorso per vignette sul linguaggio di genere all’Università di Genova
No full textGli esiti di un concorso di vignette sul tema del linguaggio di genere promosso dall’Università di Genova
Treatment of hepatitis C virus genotype 4 in the DAA era
No full textAbstract The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA’s. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a ‘field-practice’ scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir
EDI Plan di dipartimento, Project Gender Action Plan e Syllabus inclusivo: azioni pilota per attuare la dimensione di genere+ in accademia
No full textIl contributo esamina gli sforzi dell’Unione Europea a partire dal 2000 per promuovere la parità di genere nel settore scientifico e illustra tre azioni pilota volte a consolidare gli obiettivi richiesti da Horizon Europe riguardo all’integrazione della dimensione di genere+ nella ricerca e nei programmi di insegnamento.
Nel 2000, il gruppo di lavoro su Donne e Scienza dell’European Technology Assessment Network ha evidenziato le discriminazioni contro le donne e i gruppi sottorappresentati, chiedendo un miglioramento che implichi una trasformazione globale della scienza e delle istituzioni. Circa 20 anni dopo, la Dichiarazione di Lubiana sulla Parità di Genere nella Ricerca e Innovazione (2021) si impegna ad affrontare le sfide della transizione digitale
ed ecologica in modo equo e inclusivo. Tuttavia, persistono ancora disuguaglianze, come dimostrano i rapporti di LERU (2019), ERA e She Figures (2021), che rivelano una discrepanza tra le politiche dell’UE e nazionali e la loro attuazione.
L’Università di Genova sta implementando nel suo Piano per la Parità di Genere tre Azioni Pilota Innovative: EDI Plan di Dipartimento, Project Gender Action Plan e Syllabus Inclusivo.
Si tratta di iniziative facilmente implementabili, in quanto basate su un approccio bottom-up in cui gli attori coinvolti hanno il potere decisionale e operativo di agire senza vincoli organizzativi, strutturali o legislativi
Hepatitis C virus direct acting antivirals impact on renal function in the first 4 weeks of treatment
No full textLife Cycle Assessment for eco-design of product–package systems in the food industry—The case of legumes
No full textAgri-food sector highly contributes to the consumption of water and energy resources and presents significant environmental impacts that can be comprehensively evaluated through a Life Cycle Assessment (LCA). This paper investigates the environmental sustainability of a set of legumes (i.e. peas, beans and chickpeas) manufactured in Italy by a Group representing one of largest agri-food European companies, thus allowing to drive eco-design measures for the productâpackage system. Such products are packaged in glass bottles or in steel tin cans and sold as singles or in multipacks. A deep process analysis was performed through a LCA approach in order to identify environmental hot-spots in the whole life-cycle. The results are expressed through a set of impact categories, which can be read also as stand-alone indicators, identified in order to pave the way for waterâenergyâfood nexus quantification: global warming potential, non-renewable cumulative energy demand, water scarcity index and toxicity potentials. Direct inventory data were collected from the involved farms and the production plants along the whole supply chain. Packaging production and crop cultivation have proven to be the most relevant subsystems for all the studied products and impact categories. In particular, the production of packaging is the major hot-spot accounting for over 70% of the total global impacts, for all the legumes under study. Only the water use impact category presents a peculiar pattern depending on the examined product. On the basis of these findings, different packaging options were compared according to eco-design principles by means of LCA methodology. Change of material, various format options and different recycling rates were investigated to quantify the relevant achievable benefits. Moreover, the variation of crop yields and fertilizers rates was studied to assess the importance of these parameters in the whole life-cycle
HCV elimination plan leads to significant benefits in managing liver-related diseases and hospital interventions : a regional simulation
No full textObjectives: This article presents a 3-year budget impact simulation on the effects of a chronic Hepatitis C (HCV) eradication plan in real-life costs incurred by the Regional Health Service. Methods: The Liguria Region network performed a prospective 3-year (2017–2019) timeframe horizon trends simulation analysis focusing on management interventions and costs. It involved all the eight prescribing centers in the region, starting from retrospective historical performance data and assuming the impact of sustained viral response rates for patients treated for HCV. Data on hospital admissions, medical visits, number of patients, and deaths were collected through the healthcare database. Results: At the beginning of 2017, 2,940 patients were eligible for HCV treatment with direct-acting antivirals. Assuming to treat this entire population with a success rate of 90%, the events related to liver complications in the horizon would decrease to 5,538 cumulatively (−35%), with a 27% reduction of direct costs, showing a global savings of 24,779.024 Euros. Conclusion: Treating the entire eligible HCV population would lead to significant benefits and savings in managing liver-related diseases and their direct costs, opening opportunities to re-think new settings for the future organization of liver disease management in the regional health system
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