1,722,268 research outputs found
Tamassia, Nino
No full textNino Tamassia, giurista, professore di storia del diritto italiano, senatore, XIX-XX secol
Tamassia, Arrigo
No full textVoce biografica dedicata allo scienziato e medico Arrigo Tamassia, con particolare riguardo al suo impegno nel campo della psichiatria
René Char, le Logos d’Héraclite et les impasses de l’avant-garde
No full textTamassia Paolo. René Char, le Logos d’Héraclite et les impasses de l’avant-garde. In: Littératures 42, printemps 2000. pp. 127-142
Recensione a P. Tamassia, Sartre e il Novecento
No full textRecensione al volume di Paolo Tamassia, che indaga l'influenza di Sartre nel pensiero filosofico del NOvecent
Alain Nadaud et Paolo Tamassia
No full textpaolo tamassia J’ai le plaisir de présenter Alain Nadaud. Juste quelques mots pour dire que dans sa vie il a entrepris plusieurs activités qui l’ont amené à parcourir le monde. Il a enseigné la littérature à l’étranger, en Mauritanie, en Iraq ; il a été conseiller pédagogique pour l’enseignement du français au Nigéria. Par la suite, il a travaillé comme conseiller littéraire auprès de différentes maisons d’édition : Denoël, Ramsay, Balland, Belfond. Puis il est à nouveau parti à l’étranger, d..
Paolo Tamassia, Sartre e il Novecento
Full text linkIl saggio di Paolo Tamassia Sartre e il Novecento si presenta come una ricca e approfondita ricognizione dei rapporti che l’opera di Sartre intrattiene con il pensiero dei maggiori intellettuali del Novecento, da Bataille a Foucault, da Nancy a Spanos e a Lyotard fra gli altri. L’A. dimostra quanto la speculazione sartriana, lungi dall’essere ingabbiata unicamente nella teoria dell’engagement, sia in realtà poliedrica e sempre in fieri, aperta al confronto con le sollecitazioni di natura lett..
La rappresentazione del lavoro nella prosa breve in Germania e Francia (1980-2020): Introduzione
No full textQuesto articolo introduce la sezione monografica La rappresentazione del lavoro nella prosa breve in Germania e Francia (1980-2020) curata da Massimiliano De Villa e Paolo Tamassia
Understanding why LPS is unable to mobilize the MyD88-independent pathway in human neutrophils
No full textBackground: Lipopolysaccharide (LPS) activates both MyD88-dependent and -independent signaling via TLR4, but the extent to which each cascade is operative in different cell types remains unclear. Materials and methods: Human neutrophils and monocytes, isolated from buffy coat, were stimulated with LPS and then disrupted in a nitrogen bomb to prepare protein extracts with preserved integrity and association. Lysates were then subjected to WB, immunoprecipitation or co-immunoprecipitation using specific antibodies raised against TBK1, TRIF, TRAF3,NAP1, HSP-90 and SHP-2. Results: In a previous study (Tamassia N. et al., J Immunol.2007; 178(11):7344-56), we have demonstrated that human neutrophils are unable to mobilize the MyD88-independent path-way, as revealed by the lack of inducibility neither of IFNb(the principal MyD88-independent gene) nor of IFNb-dependent genes in LPS-treated cells. Consistent with these latter results, we have also found that IRF3, a critical transcription factor for IFNb gene induction, and TBK1, an IRF3-phosphory-lating kinase, are both not activated by LPS in human neutrophils. We are currently investigating the molecular mechanisms that, ultimately, may explain why in neutrophils the TLR4-mediated, MyD88-independent pathway is impaired. Specifically, we are testing whether the interactions of TBK1with its various regulatory proteins, such as TRIF, TRAF3,NAP1, HSP-90 and SHP-2, appropriately occur or not inhuman neutrophils. Conclusions: Our results will elucidate the molecular bases of the disconnected activation of the signaling pathways down-stream of TLR4 in key cellular components of the inflammatory and immune responses. They will also help to better understand the primordial role of neutrophils in host defence against non-viral infections
Molecular bases of TLR4 induced gene expression in human neutrophils
No full textNon disponibileNeutrophils play an essential role in infection and innate immunity, providing early
defense against invading microorganisms. They comprise approximately two-thirds of
peripheral blood leukocytes and transit rapidly to sites of infection, where they limit infection
and allow recruitment and activation of other immune cells through the release of
inflammatory mediators and antimicrobial products, resulting in pathogen clearance and
ultimately, in the initiation of an adaptive immune response (1). Excessive or inappropriate
neutrophil activation can result in dysregulated inflammation and severe tissue damage and
thus contributes to the pathology of a variety of noninfectious diseases, such as rheumatoid
arthritis, inflammatory bowel disease, asthma, chronic obstructive pulmonary disease, and
acute respiratory distress syndrome (2, 3).
Mature granulocytes originate (at a rate of 80 millions per minute) from pluripotential
stem cells located in the bone marrow, under the influence of several growth factors named
colony-stimulating factors (CSFs), which include multi-CSF (also known as Interleukin-3),
Granulocyte and Macrophage CSF (GM-CSF), Granulocyte CSF (G-CSF), and Macrophage
CSF (M-CSF) (4) (5). Neutrophils are members of the granulocyte family of leukocytes,
which also comprises eosinophils (< 1.5 %) and basophils (<0.5 %). A1l three cell types
contain distinct cytoplasmic granules, which are storage pools for intracellular enzymes,
cationic proteins, receptors and other proteins.
Within the circulation, neutrophils exist in two pools which are in a dynamic
equilibrium: a circulating pool, and a ''marginated'' pool; the latter is believed to be
4
sequestered within the microvasculature of many organs. Under pathological conditions, such
as bacterial infections, the number of circulating neutrophils may increase dramatically (even
up to ten-fold), as a result of an accelerated release of neutrophils from the bone marrow,
combined with a stimulated maturation of immature neutrophils by CSFs and demargination
from the lungs or the spleen. Cell-labeling experiments have shown that the lifespan of
neutrophils in the circulation, compared to the ones of other cell types such as
monocytes/macrophages which may live for months or even years, is short, with a half-life of
approximately 7 hours. Senescent neutrophils are thought to undergo apoptosis prior to
removal by macrophages (6). This process may also play a role in terminating inflammatory
responses, and its importance can be illustrated by the fact that PMN disintegration in vivo
would cause the release of their cytotoxic content into the extracellular milieu and thus
inflammation..
La “polemica bizantina” tra Giovanni Tamassia e Francesco Schupfer
No full textLa ricerca ha ad oggetto la celebre querelle sulle origini del diritto medievale italiano. Tale dibattito ha avuto luogo a partire dalla recensione di Francesco Schupfer del 1888 sul contributo di Giovanni Tamassia, pubblicato nel primo fascicolo del vol. XL dell’Archivio Giuridico, con il titolo Bologna e le Scuole Imperiali di diritto. A tale recensione fece seguito, nel quarto fascicolo dello stesso volume dell’Archivio Giuridico, la risposta di Tamassia, a cui Schupfer reagì, sempre nel 1880, con una ulteriore nota critica. Sì è messo in luce come tale dibattito scientifico, denominato “polemica bizantina” dallo stesso Schupfer, se è vero che ebbe origine in Italia, così come italiani furono per la gran parte i suoi interpreti, è altrettanto vero che si collocò nel mutato clima degli orientamenti dottrinari della cultura giuridica europea
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