117,417 research outputs found
Tam-inducible MHCII expression models recapitulate WT and B-cell mediated adoptive transfer EAE models.
No full text(A) Mean ± SEM EAE scores recorded for CD20-BMHCIIxIgHMOG (blue circles), and UBCMHCII (red squares) mice treated with Tam by oral gavage and WT (black squares), CD19-BMHCIIxIgHMOG (grey circles), treated with corn oil vehicle by oral gavage once, three days prior to receiving 5x106 encephalitogenic CD4 T cells. Data is representative of three independent experiments with n = 3–5 mice per genotype. (B) Day of EAE onset post cell transfer for WT (black squares), UBCMHCII (red squares), CD19-BMHCIIxIgHMOG (grey circles) treated with corn oil 72 hours prior to CD4 T cell transfer and CD20-BMHCIIxIgHMOG (blue circles) recipient mice treated with Tam 72 hours prior to CD4 T cell transfer. Graph shows mean day of onset ± SEM from two pooled, independent experiments with n = 2–4 mice per genotype. Unpaired t test performed to compare day of onset between WT and CD19-BMHCIIxIgHMOG mice. (C) Mice were treated with Tam 72 hours prior to CD4 T cell transfer. Time to EAE onset for WT (black) and UBCMHCII (red) mice is not significantly different by log-rank test (p = 0.107). Time to EAE onset for CD19-BMHCIIxIgHMOG (grey), and CD20-BMHCIIxIgHMOG (blue) mice is not significantly different by log-rank test (p = 0.481). Incidence curves generated from two pooled, independent experiments with n = 2–4 mice per genotype.</p
Low-cost on-chip clock jitter measurement scheme
No full textIn this paper, we present a low-cost, on-chip clock jitter digital measurement scheme for high performance microprocessors. It enables in situ jitter measurement during the test or debug phase. It provides very high measurement resolution and accuracy, despite the possible presence of power supply noise (representing a major source of clock jitter), at low area and power costs. The achieved resolution is scalable with technology node and can in principle be increased as much as desired, at low additional costs in terms of area overhead and power consumption. We show that, for the case of high performance microprocessors employing ring oscillators (ROs) to measure process parameter variations (PPVs), our jitter measurement scheme can be implemented by reusing part of such ROs, thus allowing to measure clock jitter with a very limited cost increase compared with PPV measurement only, and with no impact on parameter variation measurement resolution
TAM-ing T cells in the tumor microenvironment:implications for TAM receptor targeting
No full textThe TAM receptors—TYRO3, AXL, MERTK—are pleiotropically expressed receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) or Growth Arrest-Specific 6 (GAS6) with apoptotic phosphatidylserine activates the TAM receptors. Hence, this receptor family is essential for the efferocytosis of apoptotic material by antigen-presenting cells. In addition, TAM receptors are expressed by virtually all cells of the tumor microenvironment. They are also potent oncogenes, frequently overexpressed in cancer and involved in survival and therapy resistance. Due to their pro-oncogenic and immune-inhibitory traits, TAM receptors have emerged as promising targets for cancer therapy. Recently, TAM receptors have been described to function as costimulatory molecules on human T cells. TAM receptors’ ambivalent functions on many different cell types therefore make therapeutic targeting not straight-forward. In this review we summarize our current knowledge of the function of TAM receptors in the tumor microenvironment. We place particular focus on TAM receptors and the recently unraveled role of MERTK in activated T cells and potential consequences for anti-tumor immunity.</p
A Compression-Driven Test Access Mechanism Design Approach
No full textDriven by the industrial need for low-cost test methodologies, the academic community and the industry alike have put forth a number of efficient test data compression (TDC) methods. In addition, the need for core-based System-on-a-Chip (SoC) test led to considerable research in test access mechanism (TAM) design. While most previous work has considered TAM design and TDC independently, this work analyzes the interrelations between the two, outlining that a minimum test time solution obtained using TAM design will not necessarily correspond to a minimum test time solution when compression is applied. This is due to the dependency of some TDC methods on test bus width and care bit density, both of which are related to test time, and hence to TAM design. Therefore, this paper illustrates the importance of considering the characteristics of the compression method when performing TAM design, and it also shows how an existing TAM design method can be enhanced toward a compression-driven solution
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
sj-docx-1-tam-10.1177_17588359221130502 – Supplemental material for Reconsidering T component of cancer staging for T3/T4 non-small-cell lung cancer with additional nodule
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221130502 for Reconsidering T component of cancer staging for T3/T4 non-small-cell lung cancer with additional nodule by Fang Wang, Hang Su, Haoran E, Likun Hou, Minglei Yang, Long Xu, Jiani Gao, Mengmeng Zhao, Junqi Wu, Jiajun Deng, Xiaofeng Xie, Yifan Zhong, Yingze Li, Tingting Wang, Dong Xie, Chunyan Wu and Chang Chen in Therapeutic Advances in Medical Oncology</p
sj-docx-1-tam-10.1177_17588359221107113 – Supplemental material for Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221107113 for Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer by Valentina Hoyos, Spyridoula Vasileiou, Manik Kuvalekar, Ayumi Watanabe, Ifigeneia Tzannou, Yovana Velazquez, Matthew French-Kim, Wingchi Leung, Suhasini Lulla, Catherine Robertson, Claudette Foreman, Tao Wang, Shaun Bulsara, Natalia Lapteva, Bambi Grilley, Matthew Ellis, Charles Kent Osborne, Angela Coscio, Julie Nangia, Helen E. Heslop, Cliona M. Rooney, Juan F. Vera, Premal Lulla, Mothaffar Rimawi and Ann M. Leen in Therapeutic Advances in Medical Oncology</p
Data for: Uses of Artificial and Composite Treatments in Experimental Methods: Reconsidering the Problem of Validity and Its Implications for Stratification Research
No full textData collected from over 60,000 registered users of the mobile phone apps Survey Pro in mainland China. See the article for a fully description of the survey
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