130,968 research outputs found
La dieta dei cacciatori-raccoglitori gravettiani della Puglia: analisi isotopiche e datazioni al radiocarbonio AMS sugli inumati di Grotta Paglicci e Grotta di Santa Maria di Agnano.
No full textLa dieta dei cacciatori-raccoglitori gravettiani della Puglia: analisi isotopiche e datazioni al radiocarbonio AMS sugli inumati di Grotta Paglicci e Grotta di Santa Maria di Agnano
MA Mannino, S. Talamo, D. Coppola, E. Vacca, A. Rnchitelli, P. Boscato, M.P Richards
I recenti sviluppi nel campo dell'archeologia molecolare con sentono di eseguire ricostruzioni paleonutrizionali sempre più affidabili analizzando il collagene osseo estratto da reperti umani preistorici, apportando nuovi dati allo studio della sussistenza umana nel passato. Nell'ambito dd presente studio sono stati campionati gli inumati gravettiani di Grotta Paglicci (Rignano Garganico) e Grotta di Santa Maria di Agnano (Ostuni), oltre a reperti faunistici a questi contemporanei, al fine di eseguire analisi degli isotopi del carbonio e dell'azoto su collagene osseo. Queste analisi permettono di determinare l'ecosistema di origine della componente proteica dei cibi consumati e, specificatamente, se questi ultimi fossero in prevalenza terrestri, dulciacquicoli o marini. Inoltre, poiché la composizione isotopica dell'azoto varia in base allivello trofico di un organismo all'interno della catena alimentare, le analisi isotopiche forniscono anche utili indicazioni sull'importanza del consumo carneo. L'estrazione di collagene ben preservato è stata portata a termine con successo nel caso di tutti gli inumati in questione e la datazione al radiocarbonio AMS degli estratti ha confermato la loro attribuzione crono-stratigrafica al gravettiano. Nel complesso le analisi degli isotopi del carbonio e dell'azoto dimostrano come la dieta di questi cacciatori raccoglitori fosse incentrata principalmente sul consumo della carne di erbivori terrestri di taglia medio-grande, in linea con le ricostruzioni archeozoologiche. I valori degli isotopi dell'azoto del collagene osseo, tuttavia, differiscono tra gli individui esaminati. Il presente studio valuta se questa differenza sia legata ai cambiamenti ambientali intercorsi tra le vite dei diversi inumati in questione o se sia dovuta al consumo di risorse acquatiche da parte di alcuni di essi
Neoadjuvant Therapy for Ovarian Cancer Using BioglycogenTM Nanoparticles SBIR Grant Proposal
Get PDFProject Summary Technical Abstract This Small Business Innovation Research Phase I project, presented by Talamo Inc., is to test an ovarian cancer therapeutic delivery system, comprised of a nanoscale biocompatible vesicle that carries a bioactive small interfering RNA molecule (siRNA), in vivio in mice. The siRNA has shown to reduce the expression of an enzyme (Sod2) that is highly expressed in multiple ovarian cancer types. The reduced expression of Sod2 will allow the tumor to become increasingly susceptible to chemotherapy agents, while simultaneously diminishing tumor progression. Research has proved that the nanoscale vesicle is non-toxic and in combination with siRNA effectively reduced Sod2 expression, in vitro, in ovarian cancer cells. Based upon these findings Talamo, Inc. plans to move forward to in vivo mice testing. It is necessary to prove that the nanoscale vesicle system is effective in inhibiting Sod2 expression and is also non-toxic in mice. The funds from phase I of this Small Business Innovation Research (SBIR) grant will allow Talamo, Inc. to proceed with in vivo mice testing. The anticipated results are that the mice given the therapy will have smaller tumors and lower Sod2 levels than the control group. Commercialization Abstract This neoadjuvant therapy has great commercial potential. Ovarian cancer is the deadliest of the gynecologic cancers. There will be 14,030 deaths in 2013 from ovarian cancer and ranks as the 10th most common cancer among women. This therapy would be administered to a patient as soon as she was diagnosed with ovarian cancer. Immediate therapy would slow the tumor progression and increase sensitivity to chemotherapy agents. This would allow physicians more time to proactively treat or to remove the tumors. Thus, the survival rates of patients with clear cell carcinoma will increase. Talamo Inc. has established conditional collaboration with Bristol-Myers Squibb, if the nanoscale delivery system is proven to be non-toxic and effective at inhibiting Sod2 in mice. Thus, it is imperative for Talamo, Inc. to be awarded this SBIR Phase I grant in order to fund in vivo mice testing. If the results from the in vivo mice testing prove favorable, Bristol-Myers Squibb will fund Phase 1 FDA clinical trials in conjunction with the $1,000,000 SBIR Phase II award. Once this therapy has been brought to market, after passing Phase 1-3 FDA clinical trials, Talamo Inc. will use its profits to fund future R&D for nanoscale delivery wesicles to be used to treat other cancers that also exhibit high levels of Sod2
Introduction to volume
No full textEstimating population, urban and economic growth for Asian and African countries(United Nations 2014) highlights the need to draw up new design approaches that promote the development of original architectural languages appropriate to the local identity and to the new development models. These models support the consolidation and growth of local cultures and economies and at the same time aim at reducing energy consumption, minimizing environmental pollution, increasing the use of renewable sources and effectively responding to water demand.
Therefore, a change of paradigm is required, together with a novel approach to urban (and peri-urban and rural) planning and usage of territories. In this per-spective, a holistic view should influence the entire built environment, i.e. the configuration of goods, the structure and use of land and the way in which basic services—such as energy, water, food and waste treatment—are handled. It is about working to move away from the current model of linear urban metabolism—based on the ‘take-make-dispose’ approach—to a circular one, where the consumption of resources and the waste production are minimized.
The present book revolves around these issues and describes the contribution of the ABC Department of Politecnico di Milano regarding the multidisciplinary research and development (R&D) activities, carried (and being carried) out on these multifaceted issues. It presents a selection of innovative projects carried out in African countries, aiming at tackling two main areas: offering practical solutions to specific necessities and experimenting cost-effective methods and technologies that can be easily applied in order to achieve high-quality results
Archaeomagnetic data from Campania (Southern Italy): the <Medieval> furnace of Pratola Serra, Avellino.
No full textScience and Tecnology for Cultural Heritage, 4 (I) - 1995: 71-77. Pis
Archaeomagnetic data from Campania (Southern Italy): the <Medieval> furnace of Pratola Serra, Avellino.
No full textScience and Tecnology for Cultural Heritage, 4 (I) - 1995: 71-77. Pis
Re-manufacturing networks for tertiary architectures. Innovative organizational models towards circularity
Get PDFThis book deals with re-manufacturing, recondition, reuse and repurpose considered as winning strategies for boosting regenerative circular economy in the building sector. It presents many of the outcomes of the research Re-NetTA (Re-manufacturing Networks for Tertiary Architectures).
New organisational models and tools for re-manufacturing and re-using short life components coming from tertiary buildings renewal, funded in Italy by Fondazione Cariplo for the period 2019-2021.
The field of interest of the book is the building sector, focusing on various categories of tertiary buildings, characterized by short term cycles of use.
The book investigates the most promising strategies and organizational models to maintain over time the value of the environmental and economic resources integrated into manufactured products, once they have been removed from buildings, by extending their useful life and their usability with the lower possible consumption of other materials and energy and with the maximum containment of emissions into the environment. The text is articulated into three sections.
Part I BACKGROUND introduces the current theoretical background and identifies key strategies about circular economy and re-manufacturing processes within the building sector, focusing on tertiary architectures. It is divided into three chapters.
Part II PROMISING MODELS outlines, according to a proposed framework, a set of promising circular organizational models to facilitate re-manufacturing practices and their application to the different categories of the tertiary sectors: exhibition, office and retail. This part also reports the results of active dialogues and roundtables with several categories of operators, adopting a stakeholder perspective.
Part III INSIGHTS provides some insights on the issue of re-manufacturing, analyzed from different perspectives with the aim of outlining a comprehensive overview of challenges and opportunities for the application of virtuous circular processes within building sector. Part III is organized in four key topics: A) Design for Re-manufacturing; B) Digital Transformation; C) Environmental Sustainability; D) Stakeholder Management, Regulations & Policies
Construction Technologies and Materials for Sustainable Affordable Housing
No full textWithin the dynamic and fragile context of developing countries, often characterized by social, political and economic uncertainty, the present chapter proposes a methodology for assessing and selecting appropriate building technologies for affordable housing, including a method for the systematic classification of building components. The aim is to investigate possible sustainable construction technologies and materials, taking a holistic perspective that allows overcoming the mere economic assessment. Hence, the chapter highlights possible perspectives for the improvement of current building solutions and practices in Mogadishu toward industrialization of construction, use of local raw materials and enhancement of construction quality through training
System and method for improving reliability of distributed electronic transactions
No full textA system and method are disclosed that separate control functionality from the management functionality for conducting electronic transactions. The control functions are performed by a third party resulting in a low overhead since significant overhead is incurred in response to an anomalous event, thus facilitating high throughput electronic transactions when anomalous events are infrequent. Further, the third party does not need to have access to confidential information since it only controls by observing, validating and certifying the observed communications in a specified manner to prevent confidential information from leaving the context of the transaction. Management of the transactions based on consideration of substantive information is provided by the participants. A preferred system of the invention comprises a validation authority, a logical boundary at which validation authority undertakes control of communications, and validation rules specifying parameters for observation and the nature of comparisons
Efficient data structure for lattice operations
No full textIn this paper, we consider the representation and management of an element set on which a lattice partial order relation is defined. In particular, let n be the element set size. We present an O(n root n)-space implicit data structure for performing the following set of basic operations: 1. Test the presence of an order relation between two given elements, in constant time. 2. Find a path between two elements whenever one exists, in O(l) steps, where l is the path length. 3. Compute the successors and/or predecessors set of a given element, in O(h) steps, where h is the size of the returned set. 4. Given two elements, find all elements between them, in time O(k log d), where k is the size of the returned set and d is the maximum in-degree or out-degree in the transitive reduction of the order relation. 5. Given two elements, find the least common ancestor and/or the greatest common successor in O(root n)-time. 6. Given k elements, find the least common ancestor and/or the greatest common successor in O(root n + k log n)time. (Unless stated otherwise, all logarithms are to the base 2.) The preprocessing time is O(n(2)). Focusing on the first operation, representing the building-box for all the others, we derive an overall O(n root n)-space x time bound which beats the order n(2) bottleneck representing the present complexity for this problem. Moreover, we will show that the complexity bounds for the first three operations are optimal with respect to the worst case. Additionally, a stronger result can be derived. In particular, it is possible to represent a lattice in space O(n root t), where t is the minimum number of disjoint chains which partition the element set
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