6,213 research outputs found
Syntheses and 3D-Structural Analyses of α,β-Didehydroalanine- and α,β-Didehydrovaline-Homopeptides.
No full textIn: "Peptide Science 2005". T. Wakamiya, Ed., The Japanese Peptide Society, Osaka, Japan, 2006, pp. 381-384
How ICTs Raise Manufacturing Performance: Firm-level Evidence in Southeast Asia.
No full textThis paper examines the effects of information and communication technologies (ICTs) on business performance, using firm-level data obtained through a questionnaire survey in four ASEAN countries (Indonesia, The Philippines, Thailand and Vietnam). Sources of information and new technologies exchanged via ICTs by firms are also explored to investigate the mechanism behind ICT adoption. Empirical results verify that the introduction of ICT to reorganize business processes is significantly correlated with business performance, in particular the development of export markets and improvement of production management. ICTs facilitate access to information and technologies accumulated in in-house departments and joint-venture (JV) affiliates of the respondent firms. There are considerable differences between multinational companies (MNCs)/JVs and local firms. MNCs/JVs make use of information and technologies obtainable via ICTs from their own R&D departments, JVs established with local partners and foreign-owned suppliers/customers to improve factory management, mostly for product quality improvement and production cost reduction. In contrast, local firms interconnect their own R&D departments via ICTs to enhance their business performance in broader areas than MNCs/JVs, including the development of export markets.
393. Tsuji Zennosuke (1877-1955)
No full textIwao Seiichi, Iyanaga Teizō, Ishii Susumu, Yoshida Shōichirō, Fujimura Jun'ichirō, Fujimura Michio, Yoshikawa Itsuji, Akiyama Terukazu, Iyanaga Shōkichi, Matsubara Hideichi. 393. Tsuji Zennosuke (1877-1955). In: Dictionnaire historique du Japon, volume 19, 1993. Lettre T. pp. 147-148
Uomini, libri e immagini. Per una storia del libro illustrato dal tardo antico al medioevo
No full textL'opera propone una raccolta di studi dedicata alla storia del libro illustrato. La miscellanea, radunata dalla curatrice, propone in versione italiana rivista e aggiornata, testi di Kurt Weitzmann, Ernst Kitzinger, Sahoko Tsuji, Erwin Panofsky, Jonathan J. Alexander, Patricia Stirnemann e Marie -Thérèse Gousset. L'edizione italiana dei testi è arricchita da contributi personali di alcuni autori. E' questo il caso dei saggi di Ernst Kitzinger e Sahoko Tsuji, da considerarsi una riedizione degli studi originali. L'antologia è corredata da un’introduzione, un glossario e un breve compendio di orientamenti bibliografici redatti dalla curatrice
Enantioselective Tsuji Allylations
No full textThe family of allylation reactions developed by Tsuji in the 1980s are capable of generating tertiary and quaternary carbon stereocenters from several synthetic precursors. Despite the utility of these transformations, they have seen little use in the synthesis of natural products. Recently, the power of these reactions was significantly enhanced by the development of enantioselective versions of these transformations. Applications of these methods to the enantioselective syntheses of natural products and pharmaceutical compounds highlight the importance of these developments
Experimental study on a nonlinear vibration isolator based on a post-buckled inverted L-shaped beam
No full textIn this paper, the characteristics and the effectiveness of a nonlinear passive vibration isolator based on apost-buckled beam is investigated experimentally. The intended application is specifically isolation in thevertical direction where the isolator is required to be sufficiently stiff statically to bear the weight of theisolated mass. The isolator consists of two beams joined to form an inverted L-shape and the weight of theisolated mass is taken to act at the vertex. If the weight of isolated mass is larger than the buckling load of theL-shaped beam then the beam buckles in one of two modes, one of which is unstable. In this paper, the staticrestoring force of the unstable mode is measured and an appropriately selected coil spring is added tocounteract the negative stiffness of the beam. The resulting system presents a dramatically lower stiffness tosmall excursions about its equilibrium position in its buckled state but maintains its static load bearingcapability. Free vibration measurements are presented which show some amplitude dependency of the naturalfrequency for large amplitude motion. Low amplitude harmonic base excitation measurements are alsoconducted from which transmissibility measurements are obtained and compared with corresponding resultsfrom a Finite Element model. The fundamental resonance is about 80% lower than that achievable by acomparable linear isolator. However the potential improvement in isolation performance has not been fullyrealised in the prototype design due to the presence of higher frequency internal resonances of the isolator,mitigation of which is the focus of ongoing work
Characteristics of overlap region in high-Reynolds number turbulent channel flow
No full textDirect numerical simulation of the fully developed turbulent channel flows have been carried out at the Reynolds number based on the friction velocity and the channel half width, 2000, 4000 and 8000. A hybrid 10th order accurate finite difference scheme in the stream and spanwise directions, and a second-order scheme in the wall-normal direction is adapted as the spatial discretization method. We observed the plateau profiles in the indicator function corresponded to the von Karman constant. Furthermore, second peak of streamwise pre-multiplied spectra were appeared in the same wall normal height, 300 < y+ < 600, in case of Re = 4000. Nevertheless, the effects of the lager than the channel half height scale on the streamwise turbulent intensity are fixed contributions without dependence on Reynolds number. These results suggested that the new streamwise vortexes are formed between buffer layer and outer layer with increasing of Reynolds number
Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice
No full textAbstractA number of studies have shown that CD8+ T cells mediate protective anti-malaria immunity in a mouse model. However, whether human CD8+ T cells play a role in protection against malaria remains unknown. We recently established human immune system (HIS) mice harboring functional human CD8+ T cells (HIS-CD8 mice) by transduction with HLA-A∗0201 and certain human cytokines using recombinant adeno-associated virus-based gene transfer technologies. These HIS-CD8 mice mount a potent, antigen-specific HLA-A∗0201-restricted human CD8+ T-cell response upon immunization with a recombinant adenovirus expressing a human malaria antigen, the Plasmodium falciparum circumsporozoite protein (PfCSP), termed AdPfCSP. In the present study, we challenged AdPfCSP-immunized HIS-CD8 mice with transgenic Plasmodium berghei sporozoites expressing full-length PfCSP and found that AdPfCSP-immunized (but not naïve) mice were protected against subsequent malaria challenge. The level of the HLA-A∗0201-restricted, PfCSP-specific human CD8+ T-cell response was closely correlated with the level of malaria protection. Furthermore, depletion of human CD8+ T cells from AdPfCSP-immunized HIS-CD8 mice almost completely abolished the anti-malaria immune response. Taken together, our data show that human CD8+ T cells mediate protective anti-malaria immunity in vivo
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