8,505 research outputs found
The Stroms of South Carolina - Accession 715 no. 24
No full textThe Stroms of South Carolina, 1765-1983 and Certain Allied Families by Samuel T. Strom, Sr. and Martha J. Strom chronicles the Strom family from their arrival in Charleston, S.C. in 1765 to 1984. U.S. Senator Strom Thurmond was a part of this family. Included in the book are photographs, maps, lineage charts, transcriptions of family documents, lists of servicemen and women and an index. Allied family names include Broadwater, Christian, Corley, Flynn (Flinn) Lanier, and Thurmond. Please see attached Table of Contents and Index.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2370/thumbnail.jp
Aminopeptidase N (CD13) expression on synovial fluid T lymphocytes from psoriatic arthritis patients
No full textBackground: T lymphocyte activation is responsible for articular damage in the course of chronic polyarthritides. The occurrence of T lymphocytes expressing early, intermediate and late activation markers shows a significant increase in synovial fluid (SF)respect to the peripheral blood (PB). Aminopeptidase (CD13) is an activation surface molecule expressed on different cell types except PB T lymphocytes. Objectives: To evaluate the appearance of aminopeptidase N (CD13) on SF T lymphocytes from psoriatic arthritis (PsA) patients, where it has never been investigated, to understand its contribution to the pathogenesis of this disease in relation to other activation molecules. Methods: We obtained SF and PB samples from 13 patients with PsA diagnosed by the presence of psoriasis and seronegative peripheral arthritis [M/F=11/2; mean age=40 yrs (range=24-57); mean disease duration=68 months (range=4-120)] and 11 subjects with rheumatoid arthritis (RA) classified according to Arnett criteria [M/F=3/8; mean age=55 yrs (range=24-70); mean disease duration=90 months (range=4-196)] presenting a knee joint effusion. For all of them we evaluated the main clinical and laboratory parameters including number of painful and swollen joints, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor and analysis of SF, obtained by therapeutic arthrocentesis. Besides, we performed SF and PB T lymphocyte analysis by direct dual immunofluorescence and flow cytometry using anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD13, anti-CD69, anti-CD25, anti-CD71 and anti-HLA-DR monoclonal antibodies. PB T cell subsets were also examined in 14 healthy donors matched for sex and age. Results: CD13 was expressed by SF T lymphocytes only and its presence did not significantly differ between PsA and RA patients. A significant increase in the number and percentage of CD69+ and HLA-DR+ T cells in SF compared to PB was seen both in PsA and RA. The absolute number of CD13+ T lymphocytes positively correlated with that of HLA-DR+ T cells in PsA (rs 0.839; p<0.0054) and RA (rs 0.781; p<0.019) patients.We did not find any difference in the expression of PB lymphocyte activation markers among PsA, RA and controls.Conclusion: Our results confirm that activated T lymphocytes in PsA and RA SF outnumber those in PB, sustaining the possibility that joint injury may derive from an inflammatory response towards an intraarticular antigen, in which CD13, expressed by SF T lymphocytes only, plays a prominent role.References: 1. Smith MD, Roberts-Thomson PJ. Lymphocytes surface marker expression in rheumatic diseases: evidence for prior activation of lymphocytes in vivo. Ann Rheum Dis 1990; 49: 81-7.2. Riemann D, Schwachula A, Hentschel M, Langner J. Demonstration of CD13/aminopeptidase N on synovial fluid T cells from patients with different forms of joint effusions. Immunobiology 1993; 187: 24-35
Composting of aged reed bed biosolids for beneficial reuse: a case study in New Jersey, USA
No full textReed beds with Phragmites australis (common reed) have been utilized to decrease the water, nutrient and volatile solids content of sewage sludge. An efficient disposal/reuse option was sought for reed bed biosolids accumulated over a 15 year period at a wastewater treatment facility in New Jersey, USA. The study facility had 14 reed beds, each with 1000 wet tons capacity, which were full, and so the solids needed to be removed. Because P. australis is considered an invasive species in New Jersey and several other states in the United States, disposal or reuse of solids containing this plant is regulated. Composting was examined as a potential treatment for destroying the plant’s reproductive rhizomes. The high temperatures achieved during composting were also tested to determine if regulatory criteria for pathogen reduction could be met, making the composted product suitable for unrestricted land application. Preliminary studies indicated the sludge had stabilized to the point where self-heating did not occur. Among the carbon amendments tested in the laboratory to stimulate compositing activity, Phragmites above ground biomass was determined to be most suitable. In a field test, Phragmites above ground biomass was mixed with reed bed biosolids at a 1:2 (w/w) ratio. The temperatures achieved resulted in complete mortality of Phragmites rhizomes. In laboratory tests, rhizomes placed in a drying oven at 50ºC for 24 hours, or 55ºC for 12 hours, showed 100% plant mortality. However, under field conditions pile temperatures could not be maintained long enough for the sludge to meet the USEPA 503 biosolids time-temperature pathogen rule requirements for unrestricted land application, even though sample fecal coliform counts did meet regulatory limits.Peer reviewed
Natural killer cells and gamma/delta T cells in synovial fluid and in peripheral blood of patients with psoriatic arthritis
No full textObjective NK surface markers and y/delta TCR antigen are involved in non-MHC-restricted cytotoxicity which represents a major effector mechanism of the cell-mediated immune response. We evaluated in PsA patients SF and PB lymphocytes expressing these cellular subsets in order to obtain information on the possible role played by them in the disease. Methods We studied 29 PsA and 27 RA patients, as well as 27 healthy controls. In 17 PsA and 16 RA patients with knee joint effusion, analysis of SF was performed. SF and PB lymphocyte analysis was performed by direct dual immunofluorescence flow cytometry using anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-TCR-gamma/delta-1 and anti-CD16 and anti-CD56 monoclonal antibodies. Results PsA and RA patients had, with respect to controls, lower values (both as percentages and in absolute numbers) of PB T cells expressing gamma/delta TCR. SF lymphocytes of PsA and RA patients were characterised, as compared to PB lymphocytes, by lower numbers (both in absolute numbers and in relative terms) of NK and NK-T cells. Considering the absolute numbers of the various lymphocyte subsets, a strong correlation was found in PsA SF between gamma/delta T cells and NK (p < 0.0007) or NK-T cells (p < 0.0003), as well as between NK and NK-T cells (p < 0.0019). There was instead no statistically significant correlation among the different SF or PB lymphocytes and the most relevant clinical or serological parameters. Conclusion This study analyzing the impairment of different subsets involved in non-MHC-restricted cytotoxicity, suggests that this component of the cell-mediated immune response seems to play a pivotal role in the development of PsA
State Employee Salaries Will Only Be Cut as a Last Resort
No full textStatement read by the Hon. John T. Sloan III to the South Carolina State Employees Association regarding the potential for salary cuts
U.S. Vice President Spiro T. Agnew and U.S. Senator Strom Thurmond sitting by flag and in front of crowd
No full textU.S. Vice President Spiro T. Agnew and U.S. Senator Strom Thurmond sitting by flag and in front of crowd,https://digitalcommons.coastal.edu/fleming-photos/1751/thumbnail.jp
Reduced circulating natural killer T cells and gamma/delta T cells in patients with systemic sclerosis
No full textObjective. To evaluate peripheral blood mononuclear cells (PBMC) expressing natural killer (NK) cell surface markers (CD16 and CD56, in both CD3- and CD3+ cells) and gamma/delta T cell receptors (TCR) involved in non-MHC-restricted cytotoxicity, assessing their possible relationship with clinical and laboratory variables in patients with systemic sclerosis (SSc). Methods. We submitted 50 patients with SSc to detailed clinical and laboratory assessment, and also performed PBMC subset analyses by direct dual immunofluorescence and flow cytometry. Results. No statistically significant differences were found in the percentages or the absolute numbers of total lymphocytes, of B cells, and of CD4+ T cells. The absolute number of CD8+ cells was lower (p < 0.03), while HLA-DR+ elements were higher in frequency (p < 0.03) in SSc patients than in healthy controls. SSc patients had lower values (both percentage and absolute number) of NK-T cells (p < 0.01 and p < 0.003, respectively) and of T cells expressing gamma/delta TCR (p < 0.01 and p < 0.005, respectively); whereas NK cells were marginally but not significantly decreased. The absolute number of NK-T cells showed an inverse correlation to erythrocyte sedimentation rate values (p < 0.03; r(s) = -0.306), percentage of gamma-globulins (p < 0.01; r(s) = -0.353), and serum concentrations of IgG (p < 0.02; r(s) = -0.334). Conclusion. Impairment of NK-T cells and of T cells expressing gamma/delta TCR may lead to downregulation of normal immune response, and seems to be important for immunological and inflammatory aspects of SSc
Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?
No full textA depletion of natural killer (hTK) cells seems to play a role in the course of systemic lupus erythematosus (SLE) whereas the possible involvement in this disease of T cell receptor (TCR) gamma/delta positive T cells is still debated. The aim of this study was to evaluate the peripheral blood mononuclear cells (PBMCs) that express NK surface markers CD16 and CD56 or gamma/delta TCR antigen in 58 SLE patients, investigating the possible role of these cell subsets involved in non-MHC-restricted cytotoxicity and their relationship with the main clinical and laboratory parameters. SLE patients had, with respect to controls, considerably decreased values of NK cells (P < 0.0004 in percentage and P < 0.00004 as absolute number), of non-MHC-restricted T cytotoxic lymphocytes (P < 0.007 and P < 0.0015, respectively) and of T cells expressing gamma/delta TCR (P < 0.02 and P < 0.004, respectively). The absolute numbers of these cell subsets positively correlated to each other (P < 0.009). gamma/delta T cells inversely correlated with higher ESR values, both percentually (P < 0.006; r = -0.367) and in absolute number (P < 0.009; r = -0.350). Moreover, the percentage values of this cell subset inversely correlated with higher levels of CRP (P < 0.05; r = -0.256) while SLE patients with anti-SSB/La antibodies had lower values of T lymphocytes bearing gamma/delta TCR, both as percentage (P < 0.008) and as absolute number (P < 0.02). Our study indicates that non-MHC-restricted cytotoxicity, shared by NK, NK-like and gamma/delta T cells, may be down-regulated in SLE patients, owing to a significant reduction of these PBMC subsets. These specific cell subset impairments seem to affect only some aspects of the disease, suggesting a weakening of the regulatory properties of these cells in the control of different immunological and inflammatory features of SLE, that could be of importance in its clinical expression
Suchbewegungen gegen den Strom: Für eine Soziologie der ganzen Arbeit.
No full textHaubner T. Suchbewegungen gegen den Strom: Für eine Soziologie der ganzen Arbeit. In: Atzmüller R, ed. Gesellschaft in Transformation: Sorge, Kämpfe und Kapitalismus. . Weinheim/Basel: Beltz-Juventa; 2024
- …
