4,973 research outputs found
Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction
No full textA. Burri, Q. Rahman and T. Spector (2011). Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction. Psychological Medicine, 41, pp 2435-2445. Copyright © Cambridge University Press 2011. http://dx.doi.org/10.1017/S003329171100049
Research Designs
No full textAuthor Paul E. Spector provides a clear introduction to the principles of experimental and non-experimental design, including single group design, pre-test, post-test designs, and factorial designs. Spector also covers hierarchical designs, multivariate designs, the Solomon four group design, panel designs, and designs with concomitant variables
Twin studies advance the understanding of gene-environment interplay in human nutrigenomics
No full textInvestigations into the genetic architecture of diet-disease relationships are particularly relevant today with the global epidemic of obesity and chronic disease. Twin studies have demonstrated that genetic makeup plays a significant role in a multitude of dietary phenotypes such as energy and macronutrient intakes, dietary patterns, and specific food group intakes. Besides estimating heritability of dietary assessment, twins provide a naturally unique, case-control experiment. Due to their shared upbringing, matched genes and sex (in the case of monozygotic (MZ) twin pairs), and age, twins provide many advantages over classic epidemiological approaches. Future genetic epidemiological studies could benefit from the twin approach particularly where defining what is 'normal' is problematic due to the high inter-individual variability underlying metabolism. Here, we discuss the use of twins to generate heritability estimates of food intake phenotypes. We then highlight the value of discordant MZ pairs to further nutrition research through discovery and validation of biomarkers of intake and health status in collaboration with cutting-edge omics technologies.</p
Value Pluralism and the Two Concepts of Rights
No full textPhilosophers and legal theorists still disagree about the correct analysis of 'rights', both moral and legal. The 'Will Theory' and the 'Interest Theory' - the two main views - can each account for various features of rights, but neither of them is totally satisfactory. The controversy has now been running for decades and seems irresolvable. I will contend in this paper that the discussion of 'value pluralism' in the Berlinian tradition can illuminate the debate over the concept of rights.analysis of rights, moral rights, legal rights, will theory, interest theory, value pluralism, Isaiah Berlin
E-Spector: Online Energy Inspection for Android Applications
No full textEnergy consumption is one of the most important aspects of mobile apps. During energy testing, it is important for developers to understand not only the energy consumption rate of an app, but also why energy is consumed. However, existing energy testing tools are more concerned about the accuracy of energy estimation, while typically not providing explanations on why and how exactly energy has been consumed. This paper presents E-Spector, an online energy inspection method for Android apps, which can not only visualize the energy consumption of an app in an instant online manner, but also can tell what happened behind each energy hotspot on the energy curve. E-Spector relies on static analysis and app instrumentation to collect the activities from an app execution in real-time. Then it presents the activities on an instant energy curve, such that the user can easily tell what happened behind each energy spike. Experimental result shows that the energy estimation error of E-Spector is less than 10% and its overhead on energy consumption is about 4%. We also show case studies to demonstrate the applicability and effectiveness of E-Spector in energy monitoring, analysis and bug inspection.National Key Research and Development Program [2016YFB1000105]; National Natural Science Foundation of China [61421091]CPCI-S(ISTP
Critique [of Asians, Jews, and the Legacy of Midas by Alan Spector]
No full textThe author of Asians, Jews, and the Legacy of Midas presents a provocative comparative analysis of Asians and Jews. Spector utilizes both a cultural and economic basis for understanding the function of Asian stereotyping and applies his analysis to the Jewish situation. While the American context provides the locus of his research, he does present his argument in an international context. Spector illustrates how the categorization of Asians and Jews as the model for economic success is dehumanizing as such a perception drain(s) the life out of human beings and concretizes them into non-human statues. The conclusion of this author\u27s work in dealing with oppression based in stereotype is actually a starting point which scholars should begin addressing. To be sure, the model minority, as applied to Asians and Jews, has generated numerous articles and papers, and yet scholars have failed to develop analyses which reflect an interdisciplinary and historical approach to the reasons for propagating such stereotypes
Blood, urine and faecal metabolite profiles in the study of adult renal disease
No full textChronic kidney disease (CKD) is a major public health burden and to date traditional biomarkers of renal function (such as serum creatinine and cystatin C) are unable to identify at-risk individuals before the disease process is well under way. To help preventive strategies and maximize the potential for effective interventions, it is important to characterise the molecular changes that take place in the development of renal damage. Metabolomics is a promising tool to identify markers of renal disease since the kidneys are involved in the handling of major biochemical classes of metabolites. These metabolite levels capture a snap-shot of the metabolic profile of the individual, allowing for the potential identification of early biomarkers, and the monitoring of real-time kidney function. In this review, we describe the current status of the identification of blood/urine/faecal metabolic biomarkers in different entities of kidney diseases including: acute kidney injury, chronic kidney disease, renal transplant, diabetic nephropathy and other disorders.</p
Patients who have had fractures ?f the distal forearm do not lose bone as expected
No full textEditor - Women's lifetime risk of experiencing a fracture of the distal forearm is 15%.x Such fractures are associated with considerable pain and morbidity. They are also associated with an increased risk of vertebral fracture,2 although these anatomical sites have different bone compositions, with the forearm being composed predominantly of cortical bone whereas the spin
Mechanisms of top-down facilitation in perception of visual objects studied by fMRI
No full textPrior knowledge regarding the possible identity of an object facilitates its recognition from a degraded visual input, though the underlying mechanisms are unclear. Previous work implicated ventral visual cortex but did not disambiguate whether activity-changes in these regions are causal to or merely reflect an effect of facilitated recognition. We used functional magnetic resonance imaging to study top-down influences on processing of gradually revealed objects, by preceding each object with a name that was congruent or incongruent with the object. Congruently primed objects were recognized earlier than incongruently primed, and this was paralleled by shifts in activation profiles for ventral visual, parietal, and prefrontal cortices. Prior to recognition, defined on a trial-by-trial basis, activity in ventral visual cortex rose gradually but equivalently for congruently and incongruently primed objects. In contrast, prerecognition activity was greater with congruent priming in lateral parietal, retrosplenial, and lateral prefrontal cortices, whereas functional coupling between parietal and ventral visual (and also left lateral prefrontal and parietal) cortices was enhanced in the same context. Thus, when controlling for recognition point and stimulus information, activity in ventral visual cortex mirrors recognition success, independent of condition. Facilitation by top-down cues involves lateral parietal cortex interacting with ventral visual areas, potentially explaining why parietal lesions can lead to deficits in recognizing degraded objects even in the context of top-down knowledge
Job Satisfaction: Applications, Assessment, Causes and Consequences
No full textDistilling the vast literature on this frequently studied variable in organizational behaviour research, Paul E Spector provides the student and professional with a pithy overview of the application, assessment, causes and consequences of job satisfaction. In addition to discussing the nature of and techniques for assessing job satisfaction, the author summarizes the findings concerning how people feel towards work, including: cultural and gender differences in job satisfaction and personal and organizational causes; and potential consequences of job satisfaction and dissatisfaction. Students and researchers will particularly appreciate the extensive list of references and the Job Satisfaction Survey included in the Appendix
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