725 research outputs found
Fig. 2 in Morphometric Variation Of Hybridizing Species And Gynogenetic Biotypes Of Spined Loaches (Cobitidae, Cobitis) In River Systems Of Ukraine
No full textFig. 2. Body measurements for Cobitis. Th e original fish image is from Wilhelm von Wright out of Fries, 1895.Published as part of Mezhzherin, S. V., Pavlenko, L. I., Tsyba, A. O., Saliy, T. V. & Ghazali, M. A., 2020, Morphometric Variation Of Hybridizing Species And Gynogenetic Biotypes Of Spined Loaches (Cobitidae, Cobitis) In River Systems Of Ukraine, pp. 285-298 in Zoodiversity 54 (4) on page 287, DOI: 10.15407/zoo2020.04.285, http://zenodo.org/record/645556
Induction of t-cell responses against PSA by plasmid DNA immunization
No full textThis thesis is focused on using plasmid DNA encoding human prostate-specific antigen (PSA) for immunotherapy of prostate cancer. PSA is a secreted serine protease, which is produced almost exclusively by prostate epithelial cells. It is also expressed by prostate epithelial cells after malignant transformation and thus can be considered a tumor-associated antigen for prostate cancer. In our studies we investigated the potency of DNA vaccines to induce PSA-specific CD8+ cytotoxic T lymphocytes (CTLs), which can efficiently target and eliminate PSA-producing tumor cells.In the first study we evaluated the efficacy of PSA-encoding plasmid DNA (pVax-PSA) in inducing T cell responses in patients with hormone-refractory prostate cancer. The plasmid DNA was administered during five cycles in doses of 100, 300 and 900μg, with three patients in each cohort. We demonstrated in this study that the pVax-PSA vaccine given in doses of 900μg is safe and can induce cellular immune responses against PSA.The major aim of the following studies was to characterize the potency of pVax-PSA plasmid in inducing CD8+ T-cell responses in a mouse model. We demonstrated that the pVax-PSA plasmid is highly immunogenic in mice, with just one DNA immunization being sufficient to induce potent CTL responses against PSA. Additional modifications of human PSA, by linking it to heat shock proteins of different origin (pVax-PSA-HSPs plasmids), did not further increased the efficacy of pVax-PSA plasmid in inducing CTL responses or mediating protection against tumor challenge. We have also characterized the epitope specificity of CTLs induced after immunization of C57Bl/6 mice with the pVax-PSA plasmid.We demonstrated that the majority of PSA-specific CTLs were directed against a single H-2Db-restricted epitope HCIRNKSVIL65-74 of PSA. However, immunization of mice with pVax-PSA plasmid does not properly reflect the clinical settings, where endogenous expression of PSA may potentially lead to depletion of high-avidity CD8+ T cell precursors with PSA-specific reactivity. Nevertheless, our findings in this study, will allow us to address this relevant question in experiments with transgenic mice expressing human PSA in prostate tissue, once such model is available on C57Bl/6 background.In the last study, we investigated the role of activation of antigen-presenting cells (APCs) by the plasmid DNA backbone in the induction of CTL responses by DNA vaccines. A single immunization with pVax-PSA plasmid induced stronger CTL responses in wild-type than in TLR9- or MyD88-deficient mice. These results suggest that immunostimulatory activity of CpG-DNA is essential for efficient priming of CTLs after a single DNA immunization.Collectively, our findings demonstrate that DNA vaccines represent a promising modality for induction of PSA-specific T-cell responses. Detailed characterization of immunogenicity of pVax-PSA plasmid in C57Bl/6 mice establishes an experimental background for further evaluation of various strategies to increase its potency in inducing CTL responses in a PSA-transgenic murine model.List of scientific papersI. Pavlenko M, Roos AK, Lundqvist A, Palmborg A, Miller AM, Ozenci V, Bergman B, Egevad L, Hellstrom M, Kiessling R, Masucci G, Wersall P, Nilsson S, Pisa P (2004). A phase I trial of DNA vaccination with a plasmid expressing prostate-specific antigen in patients with hormone-refractory prostate cancer. Br J Cancer. 91(4): 688-94. https://pubmed.ncbi.nlm.nih.gov/15280930II. Pavlenko M, Roos AK, Leder C, Hansson LO, Kiessling R, Levitskaya E, Pisa P (2004). Comparison of PSA-specific CD8+ CTL responses and antitumor immunity generated by plasmid DNA vaccines encoding PSA-HSP chimeric proteins. Cancer Immunol Immunother. 53(12): 1085-92. https://pubmed.ncbi.nlm.nih.gov/15696608III. Pavlenko M, Leder C, Roos AK, Levitsky V, Pisa P (2005). Identification of an immunodominant H-2D(b)-restricted CTL epitope of human PSA. Prostate. 64(1): 50-59. https://pubmed.ncbi.nlm.nih.gov/15651071IV. Pavlenko M, Leder C, Moreno S, Levitsky V, Pisa P (2005). Induction of CTL responses by DNA immunization is improved in TLR9- and MyD88-deficient mice. [Manuscript]</p
Fig 5. 95 in Morphometric Variation Of Hybridizing Species And Gynogenetic Biotypes Of Spined Loaches (Cobitidae, Cobitis) In River Systems Of Ukraine
No full textFig 5. 95 % confidence ellipses of the biotypes in the morphospace of four between-group principal components calculated for indices. Mean groups of each biotype is marked with black point and designation.Published as part of Mezhzherin, S. V., Pavlenko, L. I., Tsyba, A. O., Saliy, T. V. & Ghazali, M. A., 2020, Morphometric Variation Of Hybridizing Species And Gynogenetic Biotypes Of Spined Loaches (Cobitidae, Cobitis) In River Systems Of Ukraine, pp. 285-298 in Zoodiversity 54 (4) on page 293, DOI: 10.15407/zoo2020.04.285, http://zenodo.org/record/645556
Fig. 3. 95 in Morphometric Variation Of Hybridizing Species And Gynogenetic Biotypes Of Spined Loaches (Cobitidae, Cobitis) In River Systems Of Ukraine
No full textFig. 3. 95 % confidence interval ellipses of the biotypes in the morphospace of bgPC1 and bgPC2 calculated for log10-transformed absolute traits. Each biotype means are marked with black points and names. The biotypes are explained in table 1.Published as part of Mezhzherin, S. V., Pavlenko, L. I., Tsyba, A. O., Saliy, T. V. & Ghazali, M. A., 2020, Morphometric Variation Of Hybridizing Species And Gynogenetic Biotypes Of Spined Loaches (Cobitidae, Cobitis) In River Systems Of Ukraine, pp. 285-298 in Zoodiversity 54 (4) on page 291, DOI: 10.15407/zoo2020.04.285, http://zenodo.org/record/645556
Astronomy Reports V. 44, I. 04
No full textdc.description[en_US]Astronomy Reports -- April 2000
Volume 44, Issue 4, pp. 209-277
A Model for the Spectrum of Sakurai's Object (V4334 Sgr)
Ya. V. Pavlenko and L. A. Yakovina
pp. 209-218 Full Text: PDF (172 kB)
Lithium Lines in the Spectra of M Dwarfs: UX Tau C
Ya. V. Pavlenko
pp. 219-226 Full Text: PDF (169 kB)
Abundances of C, N, O, and Other Elements in the Atmospheres of the delta Scuti Variables 14 Aur, delta Sct, and HD 127986
T. M. Rachkovskaya
pp. 227-234 Full Text: PDF (107 kB)
Quantitative Analysis of the Spectrum of the Magnetic roAp Star HD 83368 with "Lithium" Spots
A. V. Shavrina, N. S. Polosukhina, V. Tsymbal, and V. Khalak
pp. 235-245 Full Text: PDF (184 kB)
Solar Analogs: Spectral Energy Distributions and Physical Parameters of Their Atmospheres
I. N. Glushneva, V. I. Shenavrin, and I. A. Roshchina
pp. 246-254 Full Text: PDF (100 kB)
Solar Flares with Long Soft X-ray Decays: Energy Balance in Giant Loops
K. V. Getman and M. A. Livshits
pp. 255-261 Full Text: PDF (235 kB)
Large-Scale Solar Magnetic Field: Latitudinal Dependence
V. N. Obridko and B. D. Shelting
pp. 262-270 Full Text: PDF (811 kB)
Detection of a Cyclotron Line in the Radio Spectrum of a Solar Active Region and Its Interpretation
V. M. Bogod, V. I. Garaimov, V. V. Zheleznyakov, and E. Ya. Zlotnik
pp. 271-277 Full Text: PDF (125 kB)dc.description.contributor[en_US]dc.description.contributor[en_US
Astronomy Reports V. 44, I. 04
No full textAstronomy Reports -- April 2000
Volume 44, Issue 4, pp. 209-277
A Model for the Spectrum of Sakurai's Object (V4334 Sgr)
Ya. V. Pavlenko and L. A. Yakovina
pp. 209-218 Full Text: PDF (172 kB)
Lithium Lines in the Spectra of M Dwarfs: UX Tau C
Ya. V. Pavlenko
pp. 219-226 Full Text: PDF (169 kB)
Abundances of C, N, O, and Other Elements in the Atmospheres of the delta Scuti Variables 14 Aur, delta Sct, and HD 127986
T. M. Rachkovskaya
pp. 227-234 Full Text: PDF (107 kB)
Quantitative Analysis of the Spectrum of the Magnetic roAp Star HD 83368 with "Lithium" Spots
A. V. Shavrina, N. S. Polosukhina, V. Tsymbal, and V. Khalak
pp. 235-245 Full Text: PDF (184 kB)
Solar Analogs: Spectral Energy Distributions and Physical Parameters of Their Atmospheres
I. N. Glushneva, V. I. Shenavrin, and I. A. Roshchina
pp. 246-254 Full Text: PDF (100 kB)
Solar Flares with Long Soft X-ray Decays: Energy Balance in Giant Loops
K. V. Getman and M. A. Livshits
pp. 255-261 Full Text: PDF (235 kB)
Large-Scale Solar Magnetic Field: Latitudinal Dependence
V. N. Obridko and B. D. Shelting
pp. 262-270 Full Text: PDF (811 kB)
Detection of a Cyclotron Line in the Radio Spectrum of a Solar Active Region and Its Interpretation
V. M. Bogod, V. I. Garaimov, V. V. Zheleznyakov, and E. Ya. Zlotnik
pp. 271-277 Full Text: PDF (125 kB)Archived web conten
ExoMol line lists - III. An improved hot rotation-vibration line list for HCN and HNC
No full textA revised rotation-vibration line list for the combined hydrogen cyanide (HCN)/hydrogen isocyanide (HNC) system is presented. The line list uses ab initio transition intensities calculated previously and extensive data sets of recently measured experimental energy levels. The resulting line list has significantly more accurate wavelengths than previous ones for these systems. An improved value for the separation between HCN and HNC is adopted, leading to an approximately 25 per cent lower predicted thermal population of HNC as a function of temperature in the key 2000 to 3000 K region. Temperature-dependent partition functions and equilibrium constants are presented. The line lists are validated by comparison with laboratory spectra and are presented in full as supplementary data to the article and at www.exomol.com
Xhosalising English? Negotiating meaning and identity in economics
No full textThis is an Accepted Manuscript of an article published by Taylor & Francis in Southern African Linguistics and Applied Language Studies on 23 December 2010 available online: http://www.tandfonline.com/10.2989/16073614.2010.545027.As yet, very few South African studies have explored multilingual learning contexts in order to develop a better understanding of the role that students' diverse primary or hybrid languages play in meaning making in English medium universities.This paper will report on a project which set out to investigate code-switching practices in informal learning groups in the university and to distinguish the forms and functions of these code-switching practices. A particular focus has been to gain insights into the ways in which concepts transfer from one language to another in order to develop thinking on language and learning in multilingual contexts and extend theories of conceptual transfer. The particular focus of this paper is the pedagogic and social functions of this hybrid language and how its use might be tied to questions of identity. We look particularly at the way the tutor in the peer learning group used code-mixing to negotiate different identities in dealing with first a rural and then an urban group of students. We will also illustrate by means of our data ways in which English is being appropriated and Xhosalised, particularly by the urban group of students in order to negotiate meaning, identity and status on this campus and in the wider community
Astronomy Reports V. 47, I. 07
No full textAstronomy Reports -- July 2003
Volume 47, Issue 7, pp. 531-620
Galaxies and Stars
B. I. Fesenko
pp. 531-534 Full Text: PDF (104 kB)
Models of the Dust Envelope of the Unique Object FG Sagittae
M. B. Bogdanov and O. G. Taranova
pp. 535-539 Full Text: PDF (149 kB)
Calculation of Profiles of the CIV 1550 Doublet Formed in an Accretion Shock in a T Tauri Star: Axially Symmetric Radial Accretion
S. A. Lamzin
pp. 540-550 Full Text: PDF (254 kB)
Apsidal Motion and Physical Parameters of the Eclipsing Binary System AR Cas
A. V. Krylov, L. V. Mossakovskaya, Kh. F. Khaliullin, and A. I. Khaliullina
pp. 551-561 Full Text: PDF (272 kB)
Butterfly Diagram for Starspots on LQ Hya
M. A. Livshits, I. Yu. Alekseev, and M. M. Katsova
pp. 562-572 Full Text: PDF (289 kB)
Characteristic Features of the Spectrum of the Unique roAp Star HD 101065 near the 6708 Å Lithium Resonance Doublet
A. V. Shavrina, N. S. Polosukhina, Ya. V. Pavlenko, A. V. Yushchenko, and V. F. Gopka
pp. 573-579 Full Text: PDF (174 kB)
Photometric and Polarimetric Activity of RZ Psc
D. N. Shakhovskoi, V. P. Grinin, and A. N. Rostopchina
pp. 580-586 Full Text: PDF (212 kB)
Magnetic Fields of White Dwarfs
G. G. Valyavin, T. E. Burlakova, S. N. Fabrika, and D. N. Monin
pp. 587-599 Full Text: PDF (309 kB)
The Formation of Millisecond Radio Pulsars in Close Binary Systems
A. V. Tutukov and A. V. Fedorova
pp. 600-612 Full Text: PDF (322 kB)
The Electric Fields of Radio Pulsars with Asymmetric Nondipolar Magnetic Fields
E. M. Kantor and A. I. Tsygan
pp. 613-620 Full Text: PDF (194 kB)Archived web conten
Semiconductors V. 35, I. 12
No full textSemiconductors -- December 2001
Volume 35, Issue 12, pp. 1347-1417
ELECTRONIC AND OPTICAL PROPERTIES OF SEMICONDUCTORS
Paramagnetic Defects in Silicon Carbide Crystals Irradiated with Gamma-Ray Quanta
I. V. Ilyin, E. N. Mokhov, and P. G. Baranov
pp. 1347-1354 Full Text: PDF (117 kB)
Interaction of Hydrogen with Radiation Defects in p-Si Crystals
O. V. Feklisova, N. A. Yarykin, E. B. Yakimov, and J. Weber
pp. 1355-1360 Full Text: PDF (84 kB)
Electrical Properties of the Proton-Irradiated Semi-Insulating GaAs:Cr
V. N. Brudnyi and A. I. Potapov
pp. 1361-1365 Full Text: PDF (80 kB)
Dynamics of Nonequilibrium Gratings Induced in Silicon Films by Femtosecond Laser Pulses
M. F. Galyautdinov, V. S. Lobkov, S. A. Moiseev, and I. V. Negrashov
pp. 1366-1368 Full Text: PDF (55 kB)
Radiative Recombination via Direct Optical Transitions in In1 – xGaxAs (0 <= x <= 0.16) Solid Solutions
M. Aidaraliev, N. V. Zotova, S. A. Karandashev, B. A. Matveev, M. A. Remennyi, N. M. Stus', and G. N. Talalakin
pp. 1369-1371 Full Text: PDF (49 kB)
Effect of Structural Imperfection on the Spectrum of Deep Levels in 6H-SiC
A. A. Lebedev, D. V. Davydov, A. S. Tregubova, E. V. Bogdanova, M. P. Shcheglov, and M. V. Pavlenko
pp. 1372-1374 Full Text: PDF (457 kB)
SEMICONDUCTOR STRUCTURES, INTERFACES, AND SURFACES
The Contact of Metal with Silicon Carbide: Schottky Barrier Height in Relation to SiC Polytype
S. Yu. Davydov, A. A. Lebedev, O. V. Posrednik, and Yu. M. Tairov
pp. 1375-1377 Full Text: PDF (35 kB)
LOW-DIMENSIONAL SYSTEMS
Ostwald Ripening of Quantum-Dot Nanostructures
R. D. Vengrenovich, Yu. V. Gudyma, and S. V. Yarema
pp. 1378-1382 Full Text: PDF (60 kB)
Kinetics of Exciton Photoluminescence in Low-Dimensional Silicon Structures
A. V. Sachenko, É. B. Kaganovich, É. G. Manoilov, and S. V. Svechnikov
pp. 1383-1389 Full Text: PDF (145 kB)
Renormalization of Energy Spectrum of Quantum Dots under Vibrational Resonance Conditions
A. V. Fedorov, A. V. Baranov, A. Itoh, and Y. Masumoto
pp. 1390-1397 Full Text: PDF (111 kB)
AMORPHOUS, VITREOUS, AND POROUS SEMICONDUCTORS
Scanning Tunneling Spectroscopy of a-C:H and a-C:(H, Cu) Films Prepared by Magnetron Sputtering
T. K. Zvonareva, V. I. Ivanov-Omskii, V. V. Rozanov, and L. V. Sharonova
pp. 1398-1403 Full Text: PDF (78 kB)
PHYSICS OF SEMICONDUCTOR DEVICES
InAsSb/InAsSbP Double-Heterostructure Lasers Emitting in the 3–4 µm Spectral Range
T. N. Danilova, A. N. Imenkov, N. M. Kolchanova, and Yu. P. Yakovlev
pp. 1404-1417 Full Text: PDF (183 kB)Archived web conten
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