7,019 research outputs found
T 48 steam locomotive, Buckleboo, South Australia, (Port Lincoln Dwn) SAR, 1964 [picture] /
No full textCondition: Good.; Part of Collection: Buckland collection of railway transport photographs.; "T 48 Buckleboo (Pt Lincoln Dwn SAR) 2/1/64. JW Knowles neg 4043"--Handwritten on verso.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an24381194
[Travel Agent Appointment Agreement between C. M. Knowles, Grace Line, Inc. and T. N. Carswell, Carswell Agency]
No full textA travel agent appointment agreement between The Grace Line, Inc., 10 Hanover Square, New York 5, N. Y., signed by C. M. Knowles and Carswell Agency, Abilene, Texas, by T. N. Carswell, dated November 15, 1949. Signed by J. B. Dalton, witness
Marriage record of Knowles, Charles A. and Ward, Maggie T.
No full textMarriage license for Charles A. Knowles and Maggie T. Ward. Charles A. Gramling was the Notary Public
Ric Knowles
No full textRic Knowles holding his three new publications; "Afrika Solo", "Theatre and Interculturalism", and "Asian Canadian Theatre" at the Campus Author Recognition Program Annual Reception, October 27, 2011
John Knowles
No full textPorträt von John Knowles (1781-1741), Autor der Füssli Biographie: The Life and writings of Henry Fuseli, Esq. M.A.R.A. Keeper, and Professor of Painting to the Royal Academy in London ...Edited by John Knowles, 3 Bde., London 1831C. Landseer del[ineavi]t. ; W. D. Lith
Online_appendix – Supplemental material for Ideology in the schools: Developing the teacher’s Civic Education Ideology Scale within the United States
No full textSupplemental material, Online_appendix for Ideology in the schools: Developing the teacher’s Civic Education Ideology Scale within the United States by Ryan T Knowles in Education, Citizenship and Social Justice</p
The Maine Economy—Through a Different Lens
No full textWilliam Knowles, a banker “from away” who has retired to Maine, gives his thoughts about the state’s economy, based on his reading, research, and conversations with a variety of Mainers. He structures his examination using four different “lenses,” which he terms: comparisons (how does Maine compare with other states and regions), cultivation (economic development), capital (especially human capital), and culture. Knowles challenges readers to think about whether Maine’s culture or belief system may be an important factor in restraining economic development
An Account of the expedition to Carthagena : with explanatory notes and observations.
No full textAuthorship attributed to Captain (afterwards Admiral) Sir Charles Knowles. cf. Dict. nat. biog., v. 58, p. 272.Expedition of Admiral Vernon and General Wentworth.Mode of access: Internet
Prosthechea glauca Knowles & Westc., Fl. Cab.
No full textProsthechea glauca Knowles & Westc., Fl. Cab. 2: 111. 1838. Voucher: T. Hawkins 298 (EAP, MO).Published as part of Vega, Hermes, Cetzal-Ix, William, Mó, Edgar, Romero-Soler, Katya J. & Basu, Saikat K., 2022, An Updated Checklist of the Orchidaceae of Honduras, pp. 1-80 in Phytotaxa 562 (1) on page 67, DOI: 10.11646/phytotaxa.562.1.1, http://zenodo.org/record/707369
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
No full textProlonged Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels is crucial in activating the Ca(2+)-sensitive transcription factor NFAT, which is responsible for directing T cell proliferation and cytokine gene expression. To establish whether targeting CRAC might counteract intestinal inflammation, we evaluated the in vitro effect of a selective CRAC inhibitor on T cell cytokine production and T-bet expression by lamina propria mononuclear cells (LPMC) and biopsy specimens from inflammatory bowel disease (IBD) patients. The inhibitory activity of the CRAC blocker was investigated through patch-clamp experiments on rat basophilic leukemia cells and fluorometric imaging plate reader intracellular Ca(2+) assays using thapsigargin-stimulated Jurkat T cells and its detailed selectivity profile defined using a range of in vitro radioligand binding and functional assays. Anti-CD3/CD28-stimulated LPMC and biopsy specimens from 51 patients with IBD were cultured with a range of CRAC inhibitor concentrations (0.01-10 microM). IFN-gamma, IL-2, IL-8, and IL-17 were analyzed by ELISA. T-bet was determined by immunoblotting. We found that the CRAC blocker concentration-dependently inhibited CRAC current in rat basophilic leukemia cells and thapsigargin-induced Ca(2+) influx in Jurkat T cells. A concentration-dependent reduction in T-bet expression and production of IFN-gamma, IL-2, IL-17, but not IL-8, was observed in IBD LPMC and biopsy specimens treated with the CRAC inhibitor. In conclusion, we provide evidence that the suppression of CRAC channel function may dampen the increased T cell response in the inflamed gut, thus suggesting a promising role for CRAC inhibitor drugs in the therapeutic management of patients with IBD
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