30,287 research outputs found
Gu Xiong : The River
No full textGu Xiong’s installation “The River” is described by O’Brian as a meditation on migrancy and displacement. The author situates the work within the life of the artist, who left China because of political oppression, and the history of the Canadian West, which has marginalized its Chinese inhabitants. Short poetic texts by Gu Xiong in which he identifies with spawning salmon are included. Biographical notes. 19 bibl. ref
Gu\uedas Alimentarias en Am\ue9rica Latina: Informe de la consulta t\ue9cnica regional de las Gu\uedas Alimentarias
No full textEn seguimiento a los acuerdos de la Conferencia Internacional de Nutrici\uf3n, realizada en Roma en 1992 (1), el Instituto de Nutrici\uf3n de Centroam\ue9rica y Panam\ue1 - INCAP- y la Organizaci\uf3n Panamericana de la Salud -OPShan apoyado el desarrollo, implementaci\uf3n y evaluaci\uf3n de gu\uedas alimentarias en los pa\uedses de Am\ue9rica Latina, a trav\ue9s de talleres de capacitaci\uf3n, asistencia t\ue9cnica directa y transferencia de metodolog\uedas. Este cap\uedtulo presenta un resumen del proceso propuesto para la elaboraci\uf3n implementaci\uf3n y evaluaci\uf3n de las gu\uedas alimentarias y hace un an\ue1lisis de las gu\uedas alimentarias de Am\ue9rica.
I. Modelo propuesto para la elaboraci\uf3n de Gu\uedas Alimentarias
Las gu\uedas alimentarias, por definici\uf3n, son un instrumento educativo que adapta los conocimientos cient\uedficos sobre requerimientos nutricionales y composici\uf3n de alimentos en una herramienta pr\ue1ctica que facilita a la poblaci\uf3n la selecci\uf3n de una dieta saludable. Las gu\uedas alimentarias est\ue1n presentadas en forma sencilla y comprensible para que ayuden a personas sin conocimientos cient\uedficos de alimentaci\uf3n y nutrici\uf3n a seleccionar dietas sanas.
El modelo propuesto por el INCAP/OPS (2), toma en cuenta la informaci\uf3n sobre salud, alimentaci\uf3n y nutrici\uf3n, tal como el estado nutricional de la poblaci\uf3n, el perfil epidemiol\uf3gico, la informaci\uf3n acerca de la disponibilidad, costo, acceso y consumo de alimentos y la composici\uf3n qu\uedmica de los mismos, as\ued como los h\ue1bitos alimentarios de la poblaci\uf3n. A estos criterios se incorporan elementos de la antropolog\ueda social, que permiten adaptar las gu\uedas alimentar\uedas a la realidad social, cultural y econ\uf3mica del grupo objetivo..
A coalgebraic perspective on probabilistic logic programming
No full textProbabilistic logic programming is increasingly important in artificial intelligence and related fields as a formalism to reason about uncertainty. It generalises logic programming with the possibility of annotating clauses with probabilities. This paper proposes a coalgebraic perspective on probabilistic logic programming. Programs are modelled as coalgebras for a certain functor F, and two semantics are given in terms of cofree coalgebras. First, the cofree F-coalgebra yields a semantics in terms of derivation trees. Second, by embedding F into another type G, as cofree G-coalgebra we obtain a “possible worlds” interpretation of programs, from which one may recover the usual distribution semantics of probabilistic logic programming
Coalgebraic semantics for probabilistic logic programming
No full textProbabilistic logic programming is increasingly important in artificial intelligence and related fields as a formalism to reason about uncertainty. It generalises logic programming with the possibility of annotating clauses with probabilities. This paper proposes a coalgebraic semantics on probabilistic logic programming. Programs are modelled as coalgebras for a certain functor F, and two semantics are given in terms of cofree coalgebras. First, the cofree F-coalgebra yields a semantics in terms of derivation trees. Second, by embedding F into another type G, as cofree G-coalgebra we obtain a 'possible worlds' interpretation of programs, from which one may recover the usual distribution semantics of probabilistic logic programming. Furthermore, we show that a similar approach can be used to provide a coalgebraic semantics to weighted logic programming
Functorial semantics as a unifying perspective on logic programming
No full textLogic programming and its variations are widely used for formal reasoning in various areas of Computer Science, most notably Artificial Intelligence. In this paper we develop a systematic and unifying perspective for (ground) classical, probabilistic, weighted logic programs, based on categorical algebra. Our departure point is a formal distinction between the syntax and the semantics of programs, now regarded as separate categories. Then, we are able to characterise the various variants of logic program as different models for the same syntax category, i.e. structure-preserving functors in the spirit of Lawvere’s functorial semantics. As a first consequence of our approach, we showcase a series of semantic constructs for logic programming pictorially as certain string diagrams in the syntax category. Secondly, we describe the correspondence between probabilistic logic programs and Bayesian networks in terms of the associated models. Our analysis reveals that the correspondence can be phrased in purely syntactical terms, without resorting to the probabilistic domain of interpretation
Gu gong hua pu; Gao shi
No full textBen shu yi shi dai pai xu,Xuan qu zui ju dai biao xing de ming jia jing dian zhi zuo,Zhan shi bing fu yi ju bu da t
Insight into the Progress in CAR-T Cell Therapy and Combination with Other Therapies for Glioblastoma
No full textTingyu Liang,* Yixuan Song,* Lingui Gu, Yu Wang, Wenbin Ma Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenbin Ma; Yu Wang, Email [email protected]; [email protected]: Glioblastoma (GBM) is the most common malignant primary brain cancer in adults. It is always resistant to existing treatments, including surgical resection, postoperative radiotherapy, and chemotherapy, which leads to a dismal prognosis and a high relapse rate. Therefore, novel curative therapies are urgently needed for GBM. Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved life expectancy for hematological malignancies patients, and thus it increases the interest in applying CAR-T cell therapy for solid tumors. In the recently published research, it is indicated that there are numerous obstacles to achieve clinical benefits for solid tumors, especially for GBM, because of GBM anatomical characteristics (the blood–brain barrier and suppressive tumor microenvironment) and the tumor heterogeneity. CAR-T cells are difficult to penetrate blood–brain barrier, and immunosuppressive tumor microenvironment (TME), which induces CAR-T cell exhaustion, impairs CAR-T cell therapy response. Moreover, under the pressure of CAR-T cell therapy, the tumor heterogeneity and tumor plasticity drive tumor evolution and therapy resistance, such as antigen escape. Nonetheless, scientists strive for strategies to overcome these hurdles, including novel CAR-T cell designs and regional delivery. For instance, the structure of multi-antigen-targeted CAR-T cells can enrich CAR-T accumulation in tumor TME and eliminate abundant tumor cells to avoid tumor antigen heterogeneity. Additionally, paired with an immune modifier and one or more stimulating domains, different generation of innovations in the structure and manufacturing of CAR-T cells have improved efficacy and persistence. While single CAR-T cell therapy receives limited clinical survival benefit. Compared with single CAR-T cell therapy, the combination therapies have supplemented the treatment paradigm. Combinatorial treatment methods consolidate the CAR-T cells efficacy by regulating the tumor microenvironment, optimizing the CAR structure, targeting the CAR-T cells to the tumor cells, reversing the tumor-immune escape mechanisms, and represent a promising avenue against GBM, based on multiple impressive research. Moreover, exciting results are also reported to be realized through combining effective therapies with CAR-T cells in preclinical and clinical trials samples, have aroused inspiration to explore the antitumor function of combination therapies. In summary, this study aims to summarize the limitation of CAR-T cell therapies and introduces novel strategies to enhance CAR-T cell function as well as prospect the potential of the therapeutic combination.Keywords: CAR-T, GBM, novel strategies, therapeutic combinatio
Deng Erya jiu cang jia gu.
No full text李宗焜拓摹并題."鄧爾雅(一八八四-一九五四)舊藏甲骨. 一九六九年五月鄧祖玄奉母葉多福女士之命以其父爾雅先生所藏甲骨慨贈香港中文大學聯合書院. 二〇一五年夏移藏大學圖書館""乙未仲冬余應香港中文大學圖書館李露絲館長之邀為館藏甲骨之儲存與展示貢愚余以坐言不如起行遂為之董理重為類次並施拓摹携歸裱冊而還之且識數語以記因緣李宗焜於史語所""Deng Erya (yi ba ba si - yi jiu wu si) jiu cang jia gu. Yi jiu liu jiu nian wu yue Deng Zuxuan feng mu Ye Duofu nü shi zhi ming yi qi fu Erya xian sheng suo cang jia gu kai zeng Xianggang Zhong wen da xue Lian he shu yuan. Er ling yi wu nian xia yi cang Da xue tu shu guan""Yi wei zhong dong yu ying Xianggang Zhong wen da xue tu shu guan Li Lusi guan zhang zhi yue wei guan cang jia gu zhi chu cun yu zhan shi gong yu yu yi zuo yan bu ru qi xing sui wei zhi dong li chong wei lei ci bing shi tuo mo xie gui biao ce er huan zhi qie shi shu yu yi ji yin yuan Li Zongkun yu Shi yu suo"In accordion binding.Li Zongkun tuo mo bing ti
Expanding Ethical Horizons: Rethinking the Ethics of De 德 and Guṇa in the Laozi 老子 and Bhagavad-Gītā
No full textThis paper aims to engage in an ethical discussion of de in the Laozi and guṇa in the Bhagavad-Gītā to expand the horizon of our ethical understanding of Chinese and Indian philosophy. First, this paper will explore the different ethical levels of de and guṇa and discuss how these levels operate and are bound together. From an ethical perspective, this paper points out that de and guṇa can each be divided into two parts—higher de and lower de, and higher guṇa and lower guṇa. It will further explain the ethical significance of de and guṇa, arguing that they offer a unique contribution to developing our contemporary understanding of ethics. We will also seek to discover the interplay of de and/with the dao in the Laozi and that among the three guṇas in the Gītā from the perspective of human behaviors. In the conclusion, we will provide a comparative discussion of our findings on the ethics of de and guṇa in the Laozi and the Gītā. These findings suggest that de and guṇa promote a shared philosophical outlook within their respective traditions and thereby make a contribution to post-comparative ethical approaches
DataSheet1_Protective effect of compatible herbs in Jin-Gu-Lian formula against Alangium chinense-induced neurotoxicity via oxidative stress, neurotransmitter metabolisms, and pharmacokinetics.DOCX
No full textBackground:A. chinense frequently used in Miao medicine to treat rheumatic diseases. However, as a famous toxic herb, Alangium chinense and its representative components exhibit ineluctable neurotoxicity, thus creating significant challenges for clinical application. The combined application with compatible herbs in Jin-Gu-Lian formula attenuates such neurotoxicity according to the compatible principle of traditional Chinese medicines.Purpose: We aimed to investigate the detoxification of the compatible herbs in Jin-Gu-Lian formula on A. chinense-induced neurotoxicity and investigate its mechanism.Methods: Neurobehavioral and pathohistological analysis were used to determine the neurotoxicity in rats administered with A. chinense extract (AC), extract of compatible herbs in Jin-Gu-Lian formula (CH) and combination of AC with CH for 14 days. The mechanism underlying the reduction of toxicity by combination with CH was assessed by enzyme-linked immunosorbent assays, spectrophotometric assays, liquid chromatography tandem-mass spectrometry and real-time reverse transcription-quantitative polymerase chain reaction.Results: Compatible herbs attenuated the AC-induced neurotoxicity as evidenced by increased locomotor activity, enhanced grip strength, the decreased frequency of AC-induced morphological damage in neurons, as well as a reduction of neuron-specific enolase (NSE) and neurofilament light chain (NEFL) levels. The combination of AC and CH ameliorated AC-induced oxidative damage by modulating the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC). AC treatment significantly reduced the levels of monoamine and acetylcholine neurotransmitters in the brains of rats, including acetylcholine (Ach), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), norepinephrine (NE), and serotonin (5-HT). Combined AC and CH treatment regulated the abnormal concentrations and metabolisms of neurotransmitters. Pharmacokinetic studies showed that the co-administration of AC and CH significantly decreased plasma exposure levels of two main components of AC, as evidenced by the reduction of maximum plasma concentration (Cmax), area under the plasma concentration-time curve (AUC) compared to AC. In addition, the AC-induced downregulation in mRNA expression of cytochrome P450 enzymes was significantly reduced in response to combined AC and CH treatment.Conclusion: Compatible herbs in Jin-Gu-Lian formula alleviated the neurotoxicity induced by A. chinense by ameliorating oxidative damage, preventing abnormality of neurotransmitters and modulating pharmacokinetics.</p
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