451 research outputs found
Johannis Kunckelii, Churfürstl. Brandenb. würcklich bestallt-geheimden Cammer-Dieners/ Ars Vitraria Experimentalis, Oder Vollkommene Glasmacher-Kunst/ Lehrende/ als in einem/ aus unbetrüglicher Erfahrung herfliessendem Commentario, über die von dergleichen Arbeit beschriebenen Sieben Bücher P. Anthonii Neri, von Florentz ... Christophori Merretti, M.D. & Societ. Reg. Brittann. Socii, (so aus den Ital. und Latein. beyde mit Fleiß ins Hochdeutsche übersetzt) ...
No full textJOHANNIS KUNCKELII, CHURFÜRSTL. BRANDENB. WÜRCKLICH BESTALLT-GEHEIMDEN CAMMER-DIENERS/ ARS VITRARIA EXPERIMENTALIS, ODER VOLLKOMMENE GLASMACHER-KUNST/ LEHRENDE/ ALS IN EINEM/ AUS UNBETRÜGLICHER ERFAHRUNG HERFLIESSENDEM COMMENTARIO, ÜBER DIE VON DERGLEICHEN ARBEIT BESCHRIEBENEN SIEBEN BÜCHER P. ANTHONII NERI, VON FLORENTZ ... CHRISTOPHORI MERRETTI, M.D. & SOCIET. REG. BRITTANN. SOCII, (SO AUS DEN ITAL. UND LATEIN. BEYDE MIT FLEISS INS HOCHDEUTSCHE ÜBERSETZT) ...
Johannis Kunckelii, Churfürstl. Brandenb. würcklich bestallt-geheimden Cammer-Dieners/ Ars Vitraria Experimentalis, Oder Vollkommene Glasmacher-Kunst/ Lehrende/ als in einem/ aus unbetrüglicher Erfahrung herfliessendem Commentario, über die von dergleichen Arbeit beschriebenen Sieben Bücher P. Anthonii Neri, von Florentz ... Christophori Merretti, M.D. & Societ. Reg. Brittann. Socii, (so aus den Ital. und Latein. beyde mit Fleiß ins Hochdeutsche übersetzt) ... ( - )
Cover ( - )
Frontispiece ([1])
Kupfertitel ([2])
Titelseite ([3])
Widmung ([4])
Vorrede ([6])
Das Register und Inhalt der Capitel ... ([9])
Einleitungs-Vorrede Anthonii Neri, an den Kunst-begierigen Leser (1)
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Erstes Buch / Von der Glasmacher-Kunst (9)
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Anderres Buch / von der Glasmacher-Kunst (69)
Das dritte Buch / von der Glasmacher-Kunst (88)
Das vierdte Buch / von der Glasmacher Kunst (102)
Das fünffte Buch / von der Glasmacher-Kunst (116)
Das sechste Buch / von der Glasmacher-Kunst (135)
Das siebende Buch (151)
Joh. Kunckels Sonderbahre Zugabe der Glas-Kunst (201)
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Christopher Merretti ... Anmerckungen über die Bücher Anthonii Neri ... (213)
Zum Beschluß folget allhier die Historia von dem Tropff- oder Thränden-Glas (320)
Ein Anhang Von den Glasmacher-Oefen ... (326)
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Sonst schreibet Herr Merrett von den Glasmacher-Instrumenten/ welche in Engelland im Gebrauch sind ... (336)
Johann Kunckels Nützliche und nöthige Erinnerungen über die gesammten Merettischen Anmerckungen (338)
Folget zum Beschluß dieses ersten Theils Meiner Glas-Kunst/ eine kurtze ... Manier/ wie man die besten Salze ... (347)
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Erklärung der Kupffer/ zum Laugen- und Saltz-machen (350 [i.e. 348])
Pars Secunda, Zweyter Theil ([1])
Geliebter und Curieuser Leser ([3])
Inhalt Register des erstes Buchs / Des andern Theils ... ( - )
Zum Ersten Vom Glas-brennen - Zum Dritten ... (1)
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Des andern Theils der vollständigen Glas-Kunst / zweytes Buch (49)
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Des zweyten Theils der vollständigen Glas-Kunst Drittes Buch ... (68)
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Anhang Der vollständigen Glas-Kunst Oder Sendbrieff/ an einen guten Freund (97)
Zum Beschluß folget Eine Erklärung und Register derer Oefen und aller anderer / zu dieses Wercks ersten und zweyten Theilen gehörigen Kupffer-Figuren. (135)
Register Über den ersten Theil der vollständigen Glasmacher-Kunst ( - )
Register. Über den andern Theil der vollständigen Glas-macher-Kunst. ([11])
An den scharffsichtigem Momum / Druck-Fehler im ersten Theil ([17])
Im andern Theil / Bericht an den Buchbinder .... ([17]
Alternative splice forms of CYLD mediate ubiquitination of SMAD7 to prevent TGFB signaling and promote colitis.
No full textBACKGROUND & AIMS: The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosus, and variants have been associated with Crohn disease (CD). Splice forms of CYLD that lack exons 7 and 8 regulate transcription factors and functions of immune cells. We examined the expression of splice forms of CYLD in colon tissues from patients with CD and their effects in mice. METHODS: We performed immunohistochemical analyses of colon tissues from patients with untreated CD and patients without inflammatory bowel diseases (controls). We obtained mice that expressed splice forms of CYLD (sCYLD mice) without or with SMAD7 (sCYLD/SMAD7 mice) from transgenes and CYLD-knockout mice (with or without transgenic expression of SMAD7) and performed endoscopic analyses. Colitis was induced in Rag1(-/-) mice by transfer of CD4(+) CD62L(+) T cells from C57/Bl6 or transgenic mice. T cells were isolated from mice and analyzed by flow cytometry and quantitative realtime polymerase chain reaction and intestinal tissues were analyzed by histology and immunohistochemistry. CYLD forms were expressed in mouse embryonic fibroblasts, primary T cells, and HEK293T cells, which were analyzed by immunoblot, mobility shift, and immunoprecipitation assays. RESULTS: The colonic lamina propria from patients with CD was infiltrated by T cells and had higher levels of sCYLD (but not full-length CYLD) and SMAD7 than tissues from controls. Incubation of mouse embryonic fibroblasts and T cells with transforming growth factor b increased their production of sCYLD and decreased full-length CYLD. Transgenic expression of sCYLD and SMAD7 in T cells prevented the differentiation of regulatory T cells and T-helper type 17 cells and increased the differentiation of T-helper type 1 cells. The same effects were observed in colon tissues from sCYLD/SMAD7 mice but not in those from CYLD-knockout SMAD7 mice. The sCYLD mice had significant increases in the numbers of T-helper type 1 cells and CD44high CD62Llow memory-effector CD4(+) T cells in the spleen and mesenteric lymph nodes compared with wild-type mice; sCYLD/SMAD7 mice had even larger increases. The sCYLD/ SMAD7 mice spontaneously developed severe colitis, with infiltration of the colon by dendritic cells, neutrophils, macrophages, and CD4(+) T cells and increased levels of Ifng, Il6, Il12a, Il23a, and Tnf mRNAs. Co-transfer of regulatory T cells from wild-type, but not from sCYLD/SMAD7, mice prevented the induction of colitis in Rag1(-/-) mice by CD4(+) T cells. We found increased levels of poly-ubiquitinated SMAD7 in sCYLD CD4(+)T cells. CYLD formed a nuclear complex with SMAD3, whereas sCYLD recruited SMAD7 to the nucleus, which inhibited the expression of genes regulated by SMAD3 and SMAD4. We found that sCYLD mediated lysine 63-linked ubiquitination of SMAD7. The sCYLD-SMAD7 complex inhibited transforming growth factor beta signaling in CD4(+)T cells. CONCLUSIONS: Levels of the spliced form of CYLD are increased in colon tissues from patients with CD. sCYLD mediates ubiquitination and nuclear translocation of SMAD7 and thereby decreases transforming growth factor beta signaling in T cells. This prevents immune regulatory mechanisms and leads to colitis in mice
First gamma-ray spectroscopy of Fe-49 and Ni-53: Isospin-breaking effects at large proton excess
No full textIsospin-breaking effects have been studied for the first time in T=3/2 isobaric analog states. Gamma decays have been observed from Tz=-3/2 nuclei, 49Fe and 53Ni, presented here in new level schemes, and mirror energy differences have been computed following observation of analog states in 49V and 53Mn, respectively. Shell-model calculations in the fp shell are in good agreement with the data and reveal the importance of non-Coulomb isospin-breaking effects in T=3/2 isobaric analog states. A two-step fragmentation process was developed to allow access to highly proton-rich nuclei and to produce each member of a mirror pair via mirrored fragmentation of a 56Ni secondary beam. This work represents the first study using this technique and demonstrates the power of this approach for future studies of isobaric analog states in very proton-rich systems
The immediate impact of the COVID-19 pandemic on motor neuron disease services and mortality in Scotland
No full textThe article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal and CARE-MND Consortium, was originally published online on 5 September 2020 with Open Access under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.</p
Testing the Structure of Exotic Nuclei via Coulomb Excitation of Radioactive Ion Beams at Intermediate Energies
No full textJohannis Kunckelii, churfürstl. Brandenb. würcklich bestallt-geheimden Cammer-Dieners, Ars vitraria experimentalis, oder, Vollkommene Glasmacher-Kunst : lehrende, als in einem ... commentario über die ... sieben Bücher P. Anthonii Neri von Florenz, und denen ... Anmerckungen Christophori Merretti ... (so aus den Ital. und Latein. beyde mit Fleiss ins Hochdeutsche übersetzt) die allerkurtz bundigsten Manieren, das reineste Chrystall-Glas, alle gefärbte oder tingirte Gläser, künstliche Edelstein oder Flüsse ... zu machen ... : sampt einem II. Haupt-Thiel, so in drey unterschiedenen Bücher und mehr als 200 Experimenten bestehet, darinnen vom Glasmahlen, Vergulden und Brennen ... Türckisch Pappier, [et]c. ... und viel andere ungemeine Sachen zu machen, gelehret werden : mit einem Anhange von denen Perlen und fast allen natürlichen Edelsteinen ...
No full textSignatures: [superscript pi][A]² [superscript pi]B⁴ [superscript pi](C)² A-2U⁴ 2X² 3A-3Z⁴.Page numbers 153-154 omitted.Frontispiece port. of Kunckel has legend: Luc. a Lhibenau Von Wehrd. This should probably be interpreted to mean that the port. was engraved after Lhibenau by von Wehrd, i.e. Nicolaus Häublin; see Thieme-Becker. Following the port. is an engraved allegorical added title leaf, with title: Ioh. Kunckeli Ars vitraria experimentalis. There are 20 leaves of engraved ill., 17 of them full-page, as well as in-text woodcuts. Head- and tail-pieces, ornamental initials.Pt. 2 has separate t.p.Two related issues appeared in the same year, both printed by Günther in Leipzig. The first has publisher statement: Auff Kosten des Autoris, bey Johann Bielcke, Buchführern in Jena. The imprint of the second is Amsterdam & Danzig, with the author and Bielcke as publishers.Mode of access: Internet.At head of title is ownership inscription of the Carmelites of Vienna. On back pastedown is 17-line inscription in German giving a recipe for varnish.Binding: vellum, lapped foredges, with remains of 2 pairs of ties. Title & author written at head of spine; below them, a large T.In Getty copy preliminary gathering (C)², the table of contents for Neri's Glas-Kunst, is bound after 2X2
Single-particle structure at N=29:The structure of Ar 47 and first spectroscopy of S 45
No full textComprehensive spectroscopy of the N=29 nucleus Ar47 is presented, based on two complementary direct reaction mechanisms: one-neutron pickup onto Ar46 projectiles and one-proton removal from the 1- ground state of K48. The results are compared with shell-model calculations that use the state-of-the-art SDPF-U and SDPF-MU effective interactions. Also, from the Be9(Cl46,S45+γ)X one-proton-removal reaction, we report the first γ-ray transitions observed from S45. By using comparisons with shell-model calculations, and from the observed intensities and energy sums, we propose a first tentative level scheme for S45
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