150 research outputs found
Wind-tunnel study of block 259 building, Houston
No full textCER78-79JEC-JAP-AK18.Prepared for Colaco Engineers, Inc.Includes bibliographical references (pages 32-33).January 1979
T gamma delta cells and their subsets in blood and synovial tissue from rheumatoid arthritis patients.
No full textA Monte Carlo Simulation Study on Adsorption of Nitrogen Oxides (NOx) in zeolites
No full textNitrogen oxides (NOx) are significant sources of air pollution. Nitrogen oxides like Nitric oxide (NO) and Nitrogen dioxide (NO2) are mainly responsible for the acid rain and smog. Nitrous oxide (N2O), also known as the laughing gas, is the major greenhouse gas that is responsible for the ozone layer's damage in the troposphere. According to the Environmental Protection Agency (EPA) report, one pound of N2O is 300 times more potent greenhouse gas than one pound of CO2. The significant emitters of Nitrogen oxides (NOx) are automobiles, agricultural sources, thermal power plants, and chemical processes like Nitric acid production plants, paint manufacturing, etc. This study mainly focuses on the tail gas emitted from the Nitric acid production facility. The tail gas emitted during the HNO3 production consists of almost 2% of O2, 200-400 ppm of NO2, and NO, whereas 800 ppm of N2O. As N2O is the most emitted gas from the Nitric acid production facility, it is followed by NO2 and NO, so it is essential to reduce these pollutants from the tail gas. Selective catalytic reduction (SCR) is a well-known technique currently involved in reducing NOx via the adsorption process from the Nitric acid production facility. But the costs involved in these methods are quite high. Nanoporous materials like zeolite exhibit uniform pore size and high thermal stability are said to be the promising adsorbents of NOx. The availability of a large number of zeolites makes it impossible to identify the proper zeolite for NOx adsorption experimentally. In such situations, molecular simulations are a powerful tool that can help identify the perfect zeolite. The time and cost involved in the process of molecular simulations are very low. In this work, Monte Carlo simulations involving reaction ensemble are implemented to obtain the equilibrium composition of NOx components at desired operating conditions in the Brick molecular simulation package. This is followed by Grand Canonical Monte Carlo simulations (GCMC) and Reactive Grand Canonical Monte Carlo simulations (RXMC-GCMC) for pure and quaternary NOx gas mixture adsorption in five different zeolites (FAU, FER, MOR, MFI, and TON) using simulation package RASPA. The composition results from the reaction ensemble are validated with the composition results obtained using the Gibbs minimization technique in the MATLAB model, and the results are in good agreement. The quaternary gas mixture adsorption results in five different frameworks from RXMC-GCMC simulations are then validated in Ideal adsorbed solution theory in the Python model, and the results are in good agreement at the given operating conditions. </p
A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?
No full textThe human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5′-phosphate- (PLP-) dependent cystathionine β-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S). CBS activity, contributing to cellular redox homeostasis, is positively regulated by S-adenosyl-L-methionine (AdoMet) but fully inhibited upon CO or NO• binding to a noncatalytic heme moiety. Despite extensive studies, the molecular basis of several pathogenic CBS mutations is not yet fully understood. Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels. The higher CO affinity could result from the slightly higher flexibility in the heme surroundings revealed by solving at 2.80-Å resolution the crystallographic structure of a truncated p.P49L. Additionally, we report that p.P49L displays impaired H2S-generating activity, fully rescued by PLP supplementation along the purification, despite a minor responsiveness to AdoMet. Altogether, the results highlight how increased propensity to CO inactivation of an otherwise WT-like variant may represent a novel pathogenic mechanism in classical homocystinuria
Primary epithelial-myoepithelial carcinoma of the pituitary gland
No full textPrimary salivary gland-like tumors of the sella are rare and often challenging to diagnose. They reportedly derive from serous and mucinous glands that remain trapped in the infundibulum during embryogenesis. We report a 68-year-old man who presented with partial left third cranial nerve palsy, visual loss in the left eye without visual field defects, headache, weight loss and reduced muscle bulk. Neuroimaging studies demonstrated a solid and cystic, avidly enhancing lesion expanding the pituitary fossa and extending to the left cavernous sinus. The patient underwent craniotomy and the tissue removed showed features of epithelial-myoepithelial carcinoma similar to the salivary gland, skin and breast counterpart. No primary tumor was found outside the sella. The lesion behaved aggressively despite radio-chemotherapy and the patient died 22 months from the onset. The tumor showed a novel TP53 in-frame deletion (Gly154del) while no variants were found in H-RAS hotspot regions (codons 12, 13 and 61). Our report expands the spectrum of salivary gland-like tumors primarily occurring in the sella and emphasizes the need for specialist review of rare, non-neuroendocrine tumors of the pituitary and sella regions
Investigating the relationship between perception of an organisation's ethical culture and worker motivation
No full text<p>The publisher's final version this work can be found at https://dx.doi.org/10.1108/IJOA-08-2018-1511. Deposited by openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright, however, if you think it does you can request a takedown by emailing [email protected].</p>
Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions
No full textAntibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic MuHV-4 replication. The reductions, even by neutralizing mAbs, were largely or completely dependent on host IgG Fc receptors. Therefore, passive antibody can blunt acute gamma-herpesvirus lytic infection, and does this principally by IgG Fc-dependent functions rather than by neutralization
Trinuclear Co<sup>II</sup>Ln<sup>III</sup>Co<sup>II</sup> Complexes (Ln = La, Ce, Nd, Sm, Gd, Dy, Er, and Yb) with 2,6-Dipicolinoylbis(<i>N</i>,<i>N</i>‑diethylthiourea): Synthesis, Structures, and Magnetism
No full textOne-pot reactions of 2,6-dipicolinoylbis(N,N-diethylthiourea) (H2L) with Co(CH3COO)2·4H2O and LnCl3, where Ln = La, Ce, Nd, Sm, Gd, Dy, Er, and Yb, in warm methanol
in the presence of Et3N, give stable trinuclear complexes
of the composition [LnCo2(L)2(μ1,3-OOCCH3)2X] (“CoLnCo” complexes),
where X– = κ2-CH3COO– or Cl–. X-ray structure determinations
reveal symmetric trinuclear complexes containing two organic ligands
(L2–), two terminal CoII ions, and one
central LnIII ion. The organic ligands coordinate equatorially
to the two CoII ions via two bidentate (O,S) N-acylthiourea moieties and tridentate to the central Ln ion via the
(O,N,O) 2,6-dipicolinoyl moieties. Two acetate bridges established
between each of the terminal Co and central Ln ions complete the square-pyramidal
coordination spheres of CoII. All products possess an additional
chlorido ligand axially coordinated to the lanthanide except the gadolinium(III)
and lanthanum(III) complexes, where bidentate acetato ligands are
coordinated. Fitting the χmT versus T data of the “CoLaCo” complex gives the axial
and rhombic zero-field-splitting parameters D = 24.3(4)
cm–1 and E = −1.0(2) cm–1, respectively, and anisotropic Landé values gx,y = 2.81(1)
and gz = 2.00 as well
as weak antiferromagnetic interactions between two high-spin CoII centers with J = −0.49(2) cm–1. The nature of the magnetic interactions between
the LnIII ions and the CoII ions in the “CoLnCo”
complexes is deduced by comparing their χMT values to the sum of χMT values of the analogous “CoLaCo” and related “ZnLnZn”
complexes. The “CoDyCo” complex reveals an antiferromagnetic
interaction, while the remaining “CoLnCo” complexes
show ferromagnetic interactions
Microdistribution of Faunal Assemblages at Deep-Sea Hydrothermal Vents in the Southern Ocean
No full textChemosynthetic primary production by microbes supports abundant faunal assemblages at deep-sea hydrothermal vents, with zonation of invertebrate species typically occurring along physico-chemical gradients. Recently discovered vent fields on the East Scotia Ridge (ESR) in the Southern Ocean represent a new province of vent biogeography, but the spatial dynamics of their distinct fauna have yet to be elucidated. This study determines patterns of faunal zonation, species associations, and relationships between faunal microdistribution and hydrothermal activity in a vent field at a depth of 2,400 m on the ESR. Remotely operated vehicle (ROV) dives obtained high-definition imagery of three chimney structures with varying levels of hydrothermal activity, and a mosaic image of >250 m2 of seafloor co-registered with temperature measurements. Analysis of faunal microdistribution within the mosaiced seafloor reveals a consistent pattern of faunal zonation with increasing distance from vent sources and peak temperatures. Assemblages closest to vent sources are visibly dominated by a new species of anomuran crab, Kiwa n. sp. (abundance >700 individuals m?2), followed by a peltospiroid gastropod (>1,500 individuals m?2), eolepadid barnacle (>1,500 individuals m?2), and carnivorous actinostolid anemone (>30 individuals m?2). Peripheral fauna are not dominated by a single taxon, but include predatory and scavenger taxa such as stichasterid seastars, pycnogonids and octopus. Variation in faunal microdistribution on chimneys with differing levels of activity suggests a possible successional sequence for vent fauna in this new biogeographic province. An increase in ?34S values of primary consumers with distance from vent sources, and variation in their ?13C values also indicate possible zonation of nutritional modes of the vent fauna. By using ROV videography to obtain a high-resolution representation of a vent environment over a greater extent than previous studies, these results provide a baseline for determining temporal change and investigations of processes structuring faunal assemblages at Southern Ocean vents
Aspects of approximate optimisation: overcoming the curse of dimensionality and design of experiments
No full textCoupling optimisation algorithms to Finite Element Methods (FEM) is a very promising way to achieve optimal metal forming processes. However, many optimisation algorithms exist and it is not clear which of these algorithms to use. This paper investigates the sensitivity of a Sequential Approximate Optimisation algorithm (SAO) proposed in [1-4] to an increasing number of design variables and compares it with two other algorithms: an Evolutionary Strategy (ES) and an Evolutionary version of the SAO (ESAO). In addition, it observes the influence of different Designs Of Experiments used with the SAO. It is concluded that the SAO is very capable and efficient and its combination with an ES is not beneficial. Moreover, the use of SAO with Fractional Factorial Design is the most efficient method, rather than Full Factorial Design as proposed in [1-4]
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