212 research outputs found
Elsa Morante e il cinema: "L’isola di Arturo" di Damiano Damiani
No full textAlthough its intensity and duration, the relation between Elsa Morante and the cinema is less studied by the critics, perhaps because of the scarceness of information. But the discovery of many new documents in these years permitted to know the plots written (but not realized9 by the Author from 1933 till 1952 (there are three different plots: Il diavolo, Miss Italia and Verranno a te sull’aure). It is also possible to have a clear idea of the collaboration with some directors like: Alberto Lattuada, Luchino Visconti, Franco Zeffirelli, Pier Paolo Pasolini. A close analysis of the cinematographic version of the novel L’Isola di Arturo, directed by Damiano Damiani in 1962, permits to determine that the dissatisfaction which Morante expressed in many circumstances derives from a lack of dialogue between her and the director damiano Damiani.Pure se intenso e continuato nel tempo, il rapporto tra Elsa Morante e il cinema è sempre rimasto un argomento poco sondato dalla critica, forse anche per la scarsità di informazioni al riguardo. Negli ultimi anni, tuttavia, molti nuovi documenti sono stati reperiti, e tali scoperte hanno reso possibile conoscere i soggetti cinematografici da lei scritti (ma mai realizzati) tra il 1939 e il 1952 (sono tre: Il diavolo, Miss Italia e Verranno a te sull’aure...), nonché farsi un’idea concreta delle sue varie collaborazioni con registi come Alberto Lattuada, Luchino Visconti, Franco Zeffirelli, Pier Paolo Pasolini. Differentemente, un’analisi attenta della trasposizione cinematografica de L’isola di Arturo, diretta da Damiano Damiani nel 1962, mostra come l’esibita insoddisfazione della scrittrice, espressa in più occasioni, nasca per l’appunto da un’assenza di dialogo tra i due artisti
[Pulmonary perfusion in children operated on for congenital diaphragmatic hernia]. FT Studio della perfusione polmonare in bambini operati di ernia diaframmatica congenita.
No full textImpact of hyporheic zones on nutrient dynamics
No full textRiverine sediments play a fundamental role within the fluvial system, since they represent potential removal zones of stream-borne pollutants and, in particular, nutrients derived by anthropogenic activities. The region of sediments where the exchange and mixing of surface and subsurface waters occurs is the hyporheic zone. This region is also a place of intense biogeochemical activity, influencing both the flora and the fauna living in the fluvial environment. In the last decades several works were focused either on the water exchanges or the biochemical reactions in the hyporheic zone but just few considered the interactions of both hydraulic and biochemical processes. In this thesis the reactive transport of oxygen and the most common water-borne nutrients (i.e., dissolved organic carbon, nitrate and ammonium) in a duned streambed is investigated. In particular, a numerical model is employed to simulate the flow field, the biogeochemical reactions and the solute spatial distribution in the hyporheic zone. Sensitivity analyses are also performed to study the influence of different hydrological and chemical properties of the system on the net solute fluxes across the streambed. Finally, the effect of sediment heterogeneity on substance reaction rates and, specifically, on nitrate source/sink role played by the sediments is also analyzed for a rippled streambe
Unconscious Racial Bias May Affect Dentists’ Clinical Decisions on Tooth Restorability:A Randomized Clinical Trial
No full textMethods: In this single-center cross-sectional survey, 57 dentists were given a clinical scenario in combination with a patient’s relevant clinical photographs and radiographs depicting either a Black or White patient presenting with a decayed tooth and associated symptoms of irreversible pulpitis. Explicit bias was measured through a questionnaire, which evaluated participants’ course of treatment, strength of recommendation, and their perception of patients’ dental cooperativeness. Implicit bias was evaluated through brief implicit associate tests. Results: Recommendation for root canal treatment (RCT) in the White patient condition was significantly higher than in the Black patient condition (χ2 = 4.77, P < 0.05). Overall, participants were significantly more likely to recommend root canal treatment to White patients (t = 2.46, P = 0.0172) and significantly more likely to recommend extraction for Black patients (t = 3.03, P = 0.0034). In total, 91.23% and 78.95% of all participants displayed high Brief Implicit Association Test race and cooperation scores, respectively, showing a pro-White bias in both categories. This trend was shown to be irrespective of the patient condition. Conclusions: Dentists’ decision making was affected by the race of the patient, resulting in a greater likelihood of extractions (less RCT) for Black patients presenting with a broken-down tooth and symptoms of irreversible pulpitis. Knowledge Transfer Statement: The results of this study can be used by clinicians to understand the impact that unconscious racial bias may have on their treatment planning decisions. This information can create awareness, thereby reducing the impact that potential biases can have on the treatment patients receive.</p
Unique association of non-functioning pheochromocytoma, ganglioneuroma, adrenal cortical adenoma, hepatic and vertebral hemangiomas in a patient with a new intronic variant in the VHL gene
No full textWe analyzed the clinical, hormonal, immunohistochemical and genetic features in a 69-yr-old Caucasian woman with a very rare "composite and mixed pheochromocytoma". This was characterized by right adrenal pheochromocytoma associated with homolateral ganglioneuroma and controlateral adrenal cortical adenoma. The three tumors, incidentally discovered, proved to be non-functioning (normal secretion of catecholamines and of other neuroendocrine peptides, glucocorticoids, mineralcorticoids and androgens). Accordingly, the patient showed no sign or symptom of endocrine disease. Computed tomography (CT) and magnetic resonance (MR) demonstrated a typical adenomatous lesion on the left adrenal gland with precocious uptake of the radiotracer on radioidine ( 131I)-norcholesterol adrenal scintigraphy, while the controlateral gland showed hyperdensity on CT, hyperintensity on MR and no uptake at adrenal scintigraphy. In addition, CT and MR revealed a vertebral and two hepatic hemangiomas. The right adrenal gland was surgically removed and, microscopically, pheochromocytoma and ganglioneuroma areas appeared intermixed without a predominant component. The former showed strong immunoreactivity for chromogranin, synaptophysin, vascular endothelial growth factor (VEGF) and CD34, while the latter appeared positive for neuron-specific enolase (NSE) and S-100. Peripheral blood genomic DNA analysis revealed a new intronic variant (5557A>G) in the von Hippel-Lindau gene (VHL) not observed in our control population
[Follow-up pulmonary scintigraphy of diaphragmatic hernias surgically treated at birth]. FT Follow-up scintigrafico polmonare delle ernie diaframmatiche operate alla nascita.
No full textHigh-resolution sample size enrichment of single-cell multi-modal low-throughput Patch-seq datasets
No full textSingle-cell multimodal technologies are becoming the hot topic of single-cell heterogeneity and function studies, promising to unravel the hidden relationship and functionalities of different aspects of the cells. Among the plethora of single-cell technologies, interesting is the patch-seq technology, which simultaneously performs Patch clamp measures and scRNA-seq on the same cells. However, given the experimental limitations of throughput of Patch clamp, the scRNA-seq analysis is challenging because it requires more samples to investigate cellular heterogeneity. Usually, the solution is associating the cells with the cell types in an existing scRNA-seq dataset. However, doing so loses part of the single cell resolution of the multimodal technique. Therefore, this work proposes a procedure leveraging the Seurat Integration process to find from a reference dataset t he most similar cells to the ones from the patch-seq. The similarity is how much gene expression profiles are identical, and to evaluate that, this work defines various etrics based on R and Index. In this way, one obtains a selection of suitable Reference cells to enrich the number of cells on which to perform multimodal investigation
Optimization of the sanitary management and impact on quality production in a new farrow-to-finish farm
No full textInfant ALL patients carrying t(4;11) have a different genotypic profile than older ALL children
No full textMice models and prenatal studies indicate that in childhood ALL the individual genetic lesions alone are insufficient to generate a full leukemic phenotype, and cooperating oncogenic lesions are required. Recently, multiple genome-wide studies on childhood ALL (1-18 years) identified deletions at several loci, mainly affecting genes that play a critical role in regulating B cell development and differentiation. By contrast, the prenatal and postnatal steps in the pathogenesis of Infant ALL (less than 1 year at diagnosis) are not defined. Infant ALL is a very aggressive disease, with t(4;11)/MLL-AF4 fusion representing the major subgroup. Although the very short latency period suggests that leukemogenic events occur prenatally, mice models indicates that MLL-AF4 alone is not sufficient to induce leukemia, and additional mutations may occur. Also unclear is whether the molecular pathways needed for lymphoid cell differentiation are altered in cases with an MLL rearrangement and, if so, whether these alterations differ between the leukemia of infants and older children. Aim of this study was to detect MLL-cooperating aberrations, undetectable by conventional techniques, by using genome-wide single nucleotide polymorphism (SNP) genome wide analysis (100K SNP human mapping, Affymetrix). More specifically, we searched for Loss of Heterozygosity (LOH) associated or not to copy number alteration. The identification of these lesions could help identifying leukemia pathogenesis, as well as providing the basis for targeted therapy. We have analyzed 28 cases of Infant ALL with t(4;11) at diagnosis and their corresponding samples at remission, when available (n=18). SNP data were analyzed by using dChip software, and confirmed by CNAG 2.0. A more dense SNP array analysis (250K) has been applied in selected cases to confirm LOH and precisely dissect the affected chromosomal regions. Compared to older childhood ALL patients, a far limited number of deletions/amplifications has been found; only 2/28 patients showed deletions, namely 1p36.33-p36.31 in 1 patient and 3p11.1-p12.2 plus 7q22.1-q22.2 in another patient, while 26/28 Infant ALL did not present any visible structural variation. Different from older children, several segmental copy-number neutral (CNN) LOH have been detected by dChip. The extension and prevalence of the affected regions was variable; among them 6p21.32 (4/28 cases), 7q31.33-q32.1 (3/28), 8q21.12-q21.3 (2/28), 8q24.11 (2/28) and 14q21.2 (2/28). Overall, these results confirm that Infant ALL with t(4;11)/MLL-AF4 fusion represents a biologically unique disease, different from other type of leukemia occurring in older children. While in older children a multistep mechanism (with the involvement of several genes) is required for the full leukemic phenotype, MLL rearrangements per se might play a major role on the leukemogenesis. By this approach it could not be excluded that different mechanisms could cooperate with MLL in transforming cells, including point mutations. The functional role of CNN-LOH still needs to be understood: they could either reflect the duplication of oncogenic mutations, or be related to epigenetic mechanisms
Constructing a frame of cube : connecting 3D shapes with direction, location and movement
No full textWith the advancement of new technologies, this author has in 2010 started to engineer an online learning environment for investigating the nature and development of spatial abilities, and the teaching and learning of geometry. This paper documents how this new digital learning environment can afford the opportunity to integrate the learning about 3D shapes with direction, location and movement, and how young children can mentally and visually construct virtual 3D shapes using movements in both egocentric and fixed frames of reference (FOR). Findings suggest that year 4 (aged 9) children can develop the capacity to construct a cube using egocentric FOR only, fixed FOR only or a combination of both FOR. However, these young participants were unable to articulate the effect of individual or combined FOR movements. Directions for future research are proposed
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