31,394 research outputs found
Portrait of Louis Nowra, author, 1981, 3 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728377
Portrait of Louis Nowra, author, 1981, 2 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728375
Portrait of Louis Nowra, author, 1981, 1 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728368
Portrait of Louis Nowra, author, in front of a tree, 1981 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728421
Portrait of Louis Nowra, author, leaning on a railing, 1981 [picture] /
No full textTitle devised by cataloguer from inscription.; Part of the collection: Portraits of Louis Nowra, author, 1981.; Inscriptions: "Louis Nowra 5/2/81, H de Berg"--In ink on verso of print.; Condition: Soiled, scratched.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4728382
A Chat with Author Thomas Berg
No full textJoin us for a chat between author Thomas Berg and law professors Stephanie Barclay, Rick Garnett and Sherif Girgis as they discuss Berg\u27s latest work. Notre Dame Law School\u27s Religious Liberty Initiative invites you to attend our event today at 12:30 p.m. in 1130 Eck Hall of Law, a book talk with Thomas Berg, author of Religious Liberty in a Polarized Age. Event Announcementhttps://scholarship.law.nd.edu/ndls_posters/1693/thumbnail.jp
A Chat with Author Thomas Berg
No full textJoin us for a chat between author Thomas Berg and law professors Stephanie Barclay, Rick Garnett and Sherif Girgis as they discuss Berg\u27s latest work. Notre Dame Law School\u27s Religious Liberty Initiative invites you to attend our event today at 12:30 p.m. in 1130 Eck Hall of Law, a book talk with Thomas Berg, author of Religious Liberty in a Polarized Age. Event Announcementhttps://scholarship.law.nd.edu/ndls_posters/1693/thumbnail.jp
Portrait of Mary Durack, author, 1976 [picture] /
No full textTitle devised by cataloguer from accompanying information.; "Durack, Mary; 12/3/1976, Photog by Hazel de Berg"--Compactus card.; Condition: Scratched, soiled.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4778087; Lent for copying
The times they are a-changing – A refined proposal for finite HBV nucleos(t)ide analogue therapy
No full textAlthough discontinuation of nucleos(t)ide analogue (NA) treatment before HBsAg loss is part of all current HBV treatment guidelines for HBeAg-positive patients who achieve HBeAg seroconversion, a treatment endpoint known to be associated with silencing of HBV transcriptional activity and restoration of HBV-specific immune control, whether it is even appropriate to consider NA discontinuation before HBsAg loss in the HBeAg-negative phase remains highly controversial. Despite the growing evidence that a relevant, albeit small, proportion of patients with HBeAg-negative disease can be cured by stopping NA treatment, the fear of discontinuation-associated relapse and the uncertainty of how to predict off-therapy response and monitor patients after discontinuation have generated scepticism and subsequently led to low implementation of this concept in the clinic. In this article, we propose a concept in which NA discontinuation-associated relapse is an integral part of the stop-to-cure approach and ultimately the trigger for achieving HBsAg loss. However, the relapse in this sense becomes functionally effective only if HBV-specific immune reinvigoration and silencing of HBV transcriptional activity have been achieved during the NA treatment period. The probability of functional cure and the severity of post-discontinuation flares depend on the underlying baseline transcriptional activity of HBV when NA therapy was started, as well as the duration of NA treatment, both factors that should be considered as we move towards individualised approaches to HBV cure
Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy
No full textThe interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit strong responses), but also polyspecificity (ligands with distinct physicochemical properties are capable of interacting with the TCR). Degeneracy does not gainsay the fact that TCR recognition is fundamentally specific: for the vast majority of ligands, the functional sensitivity of a given TCR is virtually null whereas this TCR has an appreciable functional sensitivity only for a minute fraction of all possible ligands. Degeneracy can be described mathematically as the probability that the functional sensitivity, of a given TCR to a randomly selected ligand, exceeds a set value. Variation of this value generates a statistical distribution that characterizes TCR degeneracy. This distribution can be modeled on the basis of a Gaussian distribution for the TCR/ligand dissociation energy. The kinetics of the TCR and the MHCI molecule can be used to transform this underlying Gaussian distribution into the observed distribution of functional sensitivity values. In the present paper, the model is extended by accounting explicitly for the kinetics of the interaction between the co-receptor and the MHCI molecule. We show that T-cells can modulate the level of degeneracy by varying the density of co-receptors on the cell surface. This could allow for an analog of avidity maturation during incipient T-cell responses
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