119 research outputs found
Computational methods for developing novel antiaging interventions
No full textAdvances in computational methodologies have ushered in innovations in visualization, calculations, and prediction of factors relating to aging processes and concomitant diseases with novel strategies like comparative genomics, protein interactive networks, and systems biology. Molecular level investigations of antiaging agents like phytochemicals such as curcumin, resveratrol, and quercetin have been carried out by electronic structure calculations by density functional theory and molecular docking studies to cytochrome P450 3A4 protein. It is found that both hydrogen bonding and hydrophobic interactions play a crucial role in the interaction between these phytochemicals and CY3A4 protein, which may provide important insights into modulations of drug metabolism in aging populations
Viability of GDP linked sovereign paper as replacement of sovereign debt: a shariah compatible risk sharing approach
No full textOver the past decades much effort and research has gone into establishing a viable set of Islamic financial institutions. An area of utmost importance, which still has gaping holes, is the development of instruments for government financing on a global level. Most developing countries including the bulk of Muslim nations, are heavily indebted with high reliance on multilateral financing primarily based on high interest rates. This vicious cycle of interest rates and debt have stunted the growth of these nations and worsened the conditions of the masses. This research brings to the forefront the concept of an equity in nature GDP linked paper, which allows for enhanced risk sharing based sovereign financing ..
Erythrocyte plasma membrane redox system in first degree relatives of type 2 diabetic patients
No full textAbstractDiabetes mellitus (TDM) is strongly associated with oxidative stress. Human erythrocytes contain a plasma membrane redox system (PMRS) which transfers electrons from intracellular donors (NADH, ascorbate) to extracellular acceptors outside the cell. We show that the activity of erythrocyte PMRS and AFR reductase becomes elevated in first degree relatives of type 2 diabetics and in TDM subjects. The increase in PMRS and AFR reductase signifies compensatory mechanisms to mitigate increased oxidative stress. These findings show that an impaired redox balance may be a cause the disturbance of homeostasis in type 2 diabetic families, even before the development of the disease
Traditional Indian Medicines Used for the Management of Diabetes Mellitus
No full textPlants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization, up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show antidiabetic potential. The present review is aimed at providing in-depth information about the antidiabetic potential and bioactive compounds present in Ficus religiosa, Pterocarpus marsupium, Gymnema sylvestre, Allium sativum, Eugenia jambolana, Momordica charantia, and Trigonella foenum-graecum. The review provides a starting point for future studies aimed at isolation, purification, and characterization of bioactive antidiabetic compounds present in these plants
Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity
Get PDFCurcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the yellow biphenolic pigment isolated from turmeric (Curcuma longa), has various medicinal benefits through antioxidation, anti-inflammation, cardiovascular protection, immunomodulation, enhancing of the apoptotic process, and antiangiogenic property. We explored the effects of curcumin in vitro (10−5 M to 10−8 M) and in vivo (340 and 170 mg/kg b.w., oral) on Na+/K+ ATPase (NKA), Na+/H+ exchanger (NHE) activity, and membrane lipid hydroperoxides (ROOH) in control and experimental oxidative stress erythrocytes of Wistar rats. As a result, we found that curcumin potently modulated the membrane transporters activity with protecting membrane lipids against hydro-peroxidation in control as well as oxidatively challenged erythrocytes evidenced by stimulation of NKA, downregulation of NHE, and reduction of ROOH in the membrane. The observed results corroborate membrane transporters activity with susceptibility of erythrocyte membrane towards oxidative damage. Results explain the protective mechanism of curcumin against oxidative stress mediated impairment in ions-transporters activity and health beneficial effects
The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia
No full textDiets rich in fats and cholesterol are mainly responsible for the production of free radicals which contribute to the incidence of hyperlipidemia and hypercholesterolemia. Both of these are the major factors responsible for CVDs. Hyperlipidemia is characterized by elevated level of total cholesterol (TC), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), and reduced level of high-density lipoprotein (HDL) in serum. The main role of diet is to provide ample amount of nutrients to meet the nutritional requirements of an individual. However, there are increasing scientific approaches helping the hypothesis that some food ingredients have beneficial effects over and above the provision of the basic nutrients. So in this chapter, the main focus is food categorized under nutraceutical and functional food and their various protective roles in the case of hyperlipidemia.</jats:p
Phytochemical Principles in the Traditional Indian System of Medicine used for the Management of Metabolic Syndrome
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