489 research outputs found
Plummer, S J G Sydney, QX17755
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/411074Surname: PLUMMER. Given Name(s) or Initials: S J G SYDNEY. Military Service Number or Last Known Location: QX17755. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 41460.226787
Item: [2016.0049.43340] "Plummer, S J G Sydney, QX17755
Cameron McRae Plummer book list, W.0087
No full textAbstract: Contains a list of books compiled by Haunted House Book Shop owner Cameron McRae Plummer.Scope and Content Note: The collection contains one notebook with a record of books (listed alphabetically by author and by title), including information about book prices and publishers, compiled by Cameron McRae Plummer. The list also includes information about book scarcity. A few postcards and letters are also inserted in the book. The back of the notebook contains a small number of miscellaneous notes dated between 1950 and 1961; these notations mostly document the interests of individual collectors.It is not clear if this is an actual inventory of books sold at The Haunted House Book Shop, which Plummer co-founded with Adelaide Trigg, or if is a list of books to be purchased for the shop or for a specific customer.Biographical/Historical Note: The son of Episcopal minister James Fitts Plummer and Jannie Minor, Cameron McRae Plummer was born on June 2, 1904, in West Virginia. The family moved to Mobile, Alabama, in 1916, where James Plummer served as the rector of All Saints' Episcopal Church. On August 29, 1944, Cameron Plummer married Mary Frances Young.Plummer became a successful bookseller in Mobile. City directories list him as the president of the Plummer-Marston Book Company. In 1941, Plummer and business partner Adelaine Trigg founded the Haunted Book Shop, a bookstore located in downtown Mobile. The bookstore was a Mobile landmark for fifty years, closing its doors in 1991. Plummer died on February 19, 1968, in Mobile
The view of the South Nave, (from the Dome) of the interior of the Garden Palace ; [picture] looking south from the dome, shows the exhibits of the New South Wales Department of Mines, the Dutch and Austrian Courts, etc. /
No full textThe South Nave, (from the Dome) The interior of the Garden Palace is not less effective or impressive in appearance than is the exterior. From north to south it measures 700 ft., and from east to west 400 feet, the avenues of the naves and transepts being 50 feet wide. Running round the naves and transepts are spacious galleries, 25 feet in width; the total amount of space in the entire structure being equal to 11,104,000 cubic feet. The view of the South Nave, looking south from the dome, shows the exhibits of the New South Wales Department of Mines, the Dutch and Austrian Courts, etc. --Printed on facing page.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an10697085-12
Early presynaptic and late postsynaptic components contribute independently to Brain-Derived Neurotrophic Factor-induced synaptic plasticity
No full textTrophin-induced synaptic plasticity consists of both presynaptic and postsynaptic processes. The potential interdependence of these mechanisms and their temporal relationships are undefined. The synaptic vesicle protein Rab3A is required for the early, initial 10 min phase, but not for the later phase of BDNF-enhanced transmission. We now examine the temporal distinction and mechanistic relationships between these phases of BDNF action. Rab3A mutant cells did not exhibit increased mEPSC frequency in response to BDNF in cell culture, indicating absence of the presynaptic component. In contrast, BDNF enhanced post-synaptic glutamate-induced current in the mutant neurons as in the wildtype, indicating that the postsynaptic component of the response was intact. Finally, the postsynaptic NMDA receptor subunit NR2B was phosphorylated at Tyr1472 by BDNF in Rab3A knockouts, as previously shown in wildtype. Our results are the first to demonstrate that presynaptic and postsynaptic components of BDNF-enhanced synaptic activity are independent and temporally distinct.Peer reviewe
Modern Homosexualities: Fragments of Lesbian and Gay Experiences
No full textThis book of nineteen original essays by activists and academics documents and analyses the dramatic changes in lesbian and gay experience over the last twenty years. It charts the growth of lesbian and gay studies, and examines key issues around communitites, identities, relationships, sexualities and politics. These essays, edited by a leading author in the field, herald a new confidence and maturity for the growing field of lesbian and gay studies
Economic Development in China and Its Implications for East Asia
No full textEconomic development in China, East Asia, trade adjustment
On the physical aspects that control mechanical deformation in bulk metallic glasses
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels
No full textBrain-derived neurotrophic factor (BDNF) modulates synaptic strength in hippocampal neurons, in addition to promoting survival and differentiation. To identify genes involved in trophic regulation of synaptic plasticity, we have used a multidisciplinary approach of differential display and family-specific slot blots in combination with whole-cell patch-clamp recordings of dissociated hippocampal neurons. Three hour exposure to BDNF elicited a 2.6-fold increase in synaptic charge and a concomitant induction of 11 genes as revealed by differential display, including the small GTP-binding vesicular trafficking protein Rab3A and the enzymeguanylate cyclase (GC). Slot blot analysis on a population of neurons confirmed an average of 3.1-fold induction of these clones. In contrast, individual pyramidal-like neurons that were first characterized electrophysiologically in the presence of BDNF and subjected to transcriptional analysis displayed more robust increases (4.8-fold), emphasizing the neuronal heterogeneity. Transcriptional changes of Rab3A and GC were accompanied by translational regulation, shown by Western blot analysis. Furthermore, a number of GC-associated and Rab3A effector molecules were induced by BDNF at either the gene or protein levels. The functional role of Rab3A in BDNF-induced synaptic plasticity was assessed using cells derived from Rab3A knock-out mice. These neurons failed to show an increase in synaptic charge in response to BDNF at 10 min; however a late response to BDNF was detected at 20 min. This late response was similar in time course to that induced by postsynaptic activation of glutamate receptors. Our results demonstrate a requirement for Rab3A and may reveal a temporal distinction between presynaptic and postsynaptic mechanisms of BDNF-induced synaptic plasticity associated with learning and memory.Peer reviewe
Therapeutic effectiveness of sensory deprivation in a clinical setting : Lynette S. Plummer
No full textBrain-Derived Neurotrophic Factor-Induced Gene Expression Reveals Novel Actions of VGF in Hippocampal Synaptic Plasticity
No full textSynaptic strengthening induced by brain-derived neurotrophic factor (BDNF) is associated with learning and is coupled to transcriptional activation. However, identification of the spectrum of genes associated with BDNF-induced synaptic plasticity and the correlation of expression with learning paradigms in vivo has not yet been studied. Transcriptional analysis of BDNF-induced synaptic strengthening in cultured hippocampal neurons revealed increased expression of the immediate early genes (IEGs), c-fos, early growth response gene 1 (EGR1), activity-regulated cytoskeletal-associated protein (Arc) at 20 min, and the secreted peptide VGF (non-acronymic) protein precursor at 3 hr. The induced genes served as prototypes to decipher mechanisms of both BDNF-induced transcription and plasticity. BDNF-mediated gene expression was tyrosine kinase B and mitogen-activated protein kinase-dependent, as demonstrated by pharmacological studies. Single-cell transcriptional analysis of Arc after whole-cell patch-clamp recordings indicated that increased gene expression correlated with enhancement of synaptic transmission by BDNF. Increased expression in vitro predicted elevations in vivo: VGF and the IEGs increased after trace eyeblink conditioning, a hippocampal-dependent learning paradigm. VGF protein was also upregulated by BDNF treatment and was expressed in a punctate manner in dissociated hippocampal neurons. Collectively, these findings suggested that the VGF neuropeptides may regulate synaptic function. We found a novel function for VGF by applying VGF peptides to neurons. C-terminal VGF peptides acutely increased synaptic charge in a dose-dependent manner, whereas N-terminal peptide had no effect. These observations indicate that gene profiling in vitro can reveal new mechanisms of synaptic strengthening associated with learning and memory.Peer reviewe
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