225 research outputs found
Modelling of oxygen diffusion in cork
No full textThe primary objective of this project is to better understand gas diffusion through natural cork structures by comparing simulations of gas diffusion through natural cork to experimental measurements of oxygen gas diffusion through the same structure. The cork\u27s internal structure is measured using x-ray computed tomography (CT). From the measured internal structure, a simple mapping is assumed converting the measured x-ray computed tomography images into a 3D map of local diffusion coefficient. Specifically, it is assured that the x-ray CT pixel value is inversely proportional to the diffusion coefficient of oxygen through the cork. A diffusion model for the cork structure was developed using finite commercial finite element method simulation software and the necessary boundary conditions. The primary intention is to create model which can help in understanding the ingress of oxygen through cork. By comparing simulation and experimental results, the role of the cork\u27s internal structure in gas diffusion can be better understood
Granulosa cell tumor of testis: Clinicopathological correlation of a rare tumor
No full textBackground: Granulosa cell tumor of testis is a rare tumor accounting for less than 4% of adult testicular tumors though they account for nearly 30% of childhood testicular tumors. Due to the rarity of these tumors, exact etiology, pathogenesis, prognostic factors and best treatment approach are not well known. The molecular events in pathogenesis of these stromal tumors have begun to unravel and these developments put forth a reasonable and scientific explanation for the association of these tumors with developmental anomalies like undescended testis. However, many questions remain unanswered. Materials and Methods: We performed a retrospective analysis of clinicopathological features of all Granulosa Cell Tumors of testis from our archives in addition to an extensive literature search using PUBMED with the key words "Granulosa Cell Tumor, testis". Results: We found six cases in our archives, two of which were of juvenile type and four of adult type. One out of these six cases presented with metastases. All cases underwent radical orchidectomy. Morphology and immunohistochemistry were classical in all cases and there was no diagnostic dilemma. Literature search revealed 63 cases of testicular Granulosa Cell Tumor in addition to highlighting the similarities in the biology and the dissimilarities in the clinical behavior as compared to ovarian Granulosa Cell Tumor. Conclusion: Testicular Granulosa Cell Tumor is a rare tumor, which although histologically similar to its ovarian counterpart, differs in clinical behavior. Further detailed investigations are needed to reveal the mystery behind the differing clinical behavior despite histological and immunohistochemical similarity between the testicular and ovarian Granulosa Cell Tumors
Mind the Gap
No full textThe bookchapter engages with the lack of continuity existing between different people’s experiences, and how it may be acknowledged in ethnographic forms of representation involving montage. My discussion was triggered by a concern, which author Daniel Mendelsohn has encapsulated thus: “It has become a cliché in modern culture that you can recreate other people’s experience. I’m very suspicious of that kind of simulacra” (Tetzlaff 2012: 8).i Mendelsohn’s suspicion resonates with historian James Clifford’s discussions about “ethnographic authority,” in which he noted that “it becomes necessary to conceive of ethnography not as the experience and interpretation of a circumscribed ‘other’ reality, but rather as a constructive negotiation involvingat least two, and usually more, conscious, politically significant subjects. Paradigms ofexperience and interpretation are yielding to discursive paradigms of dialogue and polyphony” (1988: 41). In my discussion, I infer that a certain use of montage may fit into such polyphonic discursive paradigms.The bookchapter engages with the lack of continuity existing between different people’s experiences, and how it may be acknowledged in ethnographic forms of representation involving montage. My discussion was triggered by a concern, which author Daniel Mendelsohn has encapsulated thus: “It has become a cliché in modern culture that you can recreate other people’s experience. I’m very suspicious of that kind of simulacra” (Tetzlaff 2012: 8). Mendelsohn’s suspicion resonates with historian James Clifford’s discussions about “ethnographic authority,” in which he noted that “it becomes necessary to conceive of ethnography not as the experience and interpretation of a circumscribed ‘other’ reality, but rather as a constructive negotiation involving at least two, and usually more, conscious, politically significant subjects. Paradigms of experience and interpretation are yielding to discursive paradigms of dialogue and polyphony” (1988: 41). In my discussion, I unfold how a certain use of montage may fit into such polyphonic discursive paradigms
Scream at the Librarian 1
No full textDesign by Amy Mees & Mark Wagner. Silkscreen by Kayrock Studio. Binding by Sara Parkel & Cat Glennon. Issued in custom phase box. Signed by the author and illustrators. Library copy is 33/50. Wilkinson Estate Endowment.https://digitalcommons.chapman.edu/screamatthelibrarian/1000/thumbnail.jp
Scream at the Librarian 3
No full textDesign by Amy Mees & Mark Wagner. Silkscreen by Kayrock Studio. Binding by Sara Parkel & Cat Glennon. Issued in custom phase box. Signed by the author and illustrators. Library copy is 33/50. Wilkinson Estate Endowment.https://digitalcommons.chapman.edu/screamatthelibrarian/1002/thumbnail.jp
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
No full textHeavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have nodular glomerulosclerosis on renal biopsy which on immunofluorescence and electron microscopy confirmed HCDD of immunoglobulin G1 type without any light-chain deposition. We also present an in-depth literature review on HCDD
Light Chain Proximal Tubulopathy Without Crystals in a Case of Burkitt Lymphoma Presenting With Acute Kidney Injury
No full textSerendipitous actinomycosis infection mimicking malignant lesion in carcinoma of unknown primary
No full textActinomycosis is a bacterial infection caused by Actinomyces species that are commensal in the human oral cavity, digestive tract, and genital tract. The present case highlights actinomycosis of the hypopharynx, mimicking malignancy in 18F-fluorodeoxyglucose positron emission tomography-computed tomography
Primary IgA nephropathy in north India: is it different?
No full textAbstract
Background
Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide, but has a variable geographic distribution. The bulk of the disease burden is borne by Asian countries. However, its exact prevalence or clinicopathologic spectrum in India is not well documented.
Methods
This cross sectional study analysed the renal biopsy findings and clinical features at presentation in 66 patients of primary IgA nephropathy diagnosed over a period of 2 years (2007–2008). The results were compared with studies from other centres in the country and elsewhere.
Results
IgA nephropathy comprised 8.1% of all native kidney biopsies. The mean age of the patients was 29.9 years with a male:female ratio of 4.4:1. Most patients presented with renal failure and a significant percentage (23%) also had nephrotic range proteinuria. Renal biopsies were classified by the Haas classification and were further scored by the MEST scoring system of the Oxford classification. By Haas classification, 41 cases (62%) showed advanced sclerotic lesions of class V. Active crescents (cellular or fibrocellular) were seen in 42% of cases, and 26% of cases showed endocapillary proliferation. Serum creatinine values were highest in the presence of proliferative lesions. MEST scoring of the Oxford classification was not applicable in approximately 18% of cases because of the presence of advanced sclerotic lesions. On immunofluorescence, the majority of the cases showed both mesangial and membranous positivity for IgA antisera. Electron microscopy revealed para-mesangial location of immune complex deposition in the majority of the cases. It also showed glomerular basement membrane abnormalities in two cases.
Conclusion
Comparison of clinical and pathological features revealed that this disease presents as an advanced disease in much younger individuals in this study compared to other studies. Elucidation of the underlying factors may have immense therapeutic implications.
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