195 research outputs found
Effect of Yakae-Prajamduen-Jamod Traditional Thai Remedy on Cognitive Impairment in an Ovariectomized Mouse Model and Its Mechanism of Action
No full textCognitive impairment is a neurological symptom caused by reduced estrogen levels in menopausal women. The Thai traditional medicine, Yakae-Prajamduen-Jamod (YPJ), is a formula consisting of 23 medicinal herbs and has long been used to treat menopausal symptoms in Thailand. In the present study, we investigated the effects of YPJ on cognitive deficits and its underlying mechanisms of action in ovariectomized (OVX) mice, an animal model of menopause. OVX mice showed cognitive deficits in the Y-maze, the novel object recognition test, and the Morris water maze. The serum corticosterone (CORT) level was significantly increased in OVX mice. Superoxide dismutase and catalase activities were reduced, while the mRNA expression of IL-1β, IL-6, and TNF-α inflammatory cytokines were up-regulated in the frontal cortex and hippocampus of OVX mice. These alterations were attenuated by daily treatment with either YPJ or 17β-estradiol. HPLC analysis revealed that YPJ contained antioxidant and phytoestrogen constituents including gallic acid, myricetin, quercetin, luteolin, genistein, and coumestrol. These results suggest that YPJ exerts its ameliorative effects on OVX-induced cognitive deficits in part by mitigating HPA axis overactivation, neuroinflammation, and oxidative brain damage. Therefore, YPJ may be a novel alternative therapeutic medicine suitable for the treatment of cognitive deficits during the menopausal transition
Application of NMR metabolomics in understanding the pjysiological target of Kampo medicine
No full textOther和漢医薬学総合研究所年報, 第44巻, 2018.03.31, Page153-15
Carrier Collaborative Networks: Hybrid Hub Location Algorithms
No full textWithin the context of the Logistics and supply chain and management, the Hybrid Hub and Spoke system has certain complexities regarding the selection of the hub location in the supply chain facility system. The performance and efficiency of the network route selection and hub location depends upon the percentage savings that has been made by choosing the appropriate location for the hub to maintain the efficient flow of the goods within the network. Hub location selection mostly depends on the profit margins shared by the carrier, supply and demand status of the facility and amount of flow of the goods through the facilities. This research develops a mathematical model using Centralized Carrier Collaborative and Multi-Hub Location Problem. The model encompasses various cost like costs of transportation for Direct Transport and Collaborative Transport, cost related to loading, unloading and operations, holding costs and maintenance cost, these are incorporated in taking decision for locating hub within a set of nodes/facilities. A Genetic algorithm meta-heuristic is used to solve the large size problems. The solution obtained using this meta-heuristics are compared with solution obtained from using Lagrangian Relaxation approach. An experimental study evaluates the sensitivity of the problem and analyses the hub location behavior of the problem by varying the profit margins and level of willingness of the carriers to collaborate subject to the percentage saving made
Ancistrolikokines E-H and related 5,8-coupled naphthylisoquinoline alkaloids from the Congolese liana with antiausterity activities against PANC-1 human pancreatic cancer cells
No full textA striking feature of the metabolite profile of (Ancistrocladaceae) is the exclusive production of 5,8-linked naphthylisoquinoline alkaloids varying in their OMe/OH substitution patterns and in the hydrogenation degree in their isoquinoline portions. Here we present nine new compounds of this coupling type isolated from the twigs of this remarkable Central African liana. Three of them, the ancistrolikokines E (9), E (10), and F (11), are the first 5,8-linked naphthyldihydroisoquinolines found in nature with -configuration at C-3. The fourth new metabolite, ancistrolikokine G (12), is so far the only representative of the 5,8-coupling type that belongs to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion. Moreover, five new -methylated naphthyltetrahydroisoquinolines, named ancistrolikokines A (13), A (14), C (5), H (15), and H (16) are presented, along with six known 5,8-linked alkaloids, previously identified in related African species, now found for the first time in . The structural elucidation was achieved by spectroscopic analysis (HRESIMS, 1D and 2D NMR) and by chemical (oxidative degradation) and chiroptical (electronic circular dichroism) methods. The new ancistrolikokines showed moderate to good preferential cytotoxic activities towards pancreatic PANC-1 cells in nutrient-deprived medium (NDM), without causing toxicity under normal, nutrient-rich conditions, with ancistrolikokine H (16) being the most potent compound
Scaling Up Soft Robotics: A Meter-Scale, Modular, and Reconfigurable Soft Robotic System
No full textToday's use of large-scale industrial robots is enabling extraordinary achievement on the assembly line, but these robots remain isolated from the humans on the factory floor because they are very powerful, and thus dangerous to be around. In contrast, the soft robotics research community has proposed soft robots that are safe for human environments. The current state of the art enables the creation of small-scale soft robotic devices. In this article we address the gap between small-scale soft robots and the need for human-sized safe robots by introducing a new soft robotic module and multiple human-scale robot configurations based on this module. We tackle large-scale soft robots by presenting a modular and reconfigurable soft robotic platform that can be used to build fully functional and untethered meter-scale soft robots. These findings indicate that a new wave of human-scale soft robots can be an alternative to classic rigid-bodied robots in tasks and environments where humans and machines can work side by side with capabilities that include, but are not limited to, autonomous legged locomotion and grasping.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this workLearning & Autonomous Contro
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