8,212 research outputs found
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
author
No full textauthorIn other places [Old Joe, the trapper] pointed out otter (or, as he pronounced it, "author") slidesPRINTED ITEM G.M.Story April 1959Not UsedNot UsedWithdrawn[see 'otter']Checked by Jordyn Hughes on Thu 09 Jun 201
Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang
No full textWong, Chai Kwok = 加入聚合物對均勻湍流及均勻湍流對流的影響 / 黃濟國.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 89-91).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Wong, Chai Kwok = Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang / Huang Jiguo
Author Correction: Manipulating anion intercalation enables a high-voltage aqueous dual ion battery
No full textThe original version of this Article did not acknowledge Prof. Jun Fan as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.link_to_subscribed_fulltex
Author Correction: A proteomic landscape of diffuse-type gastric cancer
No full textThe original version of this Article contained an error in the email address of the corresponding author Jun Qin. The correct email is [email protected]. The error has been corrected in the HTML and PDF versions of the Article.</jats:p
Corrigendum: The taeniaticornis-group of genus Apanteles Foerster (Hymenoptera, Braconidae, Microgastrinae) from China with one new species. Journal of Hymenoptera Research 96: 21–31. doi: 10.3897/jhr.96.99649
No full textIn a paper about a new species of Apanteles (Microgastrinae)(Liu & Chen, 2023), we regret the omission of one author Jun-hua Chen in the second place of the author list who did great job in construction of the ZJUH collection for this study and the mistake in institution order and corresponding author. We provide the correct information below.Zhen Liu1, 2, Jun-hua He1, Xue-xin Chen11 Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China. 2 Zoology Key Laboratory of Hunan Higher Education, College of Life and Environmental Sciences, Hunan University of Arts and Science, Changde 415000, China
Yong yu you hua zhi bei chao leng yuan zi hun he wu de guang xue ou ji jing
No full textChen, Jun = 用於優化製備超冷原子混合物的光學偶極阱 / 陳軍.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 109-117).Abstracts also in Chinese.Title from PDF title page (viewed on 29, November, 2016).Chen, Jun = Yong yu you hua zhi bei chao leng yuan zi hun he wu de guang xue ou ji jing / Chen Jun
A PORTRAITURE OF DOMESTIC SLAVERY IN THE UNITED STATES
No full textA Portraiture of Domestic Slavery, in the Unite~ States: with
reflections on the practicability of restoring the moral rights of the
Slave, without impairing the legal privileges of the possessor; and a
Project of a Colonial ARJlum for Free Pcrsons of Colour: inclUding
Memoirs of Facts on the interior Tmffie iB Slaves, and on IidBapping.
Illustrated with Engravings. By Jesse Torrey, jun. Physician.
Author of a Series of Essays on Morals aDd the Diffusion of Knowledge.
On the Possession of Truth in Fiction: A.S. Byatt's Confrontation with the Role of the Author
No full textWhen Possession’s protagonist, a post-structuralist/deconstructionist scholar named Roland Michell, finds and takes drafts of a letter written by Victorian poet Randolph Henry Ash, A.S. Byatt re-opens the longstanding debate concerning the ownership of truth and an author’s role in textual interpretation, ultimately asking: Who owns the meaning of a text? And even more so, why? The act of theft from the private world of an author (and the journey it spurs) allows Possession to coincide with pre-formalist notions about the author—that the author and their life is central to the meaning of their work—despite a dominant knowledge of formalism, new criticism, structuralism, poststructuralism, and deconstruction in the contemporary timeline. However, Possession’s three-and-a-half-page postscript chapter unravels a novel-length endorsement of pre-formalist notions, affording the novel a neutral existence that does not condemn nor encourage reliance on the biography of the author. As a result, this essay finds that the novel acts as a means for readers to identify two fundamental ideas about authorship and to witness a regressive transition from a post- to pre-formalist literary approach. In fact, by depicting the common occurrence of exchange to curate an author’s belongings (despite their passing), Possession even suggests that the reconfiguration of the author is a response to capitalist commodification. And so, by utilizing the theories of Roland Barthes and Michel Foucault, this essay argues how Possession shows the role of capitalism and consumerism in the contemporary approach to literature
Strait talk: United States-Taiwan relations and the crisis with China
No full texthttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290964500020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701HistoryA&HCI0BOOK REVIEW2288-2891
- …
