200 research outputs found
A Novel Attracting-Law based Digital Control Strategy with Improved Convergence Rate and Steady-State Error
No full text
Occlusal hypofunction affects the gene expression of osteoblast and primary cilia in the alveolar bone: An experimental study
No full text[Objective:] To investigate whether the gene expression changes of the primary cilia and osteoblast in the alveolar bone are associated with occlusal hypofunction. [Methods:] The unloading model was established in the right mandible on 6-week-old wild type (WT) male mice and the left side was used as a self-control study. Samples were sacrificed 2 weeks after the operation, and the parameters of alveolar bone were scanned and analyzed by micro-CT. The changes in the number and position of osteoblasts and osteoclasts were observed histologically, and real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of osteoblastogenesis and osteoclastogenesis. The changes in the number and location of primary cilia were observed by co-staining, and the expression of cilium-related genes was detected. The Pearson correlation analysis was used to detect the expression of cilium-related genes and osteoblastogenesis, and the colocalization was observed by co-staining. [Results:] Analysis of the unloading side revealed a significant decrease in bone volume/total volume (BV/TV) (P<0.05). The number of osteoblasts decreased while the number of osteoclasts increased significantly (P<0.01). Both the occurrence rate of primary cilia and expression of cilium-related genes showed a decreasing trend (P<0.05). Furthermore, the expression of osteoblastogenesis and intraflagellar transport genes were significantly correlated (P<0.05). Co-staining results showed that osteoblasts were located on the top of root furcation, and there were primary cilia on the surface. [Conclusion:] The parameters of alveolar bone on the experimental side were significantly decreased and bone resorption accelerated on the unloading side. Both the number of osteoblasts and primary cilia as well as the expression of related genes decreased significantly and the expression levels of related genes were positively correlated
Smart protective coatings with self‐sensing and active corrosion protection dual functionality from pH-sensitive calcium carbonate microcontainers
No full textHerein, we report the development of a self-sensing and active corrosion protection coating which incorporates pH-sensitive multilayer chitosan/alginate-covered CaCO3 microcontainers containing 1,10-phenanthrolin-5-amine (APhen). The microcontainers can respond to pH variation to release APhen which serves not only as a corrosion indicator but also as an inhibitor. An epoxy coating doped with 5 wt% microcontainers exhibited improved corrosion performance and was capable of inhibiting corrosion spreading from the damaged area in a 3.5 wt% NaCl solution. The salt spray test showed that corrosion damage can be quickly detected by the appearance of a red color within 2 min.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
Numerical modelling of hygrothermal stresses in composite building facades
No full textMany facade failures are probably caused, to a greater or less extent, by hygrothermal stresses due to thermal and moisture loads[29][33]. So far most studies on facade performance have considered the impacts of these two loads separately. However, heat and moisture transfer are two interrelated processes, and their synergistic impact on the facade performance may be of great importance. The author has developed a two-dimensional model for composite building facades, which can carry out transient analyses on both the simultaneous heat and moisture transfer and the induced stress distributions in the facades. The hygrothermal analysis is based on the linear Luikov's system of equations governing coupled heat and mass transfer in porous bodies. Both finite difference and finite element methods were used to numerically solve the mathematical model.Master of Engineering (CSE
Coupling Short-Circuit Ratio Calculation Method Based on the Source Network Load Correlation Thevenin Equivalent
No full textThe short-circuit ratio is a key index used to measure the voltage support capability of new energy grid-connected systems, which contradicts its accuracy and practicability. The current short-circuit ratio index (SCR-U) does not consider the influence of the coupling impedance between power supply and load on the short-circuit ratio in the calculation process. This paper derives the coupled short-circuit ratio (SCR-O) based on SCR-U and the coupled equivalent impedance. The coupled critical short-circuit ratio (CSCR-O) is then numerically obtained based on the maximum transmission power, and the extreme value of the critical short-circuit ratio is calculated to provide a numerical basis to determine the accuracy of SCR-U and SCR-O. Finally, simulations demonstrate the superiority of the coupling short circuit to the short-circuit ratio index. It can provide more accurate results and reflect the system’s real-time voltage stability
Data-driven corrosion inhibition efficiency prediction model incorporating 2D–3D molecular graphs and inhibitor concentration
No full textFollowing the construction of a dataset of cross-category corrosion inhibitors at different concentrations based on 1241 data from 184 research papers, a performance prediction model incorporating 2D–3D molecular graph representation and corrosion inhibitor concentration information was established. This model was shown to effectively predict the inhibition efficiency (IE) of different categories of corrosion inhibitors for carbon steel in 1 mol/L HCl solution. The model was also able to predict IEs of corrosion inhibitors at different concentrations. The results demonstrated that 3D features of corrosion inhibitors, especially those of large molecules, had a significant impact on the prediction precision of IEs.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
Long-term deterioration of lubricant-infused nanoporous anodic aluminium oxide surface immersed in NaCl solution
No full textThis study investigated the deterioration of a lubricant-infused anodic aluminium oxide surface in a 1 M NaCl solution for ∼200 days. Direct observation by cryo-SEM and quantitative analyses by UV spectroscopy and EIS revealed that the long-term deterioration of the lubricant-infused surface was divided into two stages: the surface-adhered lubricant layer gradually dissolved at a constant rate until the substrate was exposed; afterwards the lubricant infused in the nanochannels began to diffuse and was depleted after ∼200 days. The EIS results also revealed that the defects reduced the corrosion resistance of the lubricant-infused surface considerably.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
Cross-category prediction of corrosion inhibitor performance based on molecular graph structures via a three-level message passing neural network model
No full textCurrent experimental verification, computational modeling, and machine learning methods for predicting corrosion inhibition efficiency (IE) are limited to specific inhibitor categories with high cost and poor generalization. In this study, a cross-category corrosion inhibitor dataset is constructed and a three-level direct message passing neural network (3 L–DMPNN) model using molecular structure information that integrates atomic-level, chemical bond-level, and molecular-level features to predict the IEs of compounds in a specific environment is established. This work demonstrates that the 3 L–DMPNN model can predict IEs of cross-category corrosion inhibitors from other independent literature and experimental dataset effectively and quickly.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
- …
