10 research outputs found
Laser-induced surface recrystallization of polycrystalline PbI2 thick films for X-ray detector application
No full text
Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss
No full textAbstractNo therapies exist to prevent neuronal deficits in multiple sclerosis (MS), because the molecular mechanism responsible for the progressive neurodegeneration is unknown. We previously showed that axon injury-induced neuronal endoplasmic reticulum (ER) stress plays an important role in retinal ganglion cell (RGC) death and optic nerve degeneration in traumatic and glaucomatous optic neuropathies. Optic neuritis, one of the most common clinical manifestations of MS, is readily modeled by experimental autoimmune encephalomyelitis (EAE) in mouse. Using this in vivo model, we now show that ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2α-CHOP and activation of XBP-1 in RGC specifically, protects RGC somata and axons and preserves visual function. This finding adds to the evidence that ER stress is a general upstream mechanism for neurodegeneration and suggests that targeting ER stress molecules is a promising therapeutic strategy for neuroprotection in MS.</jats:p
A Case Study of Social Learning in ICALL-Based English Writing Course from Learners’ Perspectives
Full text linkAs one of the essential theoretical concepts in sociocultural theory, social learning addresses that any learning is fundamentally a social learning process, which results from the interaction between individuals and their social context. The principal aim of this study is to explore what has come out of the social learning process in a case of a iCALL-based EFL writing course in a university in China. The study investigated 54 learners’ attitudes towards the iCALL-based English writing course and what they really gained from peers’ interaction (reading and commenting on peers’ writings). Data was collected by means of structured and semi-structured questionnaire, open-ended interview, and collection of online-texts; data analysis was done both quantitatively and qualitatively via SPSSAU, coding and content analysis. The results demonstrate that the majority of the students have a positive attitude toward this iCALL-based English writing course, and their gains from the dialogic activity include not only their improvement in language writing ability, but also non-linguistic aspects falling into the following four aspects: cognitive domain, meta-cognitive domain, affective domain, and meaning of life. The researcher concludes that the social learning process in this case was not only a good source for languaging, which leads to the improvement of learners’ language ability in the process of joint construction, but also a good source for affective and social communication within the learning community
Risk of Budd-Chiari syndrome associated with factor V Leiden and G20210A prothrombin mutation: a meta-analysis.
No full textVarious studies have demonstrated that factor V Leiden (FVL) and G20210A prothrombin mutation contribute to the risk of Budd-Chiari syndrome (BCS), while other studies provided conflicting findings. In order to derive more precise estimations of the relationships, a meta-analysis was performed.Eligible articles were identified through search of databases including Pubmed, Chinese Biomedical Database (CBM, Chinese), and Chinese National Knowledge Infrastructure (CNKI, Chinese). Odd ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed- model.Finally, twelve studies were included for FVL and nine studies were included for G20210A prothrombin mutation. With respect to FVL, significantly increased BCS risk was found in the overall population (OR = 6.29, 95%CI = 4.23-9.36). Subgroup analyses suggested that FVL was associated with an increased risk of BCS in the population with high background mutation prevalence (>1% in the normal population). No significant association was found between BCS and G20210A prothrombin mutation (OR = 1.78, 95%CI = 0.77-4.11).The presence of FVL should be evaluated in patients with BCS. Conversely, G20210A prothrombin mutation is not significantly associated with risk of BCS. Large-scale well designed studies are necessary to be conducted to further confirm or refute the observed association
Flow chart of the selection process for including article.
No full text<p>Flow chart of the selection process for including article.</p
Forest plot of the association between BCS and FVL (a), and G20210A prothrombin mutation (b).
No full text<p>Forest plot of the association between BCS and FVL (a), and G20210A prothrombin mutation (b).</p
Begg’s funnel plot: publication bias for the studies on FVL (a), and on G20210A prothrombin mutation (b).
No full text<p>Begg’s funnel plot: publication bias for the studies on FVL (a), and on G20210A prothrombin mutation (b).</p
Sensitivity analysis of the association between BCS and FVL (a), and G20210A prothrombin mutation (b).
No full text<p>Sensitivity analysis of the association between BCS and FVL (a), and G20210A prothrombin mutation (b).</p
