36 research outputs found
Author correction: Micromotor-enabled active drug delivery for in vivo treatment of stomach infection
No full textAbstractMarygorret Obonyo, who provided the H. pylori SS1 strain for this work and participated in the design of H. pylori infection studies, was inadvertently omitted from the author list. This has now been corrected in both the PDF and HTML versions of the Article.</jats:p
Male brushstrokes and female touch: medical writings on childbirth in Imperial China
No full textThis dissertation is a study of Shichan lun (Ten Topics on Birth), a widely disseminated medical treatise produced in the Northern Song dynasty (960-1127), around the early twelfth century. Shichan lun records how childbirth progressed and it also contains detailed descriptions of hand techniques deployed by women practitioners during birth complications. I examine its composition, incorporation into a larger work (in the thirteenth century), and redaction (ca. early to mid-sixteenth century). In Chapter One, I translate and analyze the earliest extant edition of Shichan lun, collected in Chen Ziming's Furen daquan liangfang (All Inclusive Good Prescriptions for Women, pub. 1238). I highlight the use of childbirth pain descriptions as a diagnostic "tool" during delivery and the hand techniques women practitioners used to manage birth complications. In Chapter Two, I provide a composite biography of the author of Shichan lun, Yang Zijian (fl. 1100), and analyze the reasons why a literatus came to write about childbirth in the early twelfth century and his literary network. Chapter Three is devoted to the study of Chen Ziming (fl. 1237-1271), who incorporated Shichan lun into his work. I examine Chen's authorial impulse and evaluate his involvement in re-defining women's medicine. Chapter Four is a study of the changes introduced by Xue Ji (1487-1558), the sixteenth century medical author, to Chen Ziming's work and Shichan lun. My conclusion addresses how Shichan lun, a work of a technical and practical nature, resisted theoretical incorporation, and the problems of using male-authored sources to study women's medicine and women practitioners.Cette thèse de doctorat est une étude biographique du Shichan Lun (Dix discours sur la naissance), un traité médical rédigé dans la dynastie des Song du Nord (960-1127) autour du début du XIIe siècle et largement diffusé jusqu'aujourd'hui. Shichan lun enregistre l'évolution des méthodes d'accouchement et contient également des descriptions détaillées des techniques manuelles déployés par les praticiens femmes pendant les complications de l'accouchement. J'examine la composition de l'oeuvre, l'intégration de l'oeuvre à un ouvrage plus large (au XIIIe siècle) ainsi que sa rédaction (ca. début au milieu du XVIe siècle).Dans le premier chapitre, je traduis et j'analyse la première édition existante du Shichan lun, recueillie dans le Furen daquan Liangfang de Chen Ziming (prescriptions inclusives et bonnes pour les femmes, pub. 1238). Je souligne l'utilisation des descriptions de la douleur de l'accouchement comme un «outil» de diagnostic pendant l'accouchement et les techniques manuelles utilisées par les praticiens femmes pour gérer les complications de l'accouchement. Dans le deuxième chapitre, je fournis une biographie composite de l'auteur du Shichan lun, Yang Zijian, en analysant les raisons pour lesquelles un lettré se mit à écrire au sujet de l'accouchement au début du XIIe siècle ainsi que son réseau littéraire. Le troisième chapitre est consacré à l'étude de Chen Ziming qui a incorporé le Shichan lun dans son oeuvre. J'examine impulsion d'authorial de Chen et j'évalue son implication dans la redéfinition de la médecine des femmes. Le chapitre quatre est une étude au sujet des changements introduits par Xue Ji, auteur médical du XVIe siècle, dans l'oeuvre de Chen Ziming et dans le Shichan Lun. En conclusion, je constate la façon dont le Shichan lun, un oeuvre de caractère technique et pratique, a résisté l'incorporation théorique ainsi que les problèmes de l'utilisation de sources d'auteurs masculins quant à l'étude de la médecine des femmes et des praticiens femmes
Diode-pumped passively Q-switched mode-locking Tm:LLF laser with graphene oxide saturable absorber
No full textPrevalence and Correlates of Psychological Symptoms in Chinese Doctors as Measured with the SCL‐90‐R: A Meta‐Analysis
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An unconventional role of ligand in continuously tuning of metal–metal interfacial strain
No full textWe show that embedding of a surface ligand can dramatically affect the metal–metal interfacial energy, making it possible to create nanostructures in defiance of traditional wisdom. Despite matching Au–Ag lattices, Au–Ag hybrid NPs can be continuously tuned from concentric core–shell, eccentric core–shell, acorn, to dimer structures. This method can be extended to tune even Au–Au and Ag–Ag interfaces
hybrid nanoparticles for the prevention of cartilage degradation
No full textCurrent drug delivery approaches for the treatment of cartilage disorders such as osteoarthritis (OA) remain inadequate to achieve sufficient drug penetration and retention in the dense cartilage matrix. Herein, we synthesize sub-30 nm lipid-polymer hybrid nanoparticles functionalized with collagen-targeting peptides for targeted drug delivery to the cartilage. The nanoparticles consist of a polymeric core for drug encapsulation and a lipid shell modified with a collagen-binding peptide. By combining these design features, the nanoparticles can penetrate deep and accumulate preferentially in the cartilage. Using MK-8722, an activator of 5'-adenosine monophosphate-activated protein kinase (AMPK), as a model drug, the nanoparticles can encapsulate the drug molecules in high capacity and release them in a sustained and controllable manner. When injected into the knee joints of the mice with collagenase-induced OA, the drug-loaded nanoparticles can effectively reduce cartilage damage and alleviate the disease severity. Overall, the ultrasmall targeted nanoparticles represent a promising delivery platform to overcome barriers of dense tissues for the treatment of various indications, including cartilage disorders
Design Strategies for Cellular Nanosponges as Medical Countermeasures
No full textThe interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously. Among various nanomedicine platforms, cell membrane-coated nanoparticles, namely, “cellular nanosponges,” stand out for their broad-spectrum neutralization capability challenging to achieve in traditional countermeasure technologies. Such ability is attributable to their cellular function-based rather than target structure-based working principle. Integrating cellular nanosponges with various synthetic substrates further makes their applications exceptionally versatile and adaptive. This review discusses the latest cellular nanosponge technology focusing on how the structure–function relationship in different designs has led to versatile and potent medical countermeasures. Four design strategies are discussed, including harnessing native cell membrane functions for biological neutralization, functionalizing cell membrane coatings to enhance neutralization capabilities, combining cell membranes and functional cores for multimodal neutralization, and integrating cellular nanosponges with hydrogels for localized applications. Examples in each design strategy are selected, and the discussion is to highlight their structure–function relationships in complex disease settings. The review may inspire additional design strategies for cellular nanosponges and fulfill even broader medical applications
One-step synthesis of composite vesicles: Direct polymerization and in situ over-oxidation of thiophene
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