180 research outputs found
Lithosphere thinning beneath west North China Craton: Evidence from geochemical and Sr-Nd-Hf isotope compositions of Jining basalts
No full textThis study shows lithosphere evolution history in the west North China Craton (NCC) from the early Cretaceous to Quaternary by studying the major element, trace element and Sr-Nd-Hf isotope compositions in Jining basalts of 119.6-108.6. Ma, 23.5-21.9. Ma and 1.3-0.11. Ma.The early Cretaceous basalts (119.6-108.6Ma) display enriched characteristics with high contents of incompatible elements, high 87Sr/86Sri, low εNd(t) and low εHf(t). These basalts resulted from partial melting of ancient metasomatized lithospheric mantle, and we consider the 119.6-108.6Ma magmatism as indicating lithosphere thinning in the west NCC. Although the Pacific slab seen seismically in the mantle transition zone beneath eastern China is no older than 60Ma, there exists convincing evidence for the presence of the Paleo-Pacific slab in the transition-zone in the Mesozoic. Thus we propose that the water released from the transition-zone slab hydrated the overlying lithosphere and further converted the base of the lithosphere into asthenosphere. This is the most likely mechanism responsible for the lithosphere thinning in the west NCC and the petrogenesis of the Jining 119.6-108.6Ma basalts.The Jining 23.5-21.9Ma basalts also have high contents of incompatible elements, but they display high εNd(t), high εHf(t) and variably low 87Sr/86Sri. We propose that these Miocene basalts were derived from the asthenosphere with contributions from ancient metasomatized lithospheric mantle during melt ascent. The Jining Quaternary basalts (1.3-0.11Ma) represent the melt of upwelling asthenosphere with low 87Sr/86Sri, high εNd(t) and high εHf(t). Upwelling and decompression melting of the eastward flowing asthenosphere from beneath western plateaus to beneath eastern hilly plains in the Cenozoic is the most plausible mechanism for the petrogenesis of Jining Cenozoic basalts (both of 23.5-21.9Ma and 1.3-0.11Ma), but the Jining 1.3-0.11Ma basalts must have been produced beneath even thinner lithosphere.Taken together geophysical studies and our petrological and geochemical studies of all these three episodes of the Jining basalts, we propose that the lithosphere in the west NCC has been thinning since the early Cretaceous and the thinning continues to the present
Polymorphism of 5 ' regulatory region of caprine FSHR gene and its association with litter size in Jining Grey goat
No full textSingle nucleotide polymorphisms of the 5' regulatory region of the FSHR gene were detected in 3 goat breeds (Jining Grey, Boer, and Inner Mongolia Cashmere) by the polymerase chain reaction-single-strand conformation polymorphism method, and its effects on litter size in Jining Grey goats were also evaluated. Concerning primer P1, 2 genotypes (AA and BB) were detected in Boer goats, while only the AA genotype was identified in Jining Grey and Inner Mongolia Cashmere goats. Sequencing revealed a T -> A transversion at the 26th position and an A. C transversion at the 61st position of the amplified region in genotype BB in comparison to genotype AA. Regarding primer P2, 3 genotypes (CC, CD, and DD) were identified in the 3 goat breeds mentioned above. Sequencing revealed a T -> A transversion at the 70th position and a G -> C transversion at the 130th position of the amplified region in genotype DD compared with CC. Does with genotype CC had 0.46 (P < 0.05) or 1.03 (P < 0.05) kids more than those with genotype CD or DD, respectively, while does with CD had 0.57 (P < 0.05) kids more than those with DD in Jining Grey goats. These results preliminarily showed that allele C of the FSHR gene was a potential marker for improving litter size in goats.Veterinary SciencesSCI(E)1ARTICLE5497-5033
Traits of the MG reference varieties planted in spring in Heihe, Harbin, Jining and Wuhan in China.
No full textTraits of the MG reference varieties planted in spring in Heihe, Harbin, Jining and Wuhan in China.</p
LA-ICP-MS U-Pb zircon ages of the khondalites from the Wulashan and Jining high-grade terrain in northern margin of the North China Craton: Constraints on sedimentary age of the khondalite
No full textThe Wulashan and Jining Complexes in northern margin of the North China Craton are high grade terrains that are composed predominantly of TTG gneisses, granulites, amphibolites and khondalites. Traditionally, all these rocks were considered as metamorphic supracrustals and their ages were arbitrarily assigned according to their metamorphic grade, i. e. the higher grade rocks were older than those lower grade rocks. Recently, the complex has been divided into metamorphosed plutons and supracrustals, but their ages remain controversial, with most workers believing that the plutons formed in the middle Archean, whereas the khondalites formed in the late Archean. To resolve this important issue, we applied the LA-ICP-MS U-Pb zircon dating technique, combined with CL images of zircons, to determine the ages of detrital and metamorphic zircons in the khondalites from the Wulashan and Jining Complexes. The results show that the metamorphic zircons of the khondalites from the Wulashan and Jining Complexes formed at ∼1.8 Ga, consistent with the metamorphic ages of ∼1.85 Ga obtained using the TIMS method. Detrital zircons in the khondalites from the Hadamengou, Taoerwan and Yaoziwan areas of the Wulashan Complex yielded LA-ICP-MS U-Pb zircon ages ranging from 2.0 to 2.3 Ga, and the detrital zircons in the khondalites from the Huangtuyao area of the Jining Complex yielded the same age range. These ages demonstrate that the protoliths of khondalites from the Wulashan and Jining Complexes formed in the Paleoproterozoic, not in the Archean as previously considered. In addition, a kf-granite sample collected from the Damiao area of the Wulashan Complex yielded a LA-ICP-MS U-Pb zircon age of ∼2.5 Ga, similar to those ages already obtained for the granulites and TTG gneisses in the Wulashan and Jining Complexes. Although these Archean granulites, TTG gneisses and granites are spatially associated with the khondalites, the former are much older in age than the latter, which suggests that the protoliths of the khondalites were not in-situ deposition, but were allochthonous sediments whose interdigitation with the Archean granulites and TTG gneisses formed by the tectonic processes of the Lüliang Movement.link_to_subscribed_fulltex
LA-ICP-MS U-Pb geochronology of detrital zircons from the Jining Complex, North China Craton and its tectonic significance
No full textLA-ICP-MS U-Pb zircon dating and cathodoluminescene (CL) image analysis were carried out to determine the protolith and metamorphic ages of high-grade Al-rich gneisses, named as "khondalites", from the Jining Complex of the North China Craton (NCC). The analytical results of more than 200 detrital zircon grains from the khondalites show three main age populations: 2060 Ma, 1940 Ma and 1890 Ma. These data indicate that the provenance of the Jining khondalites is Paleoproterozoic in age, but not Archean as previously suggested, and the sediments were derived from a provenance different from the Eastern Block and the Yinshan Terrane of the NCC. The nearly concordant youngest age of 1842 ± 16 Ma (207Pb/206Pb age) for the detrital zircons is interpreted as the maximum depositional age of the khondalites. Overgrowth rims of detrital zircons yield an age of 1811 ± 23 Ma, which we interpret as the metamorphic age. The new age data are consistent with the recent three-fold tectonic subdivision of the NCC and support that the Eastern and Western Blocks collided at ∼1.8 Ga to form the coherent NCC. © 2005 Elsevier B.V. All rights reserved.postprin
Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity
No full textQing Zhang,1 Deshuai Liang,2 Chengfang Zhang,3 Ling Ye,4 Ping Sun,4 Hongli Zhu,4 Yongqin Zhao,4 Yuewen Li,4 Yun Guan,4 Haiguo Zhang4 1College of Clinical Medicine, Jining Medical University, Jining, 272013, People’s Republic of China; 2Department of Pharmacy, Jining NO. 1 People’s Hospital, Jining, 272000, People’s Republic of China; 3Department of Clinical Laboratory, Jining NO. 1 People’s Hospital, Jining, 272000, People’s Republic of China; 4Department of Hematology, Jining NO. 1 People’s Hospital, Jining, 272000, People’s Republic of ChinaCorrespondence: Haiguo Zhang; Yun Guan, Jining NO. 1 People’s Hospital, 6 Jiankang Road, Jining Shandong, 272000, People’s Republic of China, Tel/Fax +86-0537 2257626 ; +86-0537 2087093, Email [email protected]; [email protected]: Mitoxantrone (MTX) is largely restricted in clinical usage due to its significant cardiotoxicity. Multiple studies have shown that an imbalance in the gut-heart axis plays an important role in the development of cardiovascular disease (CVD). We aim to explore the possible correlations between gut microbiota (GM) compositions and cardiometabolic (CM) disorder in MTX-triggered cardiotoxicity mice.Methods: MTX cumulative dose of 6 mg/kg was administered to healthy Kunming male mice to trigger cardiotoxicity, with 1 mg/kg twice weekly for a duration of 3 weeks. Plasma CK-MB and LDH levels were determined, and the heart tissue histopathology was assessed, followed by utilizing an integrated liquid chromatography-mass spectrometry (LC-MS)-based heart metabolomics study alongside the 16S ribosomal RNA (rRNA) sequencing method to assess MTX impact on GM and CM profiles in mice, establishing associations between GM and CM profiles through the Pearson correlation coefficient calculation.Results: MTX caused CK-MB and LDH level elevations and cardiotoxicity in our mouse model. MTX primarily affected the processes of protein digestion and absorption, mineral absorption, membrane transport, production of aminoacyl-transfer RNA (tRNA), metabolism of nucleotides, lipids, and amino acids, as well as autophagy. Additionally, MTX increased Romboutsia, Enterococcus, and Turicibacter abundances and lowered norank_f__Muribaculaceae, Alistipes, Odoribacter, norank_f__Lachnospiraceae, norank_f__Ruminococcaceae, norank_f__Oscillospiraceae, unclassified_f__Ruminococcaceae, NK4A214_group, Colidextribacter, norank_f__norank_o__Clostridia_vadinBB60_group, Rikenella, and Anaerotruncus abundances. The correlation analyses showcased variations in the abundance of diverse flora, such as Romboutsia, Enterococcus, Turicibacter, and norank_f__Muribaculaceae, which were related to MTX-induced cardiac injury.Conclusion: Our study supports the claim that MTX provokes cardiotoxicity by modifying CM and GM profiles. Our results offer new possibilities for controlling MTX-triggered cardiotoxicity.Keywords: 16S ribosomal RNA, liquid chromatography-mass spectrometry, mitoxantrone, cardiotoxicit
The Mediating Role of Avoidant Personality Disorder Features in the Relationship Between Stressful Life Events and Depression Among First-Year University Students
No full textHuihui Zhou,1,* Sifang Niu,1,2,* Yangziye Guo,1,3 Yan Qin,1,3 Hao Sun,4 Fuqin Mu,5 Ximing Duan,5 Yi Zheng,5 Ying Zhang,6 Yan Liu,1 Ning Liu7 1School of Public Health, Jining Medical University, Jining, 270213, People’s Republic of China; 2School of Public Health and Management, Binzhou Medical University, Yantai, 264003, People’s Republic of China; 3School of Public Health, Shandong First Medical University, Jinan, 250117, People’s Republic of China; 4School of Clinical Medicine, Jining Medical University, Jining, 270213, People’s Republic of China; 5School of Mental Health, Jining Medical University, Jining, 272013, People’s Republic of China; 6School of Public Health, University of Sydney, Sydney, NSW, 2006, Australia; 7School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Liu, School of Public Health, Jining Medical University, Jining, 272065, People’s Republic of China, Email [email protected] Ning Liu, Department of Graduate, Jining Medical University, Jining, 272065, People’s Republic of China, Email [email protected]: Stressful life events are risk factors of depression. To explore whether the avoidant personality disorder (AVPD) features play a mediating role between stressful life events (SLEs) and depression among Chinese first-year university students.Methods: The cross-sectional study was conducted from April to October 2018. The participants were the freshmen selected from Jining Medical University and Weifang Medical University (n=7390) in Shandong Province in China. Depression was assessed by the Beck Depression Inventory-II, AVPD were measured by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM 5). The data were processed and analyzed by SPSS24.0 software, Pearson correlation analysis and PROCESS3.3 program intermediary analysis. The method of Bootstrap was adopted to determine whether the AVPD features act as mediating factors in the association between the NLEs and depression.Results: A total of 34.68% of the participants reported one to three AVPD features, and 18.15% reported four to seven AVPD features. AVPD features (r=0.384, P< 0.05) and the SLEs (r=0.309, P< 0.05) were positively related to the risk of depression, respectively. AVPD features play a partial mediating effect on the relationship between SLEs and depression (the effect value is 0.133, P < 0.01; 32.28% of the total effect).Limitation: There might be recall bias in this cross-sectional study.Conclusion: AVPD features are prevalent among Chinese university students. AVPD features displayed the mediation effect on depression related to stressful life events. Psychological interventions for depression in college students should focus not only on stress but on individual personality traits and cognitive mode. Care-givers, teachers, and health professionals should pay more attention to the early identification of the AVPD features among university students.Keywords: stressful life events, depression, avoidant personality disorder, mediato
The Ve-R7 duration ranges of the MG reference varieties from the US in Heihe, Harbin, Jining and Wuhan in China.
No full textThe Ve-R7 duration ranges of the MG reference varieties from the US in Heihe, Harbin, Jining and Wuhan in China.</p
Fundamental study of printing accuracy in Fused Deposition Modelling for bioinspired micro-structured surfaces
No full textThe use of micro- and nanostructured surfaces has been explored as a new strategy to
enable special surface functions in a variety of areas such as wettability control, anti-biofouling, optical properties, tribology studies, and adhesion resistance. Many
manufacturing methods can be applied for producing structured surfaces, including
lithographic techniques, femtosecond laser machining or single point diamond turning.
However, the cost has often been a critical barrier for the fabrication of functional surfaces
on a mass scale.
3D printing techniques have recently emerged as a viable technology due to low material
consumption, and high energy efficiency. Among these, Fused Deposition Modelling
(FDM) provides a simpler manufacturing process and a more cost-effective method than
other prominent 3D printing techniques. Despite the constant improvements in the
resolution of this method, FDM still has the disadvantage of excessive extrudate
expansion, limiting its application in precision manufacturing of functional structured
surfaces.
This work aims to develop a novel manufacturing method based on FDM for the
fabrication of functional microstructures on thermoplastic polymers in a more cost-effective manner with high throughput on very large scales, which potentially could be
applied in the fabrication of bioinspired functional surfaces. For this purpose, the study
first assesses the manufacturing accuracy of FDM by measuring the die swell effect of
extrudate PLA filaments under varied working conditions in terms of extrusion
temperatures (170 ⁰C – 210 ⁰C), printing speeds (10 mm/s – 80 mm/s), layer heights (0.10
mm – 0.40 mm) and nozzle sizes (0.20 mm – 0.40 mm). Different cooling methods are
also applied in the printing process to suppress the die swell effect and therefore improve
the manufacturing accuracy.
By revealing the limitations of conventional theoretical models for predicting filament
die swell in FDM process, a numerical model based on the level-set technique is
developed to predict FDM extrudate die swell under different extruding conditions. This
simulation method is also applied for studying the expansion of patterned structures
during the extrusion process. The functions of structured surfaces are demonstrated by
enhancing the wettability of a variety of polymers, including polyvinyl chloride (PVC),
polyethylene 1000 (PE 1000), polypropylene copolymer (PP), and polytetrafluoroethylene (PFTE). It has been found that materials initially exhibiting
common wettability properties (θ ≈ 90°) can exhibit “superhydrophobic” behaviour (θ ˃
150°
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway
No full textYingxu Shi,1 Yu Tang,2 Zhiwei Sun,3 Ping Sui,4 Yiming Shao,4 Zhonghao Wang,4 Jian Zhang,1 Ming Gao1 1Department of Trauma Orthopedics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272007, People’s Republic of China; 2Pharmaceutical Department, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272007, People’s Republic of China; 3Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; 4Department of Clinical Medicine, Jining Medical University, Jining, Shandong, 272067, People’s Republic of ChinaCorrespondence: Ming Gao, Department of Trauma Orthopedics, Affiliated Hospital of Jining Medical University, No. 129 hehua Road, Jining, Shandong, 272007, People’s Republic of China, Tel + 86-0537-0298202, Email [email protected]: Osteosarcoma (OS) is the most common malignant tumor associated with poor patient outcomes and a limited availability of therapeutic agents. Scutellarein (SCU) is a monomeric flavone bioactive compound with potent anti-cancer activity. However, the effects and mechanisms of SCU on the growth of OS remain unknown.Methods: The Cell Counting Kit-8, colony formation assay and 5-ethynyl-2′-deoxyuridine (EdU) incorporation assays were used to analyze cell proliferation ability in vitro. TLR4/TRAF6/NF-κB signaling transduction was investigated by RNA sequencing analysis, quantitative real-time polymerase chain reaction, Western blotting, NF-κB luciferase reporter assay, immunofluorescent staining, and immunoprecipitation. Molecular docking and cellular thermal shift assay were employed to confirm the binding interaction between SCU and TLR4. The effects of SCU and TLR4 overexpression on OS growth were analyzed using a xenograft tumor model and immunohistochemical staining.Results: SCU was found to significantly inhibit OS cell proliferation, and RNA sequencing analysis suggested that the NF-κB pathway is closely associated with this process. Further studies revealed that SCU inhibited the canonical NF-κB pathway through its binding with TLR4, which disrupted the interaction of TLR4 and TRAF6. Moreover, SCU also repressed NF-κB signal transduction by inhibiting TLR4 expression. Furthermore, SCU was revealed to suppress OS cell proliferation by targeting TLR4 in vitro and in vivo.Conclusion: SCU exhibited a dual impact by inhibiting TLR4 expression and disrupting TLR4–TRAF6 interaction, resulting in NF-κB inactivation, thereby blocking OS growth. Keywords: scutellarein, osteosarcoma, TLR4, NF-κB pathway, molecular modelin
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