10,924 research outputs found
Supplemental Material, jm.18.0270-File003 - Branding Cultural Products in International Markets: A Study of Hollywood Movies in China
No full textSupplemental Material, jm.18.0270-File003 for Branding Cultural Products in International Markets: A Study of Hollywood Movies in China by Weihe Gao, Li Ji, Yong Liu and Qi Sun in Journal of Marketing</p
In vivo excision and amplification of large human genomic segments using the Cre/loxP-and large T antigen/SV40 ori-mediated machinery
No full textIn vivo excision and amplification of pre-determined large genomic segments, directly from the genome of a natural host, can be a powerful tool for obtaining the genomic sequences with minimum rearrangements. In this study, an in vivo excision and amplification system in human BJAB cells was devised by combining the Cre/loxP system of bacteriophage PI and the large T antigen/SV40 ori system of Simian virus 40. Two loxP sequences, each of which serves as a recognition site for recombinase Cre, were integrated unidirectionally into 5'- and 3'-untranslated regions (UTRs) of the human iNOS. An SV40 ori sequence, which serves as a conditional replication system, was inserted between the loxP sites. Trans-acting genes cre and large T antigen, which were under the control of a tetracycline responsive promoter, were also inserted into the 5'- and 3'-UTRs of the iNOS, respectively, by homologous recombination. Upon induction by doxycycline, the 45-kb iNOS genomic fragment of human chromosome 17 flanked by two loxP sites was excised and amplified up to about 45 copies per cell. Our method is very useful for obtaining large genomic fragments in quantities directly from human cells without using foreign hosts. Therefore, our approach can be used effectively for gap sequencing of a genome, gene therapy, and functional analysis of unknown genes in human cells. (C) 2004 Elsevier B.V. All rights reserved
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
A multifaceted perspective on skin cancer prevention
No full textSolar ultraviolet radiation has been acknowledged as the main culprit for the three major
types of skin cancer which are among the most numerous (basal cell carcinoma [BCC],
squamous cell carcinoma [SCC]) and most dangerous (cutaneous malignant melanoma)
malignancies in Caucasian populations.
The present thesis comprises six individual projects providing a multifaceted perspective on
the prevention of these tumours.
Project I evaluated a school-based sun safety education programme developed by the Swiss
Cancer Leagues. Primary school students in the Canton of Zurich (North-Eastern Switzerland)
were asked to answer a questionnaire regarding their sun-related knowledge, behaviour,
and sunburn experience shortly before and one year after the intervention (repeated cross-
sectional assessment). Based on the data from more than 3000 students, the sun safety
education programme was effective in sustainably improving children’s sun-related
knowledge and possibly to some extent in decreasing sunburn rates, but had no obvious
impact on the examined sun protective behaviours (use of sunscreen, seeking shade).
Project II represents a systematic review of cross-sectional and interventional studies on
sun-related knowledge, attitudes, and protective behaviours of outdoor workers. The 52
relevant publications identified through an electronic search of medical literature databases
(PubMed, Embase, PsycINFO) and an extensive hand search suggested that outdoor workers’
sun protective behaviours are largely inadequate and sunburn rates are high (50-80% per
season). However, there is evidence that sun safety education in outdoor occupational
settings is effective in increasing workers’ protective behaviours and presumably also in
reducing sunburn incidence.
Project III investigated sun protective behaviour and sunburn experience of vacationers
spending holidays in the tropics or subtropics. The 1165 standardised face-to-face interviews
conducted among air passengers waiting in the departure or baggage claim area at the
Airport Basel-Mulhouse (Switzerland/France) and among vacationers waiting for pre-travel
health advice at the Travel Clinic of the Swiss Tropical and Public Health Institute Basel
(Switzerland) revealed that almost all respondents used sunscreen at the holiday
destination. Nevertheless, wearing a sunhat and protective clothing as well as seeking shade
were clearly less common sun protection methods. The assessed sunburn rate among the
324 interviewed returning air passengers was alarmingly high, with 44% having suffered
from sunburn during their holiday stay.
Project IV comprehensively analysed the content and quality of 2103 print media articles
pertaining to skin cancer prevention and related topics (solaria, vitamin D) published in
Germany and Switzerland over a one-year period (2012-2013). Whereas skin cancer
secondary prevention received little press attention, primary prevention was a frequently
covered media topic. However, the delivered information was generally rather superficial. By
far the most common and often sole sun protection recommendation made was the use of
sunscreen. In total, 27% of all analysed articles contained misleading or erroneous
statements which were mostly related to the use of sunscreen and vitamin D issues.
Projects V and VI are based on data derived from the Clinical Practice Research Datalink, a
large, well-validated primary care database established in the United Kingdom (UK).
Project V estimated BCC incidence in the UK and characterised affected patients regarding
lifestyle factors and comorbidities. The calculated age-standardised BCC incidence in adults
rose from 119 to 165 per 100 000 person-years between the years 2000 and 2011. According
to the matched case-control analysis including 57 121 BCC cases and 57 121 BCC-free
controls, BCC risk was slightly increased in alcohol drinkers, but reduced in smokers and in
individuals with a body mass index outside the normal range. BCC was associated with
various comorbidities related to iatrogenic or non-iatrogenic immunosuppression.
Project VI explored whether patients regularly exposed to systemic nonsteroidal anti-
inflammatory drugs (NSAIDs) are at a reduced risk of nonmelanoma skin cancer (NMSC). The
matched case-control analysis comprised 65 398 BCC cases, 65 398 BCC-free controls, 7864
SCC cases, and 31 456 SCC-free controls. Overall, NSAID use was not negatively associated
with BCC, but when looking exclusively at users of single NSAID substances there was a
suggestion of a reduced BCC risk in regular users of aspirin and ibuprofen. SCC risk was
slightly decreased in regular users of any NSAIDs, with the strongest risk reduction observed
in current users of coxibs. These findings provide evidence that patients predisposed to
NMSC may benefit from chemoprevention with NSAIDs
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
Translation and interpretation: Translation redundancy reconsidered
No full textInterpretation is an integral part of the process of translating. This article raises the question of whether interpretation fo a literary work by a translator should be guided by extratextual factors or not. The discussion is illustrated with examples taken from David Hawkes' translation of a Chinese classic, A Dream of Red Mansions. As the work of a scholar-translator, Hawkes' version is richly supplemented with disclosures concerning the characters and explanations of the cultural environment embodied in the novel. In many cases, however, this translation procedure is redundant and explanatory, enlightening the readers but at the same time robbing them of the pleasure of literary interpretation and cultural exploration. By means of this illustration of translation redundancy, the author points out that there is difference between a scholar who helps the interpretation fo a work and a translator who presents a work close to its original version. It is particularly important to pay attention tot his difference in literary translations in a cross-cultural situation involving two enormously different cultures.Language & LinguisticsA&HCI0ARTICLE1,SI115-12
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
No full text26.03.14 KB. Ok to accepted version to spiral, 6 months embargo expired
INTERNATIONAL FINANCIAL REPORTING STANDARDS (IFRS), BAIK BAGI USAHA MIKRO KECIL MENENGAH? (Studi Kasus: UMKM JM KERIPIK)
No full textABSTRAKUndang-undang nomor 20 tahun 2008 tentang Usaha Makro Kecil Menengah (UMKM), usaha kecil adalah usaha ekonomi produktif yang berdiri sendiri, yang dilakukan oleh orang perseorangan atau badan usaha yang bukan merupakan anak perusahaan atau bukan cabang perusahaan yang memiliki, dikuasai atau menjadi bagian baik langsung maupun tidak langsung dari usaha menengah atau usaha besar yang memenuhi kriteria. JM Keripik merupakan salah salah UMKM yang bergelut dibidang produksi dan penjualan. IFRS merupakan seperangkat standard yang dikeluarkan oleh Dewan Standard Akuntansi Internasional (IASB). IFRS berguna untuk menyusun laporan keuangan yang dapat diterima di dunia Global.Penulistertarik untukmengetahuipencatatankeuanganJM Keripik dan apakah perlu merekomendasikan IFRS pada UMKM JM Keripik. Metode penelitian yang digunakaan penulis adalah kualitatif yaitu observasi dan wawancara. Dari hasil penelitian banyak terdapat pencatatan-pencatatan yang kurang terperinci, UMKM JM Keripik hanya memilki empat macam pencatatan yaitu pencatatan mengenai: 1.Stock barang, 2.Supliyer, 3.Costumer dan 4.Stock toko, pencatatan ini hanya dapat dimengerti oleh pemilik JM Keripik. Sebaiknya pemilik UMKM JM Keripik mengganti laporan keuangan yang sederhana ke laporan keuangan yang semestinya dan yang berbasis IFRS karena IFRS membawa dampak positif bagi UMKM dan merupakan standar akuntansi keuangan yang digunakan dunia global. Kata Kunci : UMKM, IFRS, JM Keripik ABSTRACT Act number 20 of 2008 concerning the Macro Small and Medium Enterprises, small businesses are productive economic activities that stand alone, carried out by an individual or business entity that is not a subsidiary or not a branch of the company that owns, controlled or become part either directly or indirectly from medium or large businesses that meet the criteria. JM Keripik which deals in the field of production and sales. IFRS is a set of standards issued by the International Accounting Standards Board (IASB). IFRS is useful for preparing financial statements that is acceptable in the global world. Authors interested in knowing the financial records of JM Keripik and whether to recommend IFRS on JM Keripik. The research method is qualitative author of observation and interviews. From the research there are many registries are less detailed, JM Keripik has only four kinds of recording is recording about: 1.Stock goods, 2.Supliyer, 3.Costumer and 4.Stock shop, registration can only be understood by the owner of JM Keripik. JM Keripik owners should replace the simple financial reports to the appropriate financial statements and IFRS-based IFRS for Macro Small and Medium Enterprises had a positive impact and a financial accounting standards global world. Keywords : UMKM, IFRS, JM Keripi
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