6,617 research outputs found
Anxiety and Sun Exposure as Triggers for Herpes Labialis: A Case Report and Review of Literature
Full text linkNadia Tiara Putri,1,* Dhini Karina Octaviani,1,* Dewi Zakiawati2,* 1Oral Medicine Specialist Program, Faculty of Dentistry Universitas Padjadjaran, Bandung, Indonesia; 2Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia*These authors contributed equally to this workCorrespondence: Nadia Tiara Putri, Oral Medicine Specialist Program, Faculty of Dentistry Universitas Padjadjaran, Sekeloa Selatan Street No. 1, Bandung, 40132, Indonesia, Tel +62 81296818202, Fax +62 22 7794121, Email [email protected]: Herpes labialis (HL) is a prevalent viral infection caused by herpes simplex virus type 1 (HSV-1), affecting a significant portion of the global population. The reactivation of HSV-1 leading to HL can be triggered by various factors, including psychosocial factors (depression, stress, and anxiety), exposure to ultraviolet light, a febrile environment, and specific dietary inadequacy.Purpose: This case report explores the association between HL, psychological conditions, and sun exposure.Case Report: A 20-year-old male patient came with a chief complaint of swollen lips with tiny pimples for two days, accompanied by malaise. The patient was working as a florist in a sun-exposed area and experiencing stress due to financial difficulties. Extraorally, multiple vesicles were found on the left side of the upper lip, surrounded by erythema, and painless. Laboratory examinations showed a reactive HSV-1 IgG. The depression, anxiety, and stress scale-21 (DASS-21) questionnaire showed an extremely severe level of anxiety.Case Management: The patient was given systemic and topical acyclovir, multivitamins, hyaluronic acid mouthwash, and petroleum jelly. In addition, the patient was advised to reduce the frequency of sun exposure, apply sunscreen, and seek professional help to manage the anxiety. A review of eight case reports related to HL from 1994– 2024 has been reported in this literature and emphasizes the connection of HL with psychological factors and sun exposure.Conclusion: This case underscores the potential link between anxiety, sun exposure, and the onset of HL. Understanding these associations is crucial for effective management and prevention strategies.Keywords: anxiety, DASS-21, herpes labialis, HSV-1, oral diseases, sun exposur
Performances of the HL (Hyperloop) transport system
No full textThis paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental. The operational performance include capacity and quality of service provided to the system’s users-passengers with attributes such as door-to-door travel time consisting of the access and egress time, schedule delay, in-vehicle time, and interchange time. The economic performances embrace the costs and revenues of operating the system. The costs include that for infrastructure, vehicles, traffic management facilities and equipment, and employees. The revenues embrace earnings from pricing users/passengers. The environmental performances include energy consumption and related emissions of GHGs (Green House Gases), and land use. The social performances are considered to be noise and safety. The analytical models of indicators of these performances are developed and applied to the scenario of operating the HL system on the short- to medium-haul travel distances/routes. These are then compared to the corresponding performances of the HSR and APT. This comparison has shown that the HL system may possess some advantages but also disadvantages regarding particular performances.Transport and PlanningOLD Urban and Regional Developmen
Where are Mifrenz?
Full text linkThis paper describes the further development of an email
application for children, called Mifrenz, in particular the
implementation of the ability to use the application from
more than one physical location. During evaluation of the
previous version of the software, it was discovered that
many children wish to access their email from multiple
physical locations. From this problem the following
objectives for this work were identified: 1) Provide access
to sent and received email from multiple locations, 2)
Provide access to persistent data (contacts and jokes) and
3) Keep the development time to a minimum. During the
design stage the use of the IMAP technology was
identified as the only practical solution for sharing
messages. The design stage also identified IMAP and
Google Docs as two methods for solving the storage of
persistent data problem. Although both of these designs
were shown to work during the development stage, IMAP
was eventually selected as the most appropriate
technology for storing persistent data. The Design
Science Research Process (Peffers, 2006) is used as a
framework in describing this work. The steps of this
process framework are: 1) Problem identification and
motivation, 2) Objectives of a solution, 3) Design and
development, 4) Demonstration, 5) Evaluation and 6)
Communication
Analysis and modelling of performances of the HL (Hyperloop) transport system
No full textIntroduction: Hyperloop (HL) is presented as an efficient alternative of HSR (High Speed Rail) and APT (Air Passenger Transport) systems for long-distance passenger transport. This paper explores the performances of HL and compares these performances to HSR and APT. Methods: The following performances of the HL system are analytically modeled and compared to HSR and APT: (i) operational performance; (ii) financial performance; (iii) social/environmental performance. Results: The main operational result is that the capacity of HL is low which implies a low utilization of the infrastructure. Because the infrastructure costs dominate the total costs, the costs per passenger km are high compared to those for HSR and APT. The HL performs very well regarding the social/environmental aspects because of low energy use, no GHG emissions and hardly any noise. The safety performance needs further consideration. Conclusions: The HL system is promising for relieving the environmental pressure of long-distance travelling, but has disadvantages regarding the operational and financial performances.Transport and PlanningOLD Urban and Regional Developmen
Inhibitory effects of natural plant extracts on ICAM-1/LFA-1 mediated adhesion of HL-60 cells
No full textAtherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries. Monocytes/macrophages are involved in many aspects of the development of atherosclerotic plaques. It is known that the intercellular adhesion molecule-1 (ICAM-1) expressed preferentially on endothelial cells of atherosclerotic plaque, promotes local adhesion and transendothelial migration of monocytes, neutrophils, and lymphocytes. Using the human promyelocytic leukemia HL-60 cell line, we investigated the inhibitory effects of methanol extracts of 175 natural plants on ICAM-1/LFA-1 mediated cell adhesion. Eight kinds of methanol extracts of tested plants inhibited PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity at the concentration of 6.25 μg/ml. They were divided two fractions of CHCl3 and H2O to use solvent partition. Among them, CHCl3 extracts (1.0 μg/ml) of Saururus chinensis and Chloranthus japonicus significantly inhibited aggregation of HL-60 cells without cytotoxicity, respectively.open
Sun smart plants : leaf to leaf signaling in response to high light stress
Full text linkAt high intensities the sun has the potential to cause extensive photo-oxidative damage to plants. From dawn till sunset plants are subjected to varying light intensities across their leaves due to the angle of the sun and shade from clouds, leaves, neighbouring plants and various obstacles. Leaves under high light stress are able to communicate to the rest of the plant to acclimate against the potential threat of oxidative damage caused by the sun's rays: a system known as high light systemic acquired acclimation (HL SAA). This study explores the specific nature of HL SAA, synergistic interactions with other environmental stresses, and the long term adaptation and acclimation response to HL SAA. This necessitated the development of novel experimental systems to investigate the initiation, perception and response to HL SAA. The systems were used to investigate the HL SAA response by monitoring the induction of mRNA in distal leaves not exposed to the HL stress. Acclimation to HL is induced within minutes and the response is proportionally dependent on the quality and quantity of light. Specialized HL SAA treatments in conjunction with variations in temperature and humidity reveal HL SAA is influenced by fluctuations in humidity levels; however small changes in temperature did not affect HL SAA. Localization of hydrogen peroxide (H{u2082}O{u2082}), following HL treatments, and chemical infiltration designed to mimic HL SAA using H{u2082}O{u2082} and singlet oxygen ({u00B9}O{u2082}), show that reactive oxygen species lack the ability to induce strong HL SAA-like responses. H{u2082}O{u2082} elicited responses which were analogous to mechanical stress responses, whereas {u00B9}O{u2082} induced greater induction of HL SAA reporter gene, ZAT10, indicating its potential role in HL SAA. HL SAA induced changes in auxin accumulation and auxin-responsive genes. Long term acclimation studies also confirmed the ability of mature leaves to influence the development and acclimation of emerging and young leaves to HL stress
New Analogues of (E)-beta-Farnesene with Insecticidal Activity and Binding Affinity to Aphid Odorant-Binding Proteins
No full textThe p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion.
No full textRecent advance progress of HL-3 experiments
No full textSince the first plasma realized in 2020, a series of key systems on HL-3 (known as HL-2M before) tokamak have been equipped/upgraded, including in-vessel components (the first wall, lower divertor, and toroidal cryogenic/water-cooling/baking/glow discharge systems, etc.), auxiliary heating system of 11 MW, and 28 diagnostic systems (to measure the plasma density electron temperature, radiation, magnetic field, etc.). Magnet field systems were commissioned firstly for divertor plasma discharges. During the 2nd experimental campaign of HL-3 tokamak, several great progresses have been achieved. Firstly, the successful operation with plasma current larger than 1 MA was achieved under a divertor configuration. Secondly, the advanced divertor concept with two distinct snowflake configurations was realized. It is found that the distribution of ion saturation current and heat flux on bottom plate becomes wide due to magnetic surface expansion, demonstrating the advantage of such configuration in the heat flux mitigation. In addition, using the combination of NBI, ECRH and LHCD, the standard sawtoothing high confinement mode of megampere plasma was firstly accessed on the HL-3. The successful commissioning of HL-3 is beneficial for the initial operation of ITER
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