54 research outputs found
Nietzsche’s Philosophy of Life
No full textThis dissertation is an exploration of Nietzsche’s perspectives on life and aims to demonstrate how his thinking forms the basis for an affirmative understanding of human flourishing. This exploration will also show how and why Nietzsche’s philosophy effectively responds to nihilism. To achieve this objective, three distinct dimensions of Nietzsche’s idea of life — morality, art, and play — have been selected, which correspond to the figures of the “camel,” the “lion,” and the “child,” as presented in Nietzsche’s Thus Spoke Zarathustra. It is argued that these three figures, and consequently the associated concepts, constitute a comprehensive and cohesive framework for interpreting Nietzsche’s philosophy of life. Although these three states do not coexist or operate in parallel within Nietzsche’s philosophy, a discernible continuity between them and throughout Nietzsche’s writings can be identified. In this sense, the overarching aim of this thesis is articulated through the following interrogations: In what manner does Nietzsche’s philosophy seek to overcome and surmount nihilism? How does Nietzsche’s philosophy “define” and engage with the “will to power”
Choosing Healthy Food in Sydney's Inner City Neighborhoods
No full textAbstractDiet-related chronic diseases are a major health problem faced by developed and developing countries. Although individuals’ dietary patterns are often associated with varied psychological and socioeconomic factors, built environment factors can be important determinants of food choices. Whilst there is some evidence to suggest a link between access to food and food consumption, it remains unclear how a wider range of built environment factors influence residents’ food choices. A deeper understanding of these relationships could reveal under-researched aspects of a healthy built environment. This paper explores how residents in inner Sydney neighborhoods access food and investigates how characteristics of the built environment influence their food choices. Eighteen participants, representing a range of ethnic backgrounds and levels of income, were selected for in-depth interviews. Several urban barriers to healthy food consumption were identified through analysis. Distance, land use and urban form, in particular, shape the food choices of individuals in different ways. These findings have implications for urban planning and policy making for healthy cities
A new artificial photosynthetic system coupling photovoltaic electrocatalysis with solar heating catalysis
No full textIn this work, we present a novel artificial photosynthetic paradigm with square meter (m2) level scalable production by integrating photovoltaic electrolytic water splitting device and solar heating CO2 hydrogenation device, successfully achieving the synergy of 1 sun driven 19.4% solar to chemical energy efficiency (STC) for CO production (2.7 times higher than that of large-sized artificial photosynthetic systems) with a low cost (equivalent to 1/7 of reported artificial photosynthetic systems). Furthermore, the outdoor artificial photosynthetic demonstration with 1.268 m2 of scale exhibits the CO generation amount of 258.4 L per day, the STC of ~15.5% for CO production in winter, which could recover the cost within 833 sunny days of operation by selling CO
A new artificial photosynthetic system coupling photovoltaic electrocatalysis with solar heating catalysis
No full textIn this work, we present a novel artificial photosynthetic paradigm with square meter (m2) level scalable production by integrating photovoltaic electrolytic water splitting device and solar heating CO2 hydrogenation device, successfully achieving the synergy of 1 sun driven 19.4% solar to chemical energy efficiency (STC) for CO production (2.7 times higher than that of large-sized artificial photosynthetic systems) with a low cost (equivalent to 1/7 of reported artificial photosynthetic systems). Furthermore, the outdoor artificial photosynthetic demonstration with 1.268 m2 of scale exhibits the CO generation amount of 258.4 L per day, the STC of ~15.5% for CO production in winter, which could recover the cost within 833 sunny days of operation by selling CO
The impact of prophylactic dexamethasone on postoperative sore throat: an updated systematic review and meta-analysis
No full textYaofei Jiang,1–4,* Ruoxi Chen,2,* Suming Xu,2,* Jiaxi Li,2,* Fanqi Yu,2 Lingdong Kong,2 Yuhan Sun,2 Yuan Ye,2 Yimin Li,2 Mengqi Yu,2 Jiaming Wu1 1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, China; 2Department of General Surgery, The Second Affiliated Hospital, Nanchang University, Nanchang, China; 3Hubei Cancer Clinical Study Centre, 4Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan, China *These authors contributed equally to this work Background/Aims: An updated systematic review and meta-analysis was conducted to assess the effect of prophylactic dexamethasone for tracheal intubation of general anesthesia on ­postoperative sore throat (POST). Methods: Comprehensive literature search of databases for randomized controlled trials (RCTs), including Embase, PubMed, and Cochrane Library, which evaluate the effect of prophylactic dexamethasone on POST was conducted. RevMan 5.0 and STATA 12.0 software were used to perform meta-analyses. Results: Fourteen RCTs totaling 1,837 patients were included for analysis. Compared with placebo, a significant reduction in the incidence of POST (OR 0.44, 95% CI 0.33–0.58, P<0.00001), hoarseness (OR 0.42, 95% CI 0.31–0.58, P<0.00001), and postoperative nausea and vomiting (PONV) (OR 0.06, 95% CI 0.03–0.14, P<0.00001) and a comparable incidence of cough (OR 0.59, 95% CI 0.19–1.89, P=0.38) was described in patients receiving dexamethasone, with or without concomitant drugs. Dexamethasone ≥0.2 mg/kg had a statistically greater impact on reducing the incidence of POST than dexamethasone 0.1–0.2 mg/kg, while dexamethasone ≤0.1 mg/kg did not. Dexamethasone was as effective as other drugs such as ondansetron, magnesium sulfate, ketamine gargle, betamethasone gel, and ketorolac for reducing POST (OR 0.70, 95% CI 0.46–1.07, P=0.10). Dexamethasone plus a different drug was more effective than dexamethasone alone for reducing the incidence of POST at 24 hours (OR 0.40, 95% CI 0.21–0.77, P=0.006). Compared with controls, a statistically higher blood glucose level was the only adverse event during the immediate postoperative period in patients receiving dexamethasone. Conclusions: Intravenous dexamethasone ≥0.2 mg/kg within 30 minutes before or after induction of general anesthesia should be recommended as grade 1A evidence with safety and efficacy in reducing the incidence of POST, hoarseness, and PONV in patients without pregnancy, diabetes mellitus, or contraindications for corticosteroids. Keywords: systematic review, meta-analysis, corticosteroids, dexamethasone, postoperative sore throa
A Sub-Synchronous Oscillation Suppression Strategy for Doubly Fed Wind Power Generation System
No full textDuring the power transmission of doubly-fed induction generator (DFIG), due to the influence of series compensating capacitance and long-distance transmission, DFIG is prone to sub-synchronous oscillation, which damages the stability of the system. By establishing the mathematical model of DFIG system, the cause of sub-synchronous oscillation and its influence on the control strategy of DFIG system are discussed. In order to solve the problem of performance degradation of traditional phase-locked loop (PLL) under sub-synchronous oscillation, an improved PLL is proposed to replace the traditional PLL. Aiming at the problem that the control of rotor side converter(RSC) and grid side converter(GSC) in doubly-fed wind power generation system under sub-synchronous oscillation is disturbed by harmonic signals, a control method of adding a quasi resonant controller in the control link of RSC and GSC to suppress sub-synchronous oscillation is proposed, and the feasibility of the method is verified by simulation and experiment. Finally, based on the research process of RSC direct resonance control, the sub-synchronous oscillation suppression strategy based on harmonic current extraction is proposed for the frequency adaptability of the quasi resonant controller. The actual performance of the sub-synchronous oscillation suppression strategy is verified through simulation and experiment. The experimental results show that the strategy is effective
IL-33 promotes double negative T cell survival via the NF-κB pathway
No full textAbstract IL-33, which is a crucial modulator of adaptive immune responses far beyond type 2 response, can enhance the function of several T cell subsets and maintain the immune homeostasis. However, the contribution of IL-33 to double negative T (DNT) cell remains unappreciated. Here, we demonstrated that the IL-33 receptor ST2 was expressed on DNT cells, and that IL-33 stimulation increased DNT cells proliferation and survival in vivo and in vitro. Transcriptome sequencing analysis also demonstrated that IL-33 enhanced the biological function of DNT cells, especially effects on proliferation and survival. IL-33 promoted DNT cells survival by regulating Bcl-2, Bcl-xl and Survivin expression. IL-33-TRAF4/6-NF-κB axis activation promoted the transmission of essential division and survival signals in DNT cells. However, IL-33 failed to enhance the expression of immunoregulatory molecules in DNT cells. DNT cells therapy combined with IL-33 inhibited T cells survival and further ameliorated ConA-induced liver injury, which mainly depended on the proliferative effect of IL-33 on DNT cells in vivo. Finally, we stimulated human DNT cells with IL-33, and similar results were observed. In conclusion, we revealed a cell intrinsic role of IL-33 in the regulation of DNT cells, thereby identifying a previously unappreciated pathway supporting the expansion of DNT cells in the immune environment
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